Studies referencing Hydrogen Dosage

Special Note 1: Only human studies showing positive, clinically relevant outcomes were reviewed.

Special Note 2: As no one has performed a comprehensive dose-response study, the lower or upper bound of clinical effectiveness is not known.

HRW (Bath)

· Note 1: most studies were conducted at 40 C/104 F

· Note 2: On average, clinically-relevant improvements were observed with 10 minutes of bathing.

· psoriasis: Bathed in HRW twice a week, at an interval of 3 days, for 10-15 minutes each immersion (365)

· acne: HRW applied to skin in the form of a soaked patch for 10 min or as a stream of water (jet) for 5 min. Treated once a week for four weeks (6)

· heat retention (in the body after bathing): Bathed in HRW for 10 minutes (13)

· Improvement in skin blotchiness: Immersion in HRW for 10 minutes from 1-3 times per day every day (158)

· keratin plugs and surface blood circulation: Bathed in HRW for 10 minutes once a day for 7 days (340)

· UV-induced skin damage: Affected skin was immersed in HRO for 2 hours (729)

· acne: HRW applied to affected area for 10-30 seconds twice daily (981)

· oxidative and autoimmune markers: Bathed in HRW for 10 minutes daily (1123)

· muscle damage and soreness after exercise: Bathed in HRW for 30 min (131)

HRW (Ingestion)

· Note: Dosages tended to range from 500 mL to 2 L per day, with an average of 1 L per day.

· Unstable angina: 1000-1200 mL/d for three months (28)

· Endothelial function: 500 mL per day for 14 days (69)

· General quality of life: 600 mL/day for four weeks (318)

· Parkinson’s symptoms: 1000 mL/day for 8 weeks (354, 529, 748)

· Exercise-induced oxidative stress: 1000 mL following exercise (336)

· Exercise-induced oxidative stress: 600 mL per exercise session (431)

· Exercise-induced fatigue: 1380 mL per exercise session (1143)

· Exercise-induced fatigue: 1000 mL per exercise session (59)

· Exercise-induced fatigue: 500 mL/bottle three times per day (1500 mL/day total) (1083)

· Exercise-induced fatigue: 600 mL per exercise session (161)

· Exercise performance enhancement: 500 mL per day for two weeks (67, 1345)

· Exercise performance enhancement: 1000 mL/day (1166)

· Exercise performance enhancement: 2 mL/kg/15 min for each 60 min exercise session (71)

· Exercise performance enhancement: 2 L/day for two weeks (275)

· Exercise performance enhancement: 1260-2520 mL/day (1362)

· Chemo-induced liver injury: 1000 mL/day for 4 days (451)

· Hypoxia-induced brain injury: 5 mL/kg/day for 10 days (527)

· Rheumatoid arthritis: 530 mL/day for four weeks (770)

· Hyperuricemia: three 330 mL bottles/day for 8 weeks (990 mL/day) (1414)

· Hypercholesterolemia: 0.9 L/day (0.3 L/ three times per day) for 10 weeks (587)

· Diabetes Type II: 900 mL/day for 8 weeks (956)

· Diabetes Type II: 1500 mL/day for 8 weeks (47)

· Diabetes Type II: 1500-2000 mL/day (1139)

· Metabolic disorder: 1000 mL/day for 8 weeks (1301)

· Metabolic disorder: 1050 ml/day for three months (1347)

· Retinal Injury: 400-500 mL twice daily (800-1000 mL total) for four weeks (1324)

· Intraocular pressure: 1260 mL/day (administered in three doses) (1311)

· Workplace-induced oxidative stress: 1.5 L/day for eight weeks (56)

· Asthma: 1200 mL/day for 14 days (227)

· Myopathy: 1 L/day for 12 weeks (839)

· COVID-19 fatigue: 500 mL/twice day (1000 mL/day) for 14 days (1371)

· Graft-vs-host disease: 4 ml/kg three times per day (114)

· Dementia: 300 ml/day for 1 year (324)

· General inflammation: 1.5 L/day for 4 weeks (123)

· Obesity: 7.5 mg/day (1310)

· Psoriasis: 500 ml (5-7 ppm)/day (554)

H2 Gas (Inhalation)

· Note: Dosages and treatment times vary considerably across studies.

· Addiction: 150 mL/min gas flow rate at 2 h/day/3 months (1408)

· Addiction: 150 mL/min, 2h/day/3 months (1221)

· Aging: 15 min/day/4 weeks (86)

· Aging: 66% H2/33% O2, 4 h/day/2 weeks (1213)

· Alzheimer’s Disease: 3% H2/97% O2, 2 hr/day/6 months (1253)

· Alzheimer’s Disease: 66% H2/33% O2, once per day/6 days per week/for 4 weeks (1287)

· Alzheimer’s Disease: 2% H2/98% O2, 30 min/day/4 weeks (1300)

· Cancer: 5% H2/95% O2, 30 min/day (9)

· Cancer: 3 h/day (43)

· Cancer: 66% H2/33% O2, 3 L/min, 4h/day/2 weeks (52)

· Cancer: 66% H2/33% O2, 3L/min, 4-6 h/day/5 months (93)

· Cancer: 66% H2/33% O2, 3h/d (157)

· Cancer: 66% H2/33% O2, 3L/min, 3-6 h/d/4 months (168)

· Cancer: 3L/min, 2-6 h/day (169)

· Cancer: 66% H2/33% O2, 3L/min, 3-6 h/d/1 month (170)

· Cancer: 66% H2/33% O2, 3L/min, 3-6 h/d/3 months (171)

· Cancer: 5% H2/95% O2, 30 min/day (188)

· Cancer: 66% H2/33% O2, 3-6 h/day/4-12 weeks (1173)

· Cancer: 66% H2/33% O2, 3L/min, 4 h/day/2 months (1318)

· Cancer: 66% H2/33% O2, 2 h/day (1409)

· Cardiac Arrest: 2% H2/98% O2, 18 h (128)

· Cardiac Arrest: 2% H2/98% O2, 18 h (1257)

· COPD: 66% H2/33% O2, 6 h/day/7 days (41)

· COPD: 2% H2/98% O2, 45 min/day (136)

· COPD: 73% H2/27% O2, 1.5 h/day (1348)

· Coma: 66% H2/33% O2, 4-6 h/day (1147)

· Diabetes Type II: 25 h/week (1266)

· Diabetes Type II: 3 L/H (1294)

· Exercise: 1% H2, 20 min/during session (66)

· Exercise: 4% H2, 45 ml/min, 30 min/day/7 days (199)

· Exercise: 4% H2, 1800 ml/min, 60 min/during recovery (1175)

· Exercise: 20 min/before session (1354)

· Exercise: 4% H2, 60 min/before session (1398)

· Hearing Loss: 3% H2, 2h/day/6 days (1220)

· Cerebral Ischemia: 4%, 30 min (790)

· General safety in healthy adults: 2.4% H2, 24-72 hours (1093)

· Interstitial Lung Disease: 1.6 ppm

· Liver Disease: 66% H2/33% O2, 1 h/day/13 weeks (1181)

· Myalgic Encephalomyelitis/Chronic Fatigue: 6-7% H2, 3-5 h/day (1332)

· Stroke: 18-24 h/day (1274)

· Parkinson’s Disease: 3% H2, 20 min/day/4 weeks (189)

· Parkinson’s Disease: 6-7% H2, 20-90 min/day/3-5 weeks (1394)

· Wound heading: 2h/d/6 months (1202)

· Rhinitis: 66% H2, 3h d/4 weeks (1420)

· SARS/COVID: 66% H2, daily, until discharge (62)

· SARS/COVID: 66% H2 (1145)

· SARS/COVID: 100% H2/2 hr/day/5d-6 months (1148)

· SARS/COVID: 66% H2, 6h/d/7 days (1304)

· SARS/COVID: 66% H2/7h/d (1329)

· SARS/COVID: 3.6% H2, 24 h/day, 1-6 days (1402)

· Surgery: 1.5-2% H2, ~1 hr/during operation (1084)

· Surgery: 1.5-2% H2, during operation (1198)

· Surgery: 66% H2, 1 h, prior to operation (1262)

· Vasculitis: 77% H2, 1 h/d/4 months (1178)