Studies Referencing Hydrogen and Urinary, Liver, Detox

Database:

Primary Topic: Bladder/Kidney/Liver

Secondary Topic: Bladder Outlet Obstruction/Painful Bladder Syndrome/Acute Kidney Injury/Chronic Kidney Disease/ Haemodialysis/Kidney Failure/Kidney Stones/Liver Injury/Alcoholic Liver Disease/Fatty Liver Disease (Alcoholic)/Fatty Liver Disease (Nonalcoholic)/Hepatitis B/Hepatitis, Autoimmune/Liver Disease/Liver Failure/Liver Function/Obstructive Jaundice/Non-Alcoholic Steatohepatitis (NASH) (or Any)

Tertiary Topic: Intersitial Cystitis/Acute Tubuluar Necrosis/Congenital Obstructive Nephropathy/Diabetic Nephropathy/Glomerulosclerosis/Oxalate Injury/Ureteral Obstruction/Alcohol Toxicity/Bile Duct Injury/Fatty Liver Disease (Nonalcoholic)/Portal Hypertension/Postoperative Liver Failure/Xenobiotic Clearance/Cirrhosis (or Any)

 

Bladder Issues

● Hydrogen has been shown to improve bladder issues including bladder outlet obstruction (506: Miyazaki et al 2016) and painful bladder syndrome/interstitial cystitis (719: Matsumoto, Ueda, and Kakizaki 2013).

 

Kidney Issues

● Hydrogen has been shown to improve kidney issues including

• acute tubular necrosis (139: Wu, Fang, and Zhou 2020),
• burn-induced shock (345: Wang et al 2018; 546: Guo et al 2015),
• fibrosis (372: Chen et al 2017; 445: Xing et al 2017),
• ischemia-reperfusion injury (497: Li et al 2016; 245: Xu et al 2019; 323: Nishida et al 2018; 680: Zeng et al 2014; 688: Akdeniz et al 2013; 878: Wang et al 2011; 917: Shingu et al 2010; 1165: Kinoshita et al 2022),
• pancreatitis-associated kidney injury (584: Shi et al 2015),
• rhabdomyolysis-associated kidney injury (630: Gu et al 2014),
• ureteral obstruction (742: Xu et al 2013),
• congenital obstructive nephropathy (1048: Mizutani et al 2021),
• chronic kidney disease (267: Chen et al 2018),
• diabetic nephropathy (11: Indrajani et al 2021; 776: Katakura et al 2012),
• melamine toxicity (883: Yoon et al 2011),
• hypertension-associated kidney injury (674: Xin et al 2014; 756: Zhu et al 2013; 928: Zhu et al 2010),
• metabolic acidosis (929: Abol-Enein et al 2009),
• no-reflow syndrome (25: Rohovyi et al 2021),
• kidney failure (68: Imamura et al 2020),
• kidney stones (575: Peng et al 2015; 1085: Si et al 2021; 1174: Lu et al 2018),
• metabolic syndrome-associated glomerulosclerosis (833: Hashimoto et al 2011),
• polycystic kidney disease (246: Yamasaki et al 2019),
• gamma radiation damage (631: Guo et al 2014),
• sepsis (253: Yao et al 2019; 651: Liu et al 2014),
• and sleep apnea-associated kidney injury (183: Guan et al 2019; 184: Guan et al 2019).

Liver Issues

● Hydrogen has been shown to improve liver issues including

• alcohol toxicity (1030: Yano et al 2021; 38: Zhang et al 2021; 404: Lin et al 2017), cirrhosis (645: Lee et al 2014; 871: Sun et al 2011),
• pesticide toxicity (i.e. Chlorpyrifos (142: Xun et al 2020)),
• chemical toxicity (i.e. carbon tetrachloride (1135: Wang et al 2021)),
• fatty liver disease (404: Lin et al 2017; 310: Li et al 2018; 207: Korovljev et al 2019; 438: Wang and Wang 2017; 461: Zhai et al 2017; 98: Liu et al 2020; 298: Jackson et al 2018; 486: Hou et al 2016; 143: Gang 2019),
• food poisoning/aflatoxicosis (191: Hu et al 2019), hepatitis (740: Xia et al 2013; 934: Kajiya et al 2009),
• burn-induced (647: Liu et al 2014) and hemorrhagic (378: Dang et al 2017) shock,
• fibrosis (642: Koyama et al 2014; 948: Tsai et al 2009; 1088: Li et al 2021),
• pancreatitis-associated liver injury (515: Shi et al 2016),
• non-alcoholic steatohepatitis (NASH) (18: Li et al 2021; 708: Kawai, Takaki, and Yamamoto 2013; 779: Kawai et al 2012),
• obstructive jaundice (501: Liu et al 2016; 904: Liu et al 2010; 262: Zhu et al 2019),
• parasite infection (997: Gharib et al 2001),
• sepsis (394: Iketani et al 2017; 743: Xu and Zhang 2013; 247: Yan et al 2019),
• sleep apnea associated liver injury (452: Yang et al 2017),
• and ischemia-reperfusion injury (151: Zhang et al 2020; 219: Maly et al 2019; 258: Zhang et al 2019; 266: Bai et al 2018; 285: Ge et al 2018; 307: Li et al 2018; 359: Zhang et al 2018; 385: Golshahi et al 2017; 401: Li et al 2017; 409: Lu et al 2017; 605: Yu et al 2015; 613: Zhang et al 2015; 652: Liu et al 2015; 804: Tanabe et al 2012; 809: Xiang et al 2012; 863: Nishimura et al 2011; 962: Fukuda et al 2007).

● Hydrogen has been shown to increase the rate of xenobiotic clearance from the liver (250: Yao et al 2019).

● Long-term, daily use of hydrogen has been shown to favorably reprogram liver metabolism (1156: Adzavon et al 2022).

 

Cancer

● Hydrogen has shown efficacy as a carcinostatic in kidney (712: Li et al 2013), bladder (1075: Sun et al 2020), and liver (33: Wu et al 2021) cancers.

● Hydrogen alleviates chemotherapy-induced hepatotoxicity (specifically mFOLFOX6 (451: Yang et al 2017) and Doxorubicin (476: Gao et al 2016) treatments) and nephrotoxicity (specifically Cisplatin treatment (271: Cheng et al 2018; 860: Matsushita et al 2011; 902: Kitamura et al 2010; 942: Nakashima-Kamimura et al 2009)).

 

Surgery and Transplantation

● Hydrogen can alleviate drug-induced nephrotoxicity including antibiotic toxicity (i.e. Gentamicin) (859: Matsushita et al 2011), contrast media toxicity (i.e. Loversol (551: Homma et al 2015)), and immunosuppressant toxicity (i.e. Cyclosporine A (104: Lu et al 2020)).

● Hydrogen can alleviate Acetaminophen-induced hepatotoxicity (617: Zhang et al 2015).

● Hydrogen has been shown to effectively prevent morbidities resulting from the transplantation of kidney tissue (891: Cardinal et al 2010; 206: Kobayashi and Sano 2019; 758: Abe et al 2012; 82: Kawamura et al 2020; 24: Nishi et al 2021) and liver tissue (239: Uto et al 2019; 297: Ishikawa et al 2018; 339: Tamaki et al 2018; 516: Shimada et al 2016; 655: Matsuno et al 2014).

● Hydrogen protects the organs from inflammation and morbidity associated with surgery and other medical procedures, including the kidneys (175: Cole et al 2019; 542: Du et al 2015) and liver (376: Chen et al 2017; 665: Tan et al 2014).

● Hydrogen has been shown to be a safe addition to hemodialysis (964: Nakayama et al 2007; 320: Nakayama et al 2018) solutions in order to

• reduce inflammation and oxidative stress (943: Nakayama et al 2009; 969: Huang et al 2006; 502: Maeda et al 2016; 909: Nakayama et al 2010; 985: Huang et al 2003; 667: Terawaki et al 2014)
• and immune dysfunction (897: Huang et al 2010),
• improve blood pressure (943: Nakayama et al 2009; 418: Nakayama et al 2017; 909: Nakayama et al 2010),
• and increase detoxification and clearance (591: Tange, Takesawa, and Yoshitake 2015).

● Hydrogen has been shown to improve liver regeneration after partial hepatectomy (606: Yu et al 2015).

 

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (476: Gao et al 2016; 506: Miyazaki et al 2016; 139: Wu, Fang, and Zhou 2020; 546: Guo et al 2015; 584: Shi et al 2015; 630: Gu et al 2014; 742: Xu et al 2013; 245: Xu et al 2019; 776: Katakura et al 2012; 674: Xin et al 2014; 756: Zhu et al 2013; 575: Peng et al 2015; 631: Guo et al 2014; 651: Liu et al 2014; 183: Guan et al 2019; 551: Homma et al 2015; 104: Lu et al 2020; 680: Zeng et al 2014; 878: Wang et al 2011; 891: Cardinal et al 2010; 82: Kawamura et al 2020; 985: Huang et al 2003; 665: Tan et al 2014; 376:Chen et al 2017; 339: Tamaki et al 2018; 645: Lee et al 2014; 142: Xun et al 2020; 404: Lin et al 2017; 191: Hu et al 2019; 740: Xia et al 2013; 642: Koyama et al 2014; 871: Sun et al 2011; 617: Zhang et al 2015; 515: Shi et al 2016; 779: Kawai et al 2012; 904: Liu et al 2010; 997: Gharib et al 2001; 606: Yu et al 2015; 394: Iketani et al 2017; 743: Xu and Zhang 2013; 378: Dang et al 2017; 452: Yang et al 2017; 258: Zhang et al 2019; 652: Liu et al 2015),

increasing the activity of endogenous antioxidant enzymes (271: Cheng et al 2018; 546: Guo et al 2015; 630: Gu et al 2014; 742: Xu et al 2013; 245: Xu et al 2019; 674: Xin et al 2014; 575: Peng et al 2015; 104: Lu et al 2020; 878: Wang et al 2011; 985: Huang et al 2003; 665: Tan et al 2014; 376: Chen et al 2017; 297: Ishikawa et al 2018; 142: Xun et al 2020; 404: Lin et al 2017; 191: Hu et al 2019; 948: Tsai et al 2009; 617: Zhang et al 2015; 515: Shi et al 2016; 904: Liu et al 2010; 997: Gharib et al 2001; 606: Yu et al 2015; 656: Nakai et al 2014; 452: Yang et al 2017; 258: Zhang et al 2019; 266: Bai et al 2018; 285: Ge et al 2018; 385: Golshahi et al 2017),

upregulating cellular protection mechanisms (445: Xing et al 2017; 497: Li et al 2016; 245: Xu et al 2019; 68: Imamura et al 2020; 575: Peng et al 2015; 253: Yao et al 2019; 104: Lu et al 2020; 404: Lin et al 2017; 310: Li et al 2018; 438: Wang and Wang 2017; 461: Zhai et al 2017; 18: Li et al 2021; 401: Li et al 2017; 605: Yu et al 2015; 613: Zhang et al 2015; 1135: Wang et al 2021),

counteracting inflammation and apoptosis (139: Wu, Fang, and Zhou 2020; 345: Wang et al 2018; 546: Guo et al 2015; 497: Li et al 2016; 584: Shi et al 2015; 630: Gu et al 2014; 674: Xin et al 2014; 756: Zhu et al 2013; 68: Imamura et al 2020; 575: Peng et al 2015; 1085: Si et al 2021; 651: Liu et al 2014; 551: Homma et al 2015; 104: Lu et al 2020; 323: Nishida et al 2018; 878: Wang et al 2011; 891: Cardinal et al 2010; 82: Kawamura et al 2020; 542: Du et al 2015; 985: Huang et al 2003; 665: Tan et al 2014; 376: Chen et al 2017; 297: Ishikawa et al 2018; 516: Shimada et al 2016; 645: Lee et al 2014; 404: Lin et al 2017; 310: Li et al 2018; 461: Zhai et al 2017; 191: Hu et al 2019; 934: Kajiya et al 2009; 647: Liu et al 2014; 871: Sun et al 2011; 617: Zhang et al 2015; 515: Shi et al 2016; 779: Kawai et al 2012; 904: Liu et al 2010; 997: Gharib et al 2001; 606: Yu et al 2015; 394: Iketani et al 2017; 743: Xu and Zhang 2013; 378: Dang et al 2017; 285: Ge et al 2018; 359: Zhang et al 2018; 385: Golshahi et al 2017; 401: Li et al 2017; 613: Zhang et al 2015; 652: Liu et al 2015; 809: Xiang et al 2012),

improving immune function (253: Yao et al 2019; 651: Liu et al 2014; 183: Guan et al 2019; 897: Huang et al 2010; 647: Liu et al 2014),

restoring mitochondrial (674: Xin et al 2014; 917: Shingu et al 2010; 297: Ishikawa et al 2018; 516: Shimada et al 2016; 142: Xun et al 2020; 486: Hou et al 2016; 501: Liu et al 2016; 743: Xu and Zhang 2013; 247: Yan et al 2019)

and endoplasmic reticulum (184: Guan et al 2019; 307: Li et al 2018; 409: Lu et al 2017) function,

and regulating the gut microbiome (1088: Li et al 2021).

 

Literature Cited (numbered as per database):

● (11) Indrajani, Olly; Retnaningtyas, Ekowati; Santoso, Hendry; Setyabudhi, Veronica Verina. Hydrogen water therapy in histopathological improvement of diabetic nephropathy on streptozotocin-induced diabetic rats. 2021. AIP Conference Proceedings. 10.1063/5.0053002

● (18) Li, Shao-Wei; Takahara, Terumi; Que, Weitao; Fujino, Masayuki; Guo, Wen-Zhi; Hirano, Shin-Ichi; Ye, Li-Ping; Li, Xiao-Kang. Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling. 2021. American Journal of Physiology: Gastrointestinal and Liver Physiology. 10.1152/ajpgi.00158.2020

● (24) Nishi, Kotaro; Iwai, Satomi; Tajima, Kazuki; Okano, Shozo; Sano, Motoaki; Kobayashi, Eiji. Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model. 2021. Frontiers in Immunology. 10.3389/fimmu.2020.626295

● (25) Rohovyi, Yu.; Tsitrin, V.; Arkchipova, L.; Bilookyi, V.; Kolesnik, O. THE USE OF MOLECULAR HYDROGEN IN CORRECTION OF NO-REFLOW SYNDROME IN THE POLYURIC STAGE OF SUBLIMATE NEPHROPATHY. 2021. Georgian Medical News. 33814411

● (33) Wu, Ying; Su, Lichao; Yuan, Meng; Chen, Tao; Ye, Jiamin; Jiang, Yifan; Song, Jibin; Yang, Huanghao. In vivo X-ray triggered catalysis of H2 generation for cancer synergistic gas-radiotherapy. 2021. Angewandte Chemie. 10.1002/anie.202100002

● (38) Zhang, Yaxing; Bi, Mingmin; Chen, Zifeng; Dai, Min; Zhou, Ge; Hu, Yuxuan; Yang, Hongzhi; Guan, Weibing. Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation. 2021. Experimental and Therapeutic Medicine. 10.3892/etm.2021.9884

● (68) Imamura, Ryoichi; Kawamura, Masataka; Taniguchi, Ayumu; Kobayashi, Yuki; Nakazawa, Shigeaki; Kato, Taigo; Abe, Toyofumi; Uemura, Motohide; Kobayashi, Hikaru; Nonomura, Norio. Efficacy of a Si-based agent against developing renal failure in a rat remnant kidney model. 2020. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2020.10.067

● (82) Kawamura, Masataka; Imamura, Ryoichi; Kobayashi, Yuki; Taniguchi, Ayumu; Nakazawa, Shigeaki; Kato, Taigo; Namba-Hamano, Tomoko; Abe, Toyofumi; Uemura, Motohide; Kobayashi, Hikaru; Nonomura, Norio. Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method. 2020. Frontiers in Medicine. 10.3389/fmed.2020.00095

● (98) Liu, Boyan; Xue, Junli; Zhang, Mengyu; Wang, Mingyue; Ma, Tingting; Zhao, Min; Gu, Qianqian; Qin, Shu-Cun. Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats. 2020. Molecular Medicine Reports. 10.3892/mmr.2020.11364

● (104) Lu, Yi; Li, Chun-Fang; Ping, Na-Na; Sun, Yu-Yao; Wang, Zheng; Zhao, Gong-Xiao; Yuan, Shi-Hui; Zibrila, Adoulaye Issotina; Soong, Lynn; Liu, Jin-Jun. Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway. 2020. Journal of Biochemical and Molecular Toxicology. 10.1002/jbt.22467

● (139) Wu, Song; Fang, Zheng; Zhou, Shujun. Saturated hydrogen alleviates CCl 4 -induced acute kidney injury via JAK2/STAT3/p65 signaling. 2020. Journal of International Medical Research. 10.1177/0300060519895353

● (142) Xun, Zhi-Ming; Xie, Fei; Zhao, Peng-Xiang; Liu, Meng-Yu; Li, Zhi-Yuan; Song, Jian-Mei; Kong, Xian-Min; Ma, Xue-Mei; Li, Xiao-Yang. Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats. 2020. Annals of Agricultural and Environmental Medicine. 10.26444/aaem/125504

● (143) Gang, Cui. Abstract: Oral Hydrogen water – reduce hepatic inflammatory cells in mouse. 2019. HPB. 10.1016/j.hpb.2019.10.2018

● (151) Zhang, Jiantao; Zheng, Xiaoyan; Jiang, Lihong; Tao, Ze; Liu, Tao. Protective effects of hydrogen on oxidative stress and liver function during CO2 pneumoperitoneum in dogs. 2020. Medycyna Weterynaryjna. 10.21521/mw.6459

● (175) Cole, Alexis R.; Perry, Dorothy A.; Raza, Ali; Nedder, Arthur P.; Pollack, Elizabeth; Regan, William L.; van den Bosch, Sarah J.; Polizzotti, Brian D.; Yang, Edward; Davila, Daniel; Afacan, Onur; Warfield, Simon K.; Ou, Yangming; Sefton, Brenda; Everett, Allen D.; Neil, Jeffrey J.; Lidov, Hart G.W.; Mayer, John E.; Kheir, John N. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. 2019. JACC Basic to Translational Research. 10.1016/j.jacbts.2018.11.006

● (183) Guan, Peng; Sun, Zhi-Min; Luo, Li-Fei; Zhao, Ya-Shuo; Yang, Sheng-Chang; Yu, Fu-Yang; Wang, Na; Ji, En-Sheng. Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload. 2019. Molecules. 10.3390/molecules24061184

● (184) Guan, Peng; Sun, Zhi-Min; Luo, Li-Fei; Zhou, Jian; Yang, Shengchang; Zhao, Ya-Shuo; Yu, Fu-Yang; An, Ji-Ren; Wang, Na; Ji, En-Sheng. Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis. 2019. Life Sciences. 10.1016/j.lfs.2019.04.005

● (191) Hu, Hong-Lei; Gao, Jian; Guo, Wen-Jun; Zhou, Feng-Hua; Liu, Hong-Yan; Su, Chang-Chun. Anti-injury effect of hydrogen-enriched water in a rat model of liver injury induced by aflatoxin B1. 2019. Acta Physiologica Sinica. 31646326

● (206) Kobayashi, Eiji; Sano, Motoaki. Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs. 2019. PLoS One. 10.1371/journal.pone.0222863

● (207) Korovljev, Darinka; Stajer, Valdemar; Ostojic, Jelena; LaBaron, Tyler W.; Ostojic, Sergej M. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. 2019. Gastroenterology Clinical Biology. 10.1016/j.clinre.2019.03.008

● (219) Maly, Ondrej; Zajak, Jan; Hyspler, Radomir; Turek, Zdenek; Astapenko, David; Jun, Daniel; Vanova, Nela; Kohout, Ales; Radochova, Vera; Kotek, Jiri; Paral, Jiri. Inhalation of molecular hydrogen prevents ischemia-

reperfusion liver damage during major liver resection. 2019. Annals of Translational Medicine. 10.21037/atm.2019.11.43

● (239) Uto, Keiichi; Sakamoto, Seisuke; Que, Weitao; Shimata, Keita; Hashimoto, Shintaro; Sakisaka, Masataka; Narita, Yasuko; Yoshii, Daiki; Zhong, Lin; Komohara, Yoshihiro; Li, Xiao-Kang; Inomata, Yukihiro; Hibi, Taizo. Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation. 2019. BMC Gastroenterology. 10.1186/s12876-019-0939-7

● (245) Xu, Xianlin; He, Xiaozhou; Liu, Jipu; Qin, Jiandi; Ye, Jianan; Fan, Min. Protective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased expression of heme oxygenase-1 in aged rats. 2019. International Journal of Clinical and Experimental Pathology. 31933966

● (246) Yamasaki, Masatora; Miyazono, Motoaki; Yoshihara, Maki; Suenaga, Atsuhiko; Mizuta, Masato; Fukuda, Makoto; Rikitake, Shuichi; Ikeda, Yuji. Effects of hydrogen-rich water in a rat model of polycystic kidney disease. 2019. PLoS One. 10.1371/journal.pone.0215766

● (247) Yan, Mengying; Yu, Yang; Mao, Xing; Feng, Jingcheng; Wang, Yanyan; Chen, Hongguang; Xie, Keliang; Yu, Yong-Hao. Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. 2019. International Immunopharmacology. 10.1016/j.intimp.2019.03.021

● (250) Yao, Hsien-Tsung; Yang, Yu-Hsuan; Li, Mei-Ling. Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver. 2019. Molecules. 10.3390/molecules24142627

● (253) Yao, Weifeng; Guo, Anshun; Han, Xue; Wu, Shan; Chen, Chaojin; Luo, Chenfang; Li, Haobo; Li, Shangrong; Hei, Ziqing. Aerosol inhalation of a hydrogen-rich solution restored septic renal function. 2019. Aging. 10.18632/aging.102542

● (258) Zhang, Qianzhen; Piao, Chenxi; Xu, Jiayuan; Jiao, Zhihui; Ge, Yansong; Liu, Xiaoning; Ma, Yajun; Wang, Hong-Bin. Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on hepatic ischemia-reperfusion and hepatectomy injury in swine. 2019. Biomedicine and Pharmacotherapy. 10.1016/j.biopha.2019.109453

● (262) Zhu, Shiyang; Yu, Jianhua; Lin, Weiguo; Tang, Haijun; Zhang, Weiguang; Lu, Baochun. Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions. 2019. Molecular Medicine Reports. 10.3892/mmr.2019.10179

● (266) Bai, Ge; Li, Hui; Ge, Yansong; Zhang, Qianzhen; Zhang, Jiantao; Chen, Mingzi; Liu, Tao; Wang, Hong-Bin. Influence of Hydrogen-rich Saline on Hepatocyte Autophagy During Laparoscopic Liver Ischaemia-reperfusion Combined Resection Injury in Miniature Pigs. 2018. Journal of Veterinary Research. 10.2478/jvetres-2018-0056

● (267) Chen, Bo; Song, Dong; Ma, Juan; Zhu, Wanjun. Molecular Hydrogen Suppresses Renal Injury in Chronic Kidney Disease Rats. 2018. Journal of Bioprocessing and Biotechniques. 10.4172/2155-9821.1000331

● (271) Cheng, Tse-Chou; Hsu, Yu-Wen; Lu, Fung-Jou; Chen, Ya-Yu; Tsai, Nu-Man; Chen, Wen-Kang; Tsai, Chia-Fang. Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice. 2018. Journal of the Chinese Medical Association. 10.1016/j.jcma.2017.08.014

● (285) Ge, Yan-Song; Zhang, Qian-Zhen; Li, Hui; Bai, Ge; Jiao, Zhi-Hui; Wang, Hong-Bin. Hydrogen-rich saline protects against hepatic injury induced by ischemia-reperfusion and laparoscopic hepatectomy in swine. 2018. Hepatobiliary and Pancreatic Diseases. 10.1016/j.hbpd.2018.12.001

● (297) Ishikawa, Takahisa; Shimasa, Shingo; Fukai, Moto; Kimura, Taichi; Umemoto, Kouhei; Shibata, Kengo; Fujiyoshi, Masato; Fujiyoshi, Sunao; Hayasaka, Takahiro; Kawamura, Norio; Kobayashi, Nozomi; Shimamura, Tsuyoshi; Taketomi, Akinobu. Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. 2018. Surgery Today. 10.1007/s00595-018-1693-0

● (298) Jackson, Karen; Dressler, Noa; Ben-Shushan, Rotem S.; Meerson, Ari; LeBaron, Tyler W.; Tamir, Snait. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. 2018. World Journal of Gastroenterology. 10.3748/wjg.v24.i45.5095

● (307) Li, Hui; Bai, Ge; Ge, Yansong; Zhang, Qianzhen; Kong, Xiangdong; Meng, Weijing; Wang, Hong-Bin. Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress. 2018. Life Sciences. 10.1016/j.lfs.2017.12.022

● (310) Li, Shaowei; Fujino, Masayuki; Ichimaru, Naotsugu; Kurakawa, Ryosuke; Hirano, Shinichi; Mou, Lisha; Takahara, Shiro; Takahara, Terumi; Li, Xiao-Kang. Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression. 2018. Nature Scientific Reports. 10.1038/s41598-018-32411-4

● (320) Nakayama, Masaaki; Itami, Noritomo; Suzuki, Hodaka; Hamada, Hiromi; Yamamoto, Ryo; Tsunoda, Kazumasa; Osaka, Naoyuki; Nakano, Hirofumi; Maruyama, Yukio; Kabayama, Shigeru; Nakazawa, Ryoichi; Miyazaki, Mariko; Ito, Sadayoshi. Novel haemodialysis (HD) treatment employing molecular hydrogen (H 2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. 2018. Nature Scientific Reports. 10.1038/s41598-017-18537-x

● (323) Nishida, T.; Hayashi, T.; Inamoto, T.; Kato, R.; Ibuki, N.; Takahara, K.; Takai, T.; Yoshikawa, Y.; Uchimoto, T.; Saito, K.; Tanda, N.; Kouno, J.; Minami, K.; Uehara, H.; Hirano, H.; Nomi, H.; Okada, Y.; Azuma, H. Dual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From Renal Ischemia-Reperfusion Injury. 2018. Transplantation Proceedings. 10.1016/j.transproceed.2017.12.014

● (339) Tamaki, Ichiro; Hata, Koichiro; Okamura, Yusuke; Nigmet, Yermek; Hirao, Hirofumi; Kubota, Toyonari; Inamoto, Osamu; Kusakabe, Jiro; Goto, Toru; Tajima, Tetsuya; Yoshikawa, Junichi; Tanaka, Hirokazu; Tsuruyama, Tatsuaki; Tolba, Rene H.; Uemoto, Shinji. Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury. 2018. Liver Transplantation. 10.1002/lt.25326

● (345) Wang, L.L.; Guo, S.X.; Wu, P.; Shao, H.W.; Han, Chun-Mao. Influences of hydrogen-rich saline on acute kidney injury in severely burned rats and mechanism. 2018. Chinese Journal of Burns. 10.3760/cma.j.issn.1009-2587.2018.09.013

● (359) Zhang, Qianzhen; Ge, Yansong; Li, Hui; Bai, Ge; Jiao, Zhihui; Kong, Xiangdong; Meng, Weijing; Wang, Hong-Bin. Effect of hydrogen-rich saline on apoptosis induced by hepatic ischemia reperfusion upon laparoscopic hepatectomy in miniature pigs. 2018. Research in Veterinary Science. 10.1016/j.rvsc.2018.07.005

● (372) Chen, Jing; Zhang, Han; Hu, Jianchang; Gu, Yulu; Shen, Ziyan; Xu, Linghan; Jia, Xueqi; Zhang, Xiaoyan; Ding, Xiaoqiang. Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression. 2017. Frontiers in Pharmacology. 10.3389/fphar.2017.00499

● (376) Chen, Mingzi; Jiang, Lihong; Li, Yue; Bai, Ge; Zhao, Jinghua; Zhang, Ming; Zhang, Jiantao. Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats. 2017. Oncotarget. 10.18632/oncotarget.23498

● (378) Dang, Yangjie; Liu, Ting; Mei, Xiaopeng; Meng, Xiangzhong; Guo, Xingchun; Deng, Bin; Xu, Hao; Xu, Lixian. Hyperoxygenated hydrogen-rich solution suppresses shock- and resuscitation-induced liver injury. 2017. Journal of Surgical Research. 10.1016/j.jss.2017.07.022

● (385) Golshahi, Hannaneh; Tavasoly, Abbas; Mardjanmehr, Seyed Hossein; Abdi, Khosrou M.; Dehghan, Mohammad Mehdi; Mohajeri, Saeed Farzad. Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model. 2017. Brazilian Journal of Veterinary Pathology. 10.24070/bjvp.1983-0246.v10i1p10-21

● (394) Iketani, Masumi; Ohshiro, Jumi; Urushibara, Takuya; Takahashi, Mayumi; Arai, Tomio; Kawaguchi, Hideo; Ohsawa, Ikuroh. Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury. 2017. Shock. 10.1097/SHK.0000000000000810

● (401) Li, He; Chen, Ouyang; Ye, Zhouheng; Zhang, Rongjia; Hu, Huijun; Zhang, Ning; Guang, Junlong; Liu, Wenwu; Sun, Xue-Jun. Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway. 2017. Biochemical Pharmacology. 10.1016/j.bcp.2017.02.003

● (404) Lin, Ching-Pin; Chuang, Wen-Chen; Lu, Fung-Jou; Chen, Chih-Yen. Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice. 2017. World Journal of Gastroenterology. 10.3748/wjg.v23.i27.4920

● (409) Lu, Zhiyuan; Lin, Yanzhu; Peng, Bo; Bao, Zhen; Niu, Kexin; Gong, Jia. Hydrogen-Rich Saline Ameliorates Hepatic Ischemia-Reperfusion Injury Through Regulation of Endoplasmic Reticulum Stress and Apoptosis. 2017. Digestive Diseases and Sciences. 10.1007/s10620-017-4811-8

● (418) Nakayama, Masaaki; Itami, Noritomo; Suzuki, Hodaka; Hamada, Hiromi; Osaka, Naoyuki; Yamamoto, Ryo; Tsunoda, Kazumasa; Nakano, Hirofumi; Watanabe, Kimio; Zhu, Wan-Jun; Maruyama, Yukio; Terawaki, Hiroyuki; Kabayama, Shigeru; Nakazawa, Ryoichi; Miyazaki, Mariko; Ito, Sadayoshi. Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. 2017. PLoS One. 10.1371/journal.pone.0184535

● (438) Wang, Xiang; Wang, Jiao. High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3. 2017. Biological Chemistry. 10.1515/hsz-2017-0303

● (445) Xing, Zhaoyu; Pan, Wanma; Zhang, Jing; Xu, Xianlin; Zhang, Xuemei; He, Xiaozhou; Fan, Min. Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt1. 2017. Biological and Pharmaceutical Bulletin. 10.1248/bpb.b16-00832

● (451) Yang, Qingxi; Ji, Guangdong; Pan, Rongtao; Zhao, Yinghui; Yan, Peng. Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. 2017. Molecular and Clinical Oncology. 10.3892/mco.2017.1409

● (452) Yang, S.C.; Chen, L.L.; Fu, T.; Li, W.Y.; Ji, En-Sheng. Improvement of hydrogen on liver oxidative stress injury in chronic intermittent hypoxia rats. 2017. Journal of Applied Physiology. 10.12047/j.cjap.5484.2018.016

● (461) Zhai, Xiao; Chen, Xiao; Lu, Jiancan; Zhang, Yaping; Sun, Xuejun; Huang, Qin; Wang, Qijin. Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ. 2017. Molecular Medicine Reports. 10.3892/mmr.2017.6120

● (476) Gao, Yunan; Yang, Hongxiao; Fan, Yanbin; Li, Lin; Fang, Jiahui; Yang, Wei. Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis. 2016. Mediators of Inflammation. 10.1155/2016/1320365

● (486) Hou, Chen; Wang, Yongyao; Zhu, Erkang; Yan, Chunhong; Zhao, Lin; Wang, Xiaojie; Qiu, Yingfeng; Shen, Hui; Sun, Xuejun; Feng, Zhihui; Liu, Jiankang; Long, Jiangang. Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. 2016. Biochemical Pharmacology. 10.1016/j.bcp.2015.12.020

● (497) Li, Jie; Hong, Zhijian; Liu, Hong; Zhou, Jihong; Cui, Lei; Yuan, Siming; Chu, Cianghua; Yu, Pan. Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation. 2016. Frontiers in Pharmacology. 10.3389/fphar.2016.00106

● (501) Liu, Qu; Li, Bao-Shan; Song, Yu-Jiao; Hu, Ming-Gen; Lu, Jian-Yue; Gao, Ang; Sun, Xue-Jun; Guo, Xi-Ming; Liu, Rong. Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice. 2016. Molecular Medicine Reports. 10.3892/mmr.2016.4954

● (502) Maeda, Kenji; Yoshizaki, Shigehito; Iida, Toshiro; Terada, Tomoyoshi; Era, Seiichi; Sakashita, Keiichiro; Arikawa, Hajime. Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study. 2016. Renal Replacement Therapy. 10.1186/s41100-016-0054-y

● (506) Miyazaki, Nozomu; Yamaguchi, Osamu; Nomiya, Masanori; Aikawa, Ken; Kimura, Junko. Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction. 2016. Journal of Urology. 10.1016/j.juro.2015.10.117

● (515) Shi, Qiao; Chen, Chen; Deng, Wen-Hong; Wang, Peng; Zuo, Teng; Zhao, Liang; Yu, Jia; Zhao, Kai-Liang; Mei, Fang-Chao; Li, Chen; Wang, Gui-Rong; Wang, Wei-Xing. Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase–dependent Reactive Oxygen Species. 2016. Pancreas. 10.1097/MPA.0000000000000678

● (516) Shimada, Shingo; Wakayama, Kenji; Fukai, Moto; Shimamura, Tsuyoshi; Ishikawa, Takahisa; Fukumori, Daisuke; Shibata, Maki; Yamashita, Kenichiro; Kimura, Taichi; Todo, Satoru; Ohsawa, Ikuroh; Taketomi, Akinobu.

Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver. 2016. Artificial Organs. 10.1111/aor.12710

● (542) Du, Hongyin; Sheng, Mingwei; Wu, Li; Zhang, Yamin; Shi, Dongjing; Weng, Yiqi; Xu, Rubin; Yu, Wenli. Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy. 2015. Transplantation. 10.1097/TP.0000000000001052

● (546) Guo, Song-Xue; Fang, Quan; You, Chuan-Gang; Jin, Yun-Yun; Wang, Xin-Gang; Hu, Xin-Lei; Han, Chun-Mao. Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. 2015. Journal of Translational Medicine. 10.1186/s12967-015-0548-3

● (551) Homma, Koichiro; Yoshida, Tadashi; Yamashita, Maho; Hayashida, Kei; Hayashi, Matsuhiko; Hori, Shingo. Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. 2015. Nephron Experimental Nephrology. 10.1159/000369068

● (575) Peng, Zhongjiang; Chen, Wei; Wang, Li; Ye, Zhouheng; Gao, Songyan; Sun, Xuejun; Guo, Zhiyong. Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice. 2015. International Journal of Clinical and Experimental Pathology. 26045773

● (584) Shi, Qiao; Liao, Kang-Shu; Zhao, Kai-Liang; Wang, Wei-Xing; Zuo, Teng; Deng, Wen-Hong; Chen, Chen; Yu, Jia; Guo, Wen-Yi; He, Xiao-Be; Abliz, Ablikim; Wang, Peng; Zhao, Liang. Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF- κ B Pathway. 2015. Mediators of Inflammation. 10.1155/2015/685043

● (591) Tange, Yoshihiro; Takesawa, Shingo; Yoshitake, Shigenori. Dialysate With High Dissolved Hydrogen Facilitates Dissociation of Indoxyl Sulfate From Albumin. 2015. Nephro-Urology Monthly. 10.5812/numonthly.26847

● (605) Yu, Jianhua; Zhang, Weiguang; Zhang, Rongguo; Jiang, Guixing; Tang, Haijun; Ruan, Xinxian; Ren, Peitu; Lu, Baochun. Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. 2015. Toxicology Letters. 10.1016/j.toxlet.2015.08.010’

● (606) Yu, Jianhua; Zhang, Weiguang; Zhang, Rongguo; Zhang, Rongguo; Ruan, Xinxian; Ren, Peitu; Lu, Baochun. Lactulose accelerates liver regeneration in rats by inducing hydrogen. 2015. Journal of Surgical Research. 10.1016/j.jss.2015.01.034

● (613) Zhang, Chao-Bin; Tang, Yi-Chen; Xu, Xue-Jun; Guo, Shi-Xiang; Wang, Huai-Zhi. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway. 2015. Experimental and Therapeutic Medicine. 10.3892/etm.2015.2385

● (617) Zhang, Jing-Yao; Song, Si-Dong; Pang, Qing; Zhang, Rui-Yao; Wan, Yong; Yuan, Da-Wei; Wu, Qi-Fei; Liu, Chang. Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. 2015. World Journal of Gastroenterology. 10.3748/wjg.v21.i14.4195

● (630) Gu, Hongxia; Yang, Min; Zhao, Xiaomin; Zhao, Bing, Sun, Xuejun; Gao, Xin. Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. 2014. Journal of Surgical Research. 10.1016/j.jss.2013.12.007

● (631) Guo, Jia-Ming; Yang, Yan-Yong; Liu, Wen; Gao, Fu; Cai, Jian-Ming; Zhao, Hua-Lin; Li, B.L. Protective effects of hydrogen-rich saline against γ-ray irradiation injury in HK-2 cells. 2014. Academic Journal of Second Military Medical University. 10.3724/SP.J.1008.2014.00963

● (642) Koyama, Yukinori; Taura, Kojiro; Hatano, Esturo; Tanabe, Kazutaka; Yamamoto, Gen; Nakamura, Kojiro; Yamanaka, Kenya; Kitamura, Koji; Narita, Masato; Nagata, Hiromitsu; Yanagida, Atsuko; Iida, Taku; Iwaisako, Keiko, Fujinawa, Hikohito; Uemoto, Shinji. Effects of oral intake of hydrogen water on liver fibrogenesis in mice. 2014. Hepatology Research. 10.1111/hepr.12165

● (645) Lee, Pei-Chang; Yang, Ying-Ying; Huang, Chien-Shang; Hsieh, Shie-Liang; Lee, Kuei-Chuan; Hsieh, Yun-Cheng; Lee, Tzung-Yan; Lin, Han-Chieh. Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and N‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. 2014. Hepatology Research. 10.1111/hepr.12379

● (647) Liu, Degui; Wang, Xiaojuan; Yang, Yong; Jiang, Jinheng; Li, Xianhui; Xue, Gang. Effects of hydrogen-rich saline on liver of severely scalded rats with delayed resuscitation. 2014. Chinese Journal of Burns. 10.3760/cma.j.issn.1009-2587.2014.06.010

● (651) Liu, Wei; Dong, Xue-Song; Sun, Yu-Qiang; Liu, Zhi. A novel fluid resuscitation protocol: Provide more protection on acute kidney injury during septic shock in rats. 2014. International Journal of Clinical and Experimental Medicine. 24955162

● (652) Liu, Yantao; Yang, Liqun; Tao, Kunming; Vizcaychipi, Marcela P.; Lloyd, Dafydd M.; Sun, Xuejun; Irwin, Michael G.; Ma, Daqing; Yu, Wei-Feng. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. 2014. BMC Gastroenterology. 10.1186/1471-230X-14-12

● (655) Matsuno, N.; Watanabe, R.; Kimura, M.; Iwata, S.; Fujiyama, M.; Kono, S.; Shigeta, T.; Enosawa, S. Beneficial Effects of Hydrogen Gas on Porcine Liver Reperfusion Injury With Use of Total Vascular Exclusion and Active Venous Bypass. 2014. Transplantation Proceedings. 10.1016/j.transproceed.2013.11.134

● (656) Nakai, Yuji; Sato, Bunpei; Ushiama, Shota; Okada, Shinji; Abe, Keiko; Arai, Soichi. Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. 2014. Bioscience, Biotechnology, and Biochemistry. 10.1271/bbb.100819

● (665) Tan, Yun Chang; Xie, Fang; Zhang, Hui Lu; Zhu, Yu Li; Chen, Ka; Tan, Hua Min; Hu, Ben Shun; Yang, Jia Mei; Tan, Jing Wang. Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. 2014. Gastroenterologie Clinique et Biologique. 10.1016/j.clinre.2013.11.007

● (667) Terawaki, Hiroyuki; Zhu, Wan-Jun; Matsuyama, Yukie; Terada, Tomoyoshi; Takahashi, Yasuhito; Sakurai, Kaoru; Kabayama, Shigeru; Miyazaki, Mariko; Itami, Noritomo; Nakazawa, Ryoichi; Ito, Sadayoshi; Era, Seiichi; Nakayama, Masaaki. Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. 2014. Hemodialysis International. 10.1111/hdi.12112

● (674) Xin, Hai-Guang; Zhang, Bei-Bei; Wu, Zhi-Qin; Hang, Xiao-Feng; Xu, Wen-Sheng; Ni, Wu; Zhang, Rui-Qi; Miao, Xiao-Hui. Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. 2014. Molecular and Cellular Biochemistry. 10.1007/s11010-014-2024-4

● (680) Zeng, K.; Huang, H.; Jiang, X.Q.; Chen, X.J.; Huang, W. Protective effects of hydrogen on renal ischemia/reperfusion injury in rats. 2014. Journal of Sichuan University. 24527579

● (688) Akdeniz, Ekrem; Bostanci, Yakup; Ozden, Ender; Meydan, Bilge Can; Yilmaz, Ali Faik; Sarikaya, Saban; Yakupoglu, Yarkin Kamil. Inhaled Hydrogen Gas Therapy for Prevention of Renal Ischemia/Reperfusion Injury in Rat Model. 2013. Turkiye Klinikleri Journal of Medical Sciences. 10.5336/medsci.2012-32626

● (708) Kawai, Daisuke; Takaki, Akinobu; Yamamoto, Kazuhide. Hydrogen as a treatment candidate for non-alcoholic steatohepatitis. 2013. Journal of Okayama Medical Association. 10.4044/joma.125.201

● (712) Li, Fang-Yin; Zhu, Shao-Xing; Wang, Zong-Ping; Wang, Hua; Zhao, Yang; Chen, Gui-Ping. Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats. 2013. Food and Chemical Toxicology. 10.1016/j.fct.2013.10.004

● (719) Matsumoto, Seiji; Ueda, Tomohiro; Kakizaki, Hidehiro. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. 2013. Urology. 10.1016/j.urology.2012.10.026

● (740) Xia, Chunxiang; Liu, Wenwu; Zeng, Dongxiao; Zhu, Liyao; Sun, Xiaoli; Sun, Xue-Jun. Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. 2013. Clinical and Translational Science. 10.1111/cts.12076

● (742) Xu, Bo; Zhang, Yu-Bo; Li, Zhao-Zhu; Yang, Mo-Wen; Wang, Shuai; Jiang, Da-Peng. Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats. 2013. International Immunopharmacology. 10.1016/j.intimp.2013.06.033

● (743) Xu, X.F.; Zhang, Jin. Saturated Hydrogen Saline Attenuates Endotoxin-Induced Acute Liver Dysfunction in Rats. 2013. Physiological Research. 10.33549/physiolres.932515

● (756) Zhu, Wan-Jun; Nakayama, Masaaki; Mori, Takefumi; Hao, Kiyotaka; Terawaki, Hiroyuki; Katoh, Junichiro; Kabayama, Shigeru; Ito, Sadayoshi. Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. 2013. Medical Gas Research. 10.1186/2045-9912-3-26

● (758) Abe, Toyofumi; Li, Xiao-Kang; Yazawa, Koji; Hatayama, Naoyuki; Xie, Lin; Sato, Bunpei; Kakuta, Yoichi; Tsutahara, Koichi; Okumi, Masayoshi; Tsuda, Hidetoshi; Kaimori, Jun-ya; Isaka, Yoshitaka; Natori, Michiya; Takahara, Shiro; Nonomura, Norio. Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. 2012. Transplantation. 10.1097/TP.0b013e318255f8be

● (776) Katakura, Masanori; Hashimoto, Michio; Tanabe, Yoko; Shido, Osamu. Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. 2012. Medical Gas Research. 10.1186/2045-9912-2-18

● (779) Kawai, Daisuke; Takaki, Akinobu; Nakatsuka, Atsuko; Wada, Jun; Tamaki, Naofumi; Yasunaka, Tatsuya; Koike, Kasuko; Tsuzaki, Ryuichiro; Matsumoto, Kazuyuki; Miyake, Yasuhiro; Shiraha, Hidenori; Morita, Manabu; Makino, Hirofumi; Yamamoto, Kazuhide. Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. 2012. Hepatology. 10.1002/hep.25782

● (804) Tanabe, Hiroki; Sasaki, Yumi; Yamamoto, Tatsuro; Kiriyama, Shuhachi; Nishimura, Naomichi. Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. 2012. Bioscience of Microbiota, Food and Health. 10.12938/bmfh.31.103

● (809) Xiang, Lei; Tan, Jing-Wang; Huang, Li-Jie; Jia, Lin; Liu, Ya-Qian; Zhao, Yu-Qiong; Wang, Kai; Dong, Jia-Hong. Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. 2012. World Journal of Gastroenterology. 10.3748/wjg.v18.i37.5197

● (833) Hashimoto, Michio; Katakura, Masanori; Nabika, Toru; Tanabe, Yoko; Hossain, Shahdat; Tsuchikura, Satoru; Shido, Osamu. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Lepr cp /NDmcr rat - A metabolic syndrome rat model. 2011. Medical Gas Research. 10.1186/2045-9912-1-26

● (859) Matsushita, Taro; Kasukabe, Yoshinori; Kitamura, Akihiro; Okada, Sakie; Murase, Kenya. Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. 2011. Magnetic Resonance in Medical Sciences. 10.2463/mrms.10.169

● (860) Matsushita, Taro; Kusakabe, Yoshinori; Kitamura, Akihiro; Okada, Sakie; Murase, Kenya. Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. 2011. Japanese Journal of Radiology. 10.1007/s11604-011-0588-4

● (863) Nishimura, Naomichi; Tanabe, Hiroki; Sasaki, Yumi; Makita, Yui; Ohata, Misako; Yokoyama, Saori; Asano, Mami; Yamamoto, Tatsuro; Kiriyama, Shuhachi. Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. 2011. British Journal of Nutrition. 10.1017/S0007114511003229

● (871) Sun, Hanyong; Chen, Lei; Zhou, WeiPing; Hu, Liang; Li, Liang; Tu, QianQian; Chang, YanXin; Liu, Qu; Sun, XueJun; Wu, MengChao; Wang, HongYang. The Protective Role of Hydrogen -Rich Saline in Experimental Liver Injury in Mice. 2011. Journal of Hepatology. 10.1016/j.jhep.2010.08.011

● (878) Wang, Fei; Yu, Guang; Liu, Sui-Yi; Li, Jin-Bao; Wang, Jia-Feng; Bo, Lu-Long; Qian, Li-Ren; Sun, Xue-Jun; Deng, Xiao-Ming. Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats. 2011. Journal of Surgical Research. 10.1016/j.jss.2010.11.005

● (883) Yoon, Yang-Suk; Kim, Dong-Heui; Kim, Soo-Ki; Song, Soon-Bong; Uh, Young; Jin, Dan; Qi, Xu-Feng; Teng, Yung-Chien; Lee, Kyu-Jae. The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice. 2011. Food and Chemical Toxicology. 10.1016/j.fct.2011.04.033

● (891) Cardinal, Jon S.; Zhan, Jianghua; Wang, Yinna; Sugimoto, Ryujiro; Tsung, Allan; McCurry, Kenneth R.; Billiar, Timothy R.; Nakao, Atsunori. Oral hydrogen water prevents chronic allograft nephropathy in rats. 2010. Kidney International. 10.1038/ki.2009.421

● (897) Huang, Kuo-Chin; Hsu, Shih-Ping; Yang, Chih-Ching; Ou-Yang, Pu; Lee, Kun-Tai; Morisawa, Shinkatsu; Otsubo, Kazumichi; Chien, Chiang-Ting. Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. 2010. Nephrology, Dialysis, and Transplantation. 10.1093/ndt/gfq082

● (902) Kitamura, A.; Kobayashi, S.; Matsushita, T.; Fujinawa, H.; Murase, Kenya. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. 2010. British Journal of Radiology. 10.1259/bjr/25604811

● (904) Liu, Qu; Shen, Wei-Feng; Sun, Han-Yong; Fan, Dan-Feng; Nakao, Atsunori; Cai, Jian-Mei; Yan, Ge; Zhou, Wei-Ping; Shen, Rong-Xi; Yang, Jia-Mei; Sun, Xue-Jun. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. 2010. Liver International. 10.1111/j.1478-3231.2010.02254.x

● (909) Nakayama, Masaaki; Nakano, Hirofumi; Hamada, Hiromi; Itami, Noritomo; Nakazawa, Ryoichi; Ito, Sadayoshi. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. 2010. Nephrology, Dialysis, and Transplantation. 10.1093/ndt/gfq196

● (917) Shingu, Chihiro; Koga, Hironori; Hagiwara, Satoshi; Matsumoto, Shigekiyo; Goto, Koji; Yokoi, Isao; Noguchi, Takayuki. Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury 2010 Journal of Anesthesia. 10.1007/s00540-010-0942-1

● (928) Zhu, Wan-Jun; Nakayama, Masaaki; Mori, Takefumi; Nakayama, Keisuke; Katoh, Junichiro; Murata, Yaeko; Sato, Toshinobu; Kabayama, Shigeru; Ito, Sadayoshi. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. 2010. Nephrology Dialysis Transplantation. 10.1093/ndt/gfq727

● (929) Abol-Enein, Hassan; Gheith, Osama A.; Barakat, Nashwa; Nour, Eman; Sharaf, Abd-Alhameed. Ionized Alkaline Water: New Strategy for Management of Metabolic Acidosis in Experimental Animals. 2009. Therapeutic Apheresis and Dialysis. 10.1111/j.1744-9987.2009.00659.x

● (934) Kajiya, Mikihito; Sato, Kimihiro; Silva, Marcelo J.B.; Ouhara, Kazuhisa; Do, Phi M.; Shanmugam, K.T.; Kawai, Toshihisa. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. 2009. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2009.06.024

● (942) Nakashima-Kamimura, Naomi; Mori, Takashi; Ohsawa, Ikuroh; Asoh, Sadamitsu; Ohta, Shigeo. Molecular hydrogen alleviates nephrotoxicity induced by anti-cancer drug cisplatin without compromising anti-tumor activity in mice. 2009. Cancer Chemotherapy and Pharmacology. 10.1007/s00280-008-0924-2

● (943) Nakayama, Masaaki; Kabayama, S.; Nakano, H.; Zhu, W.J.; Terawaki, H.; Nakayama, K.; Katoh, K.; Satoh, T.; Ito, Sadayoshi. Biological Effects of Electrolyzed Water in Hemodialysis. 2009. Nephron Clinical Practice. 10.1159/000210569

● (948) Tsai, Chia-Fang; Hsu, Yu-Wen; Chen, Wen-Kang; Chang, Wen-Huei; Yen, Cheng-Chieh; Ho, Yung-Chyuan; Lu, Fung-Jou. Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. 2009. Food and Chemical Toxicology. 10.1016/j.fct.2009.05.021

● (962) Fukuda, Kei-Ichi; Asoh, Sadamitsu; Ishikawa, Masahiro; Yamamoto, Yasuhiro; Ohsawa, Ikuroh; Ohta, Shigeo. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. 2007. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2007.07.088

● (964) Nakayama, Masaaki; Kabayama, Shigeru; Terawaki, Hiroyuki; Nakayama, Keisuke; Kato, Kiyoshi; Sato, Toshinobu; Ito, Sadayoshi. Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. 2007. Hemodialysis International. 10.1111/j.1542-4758.2007.00187.x

● (969) Huang, Kuo-Chin; Yang, C.-C.; Hsu, S.-P.; Lee, K.-T.; Liu, H.-W.; Morisawa, S.; Otsubo, K.; Chien, Chiang-Ting. Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. 2006. Kidney International. 10.1038/sj.ki.5001576

● (985) Huang, Kuo-Chin; Yang, Chih-Ching; Lee, Kun-Tai; Chien, Chiang-Ting. Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. 2003. Kidney International. 10.1046/j.1523-1755.2003.00118.x

● (997) Gharib, B.; Hanna, S.; Abdallahi, O.M.; Lepidi, H.; Gardette, B.; De Reggi, M. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. 2001. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie. 10.1016/s0764-4469(01)01350-6

● (1030) Yano, Satoshi; Wang, Jinyun; Kabayama, Shigeru; Hara, Taichi. Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde Metabolism-Associated Enzymes in the Hepatic Cell Line HepG2. 2021. Antioxidants. 10.3390/antiox10050801

● (1048) Mizutani, Akira; Endo, Amane; Saito, Masahito; Hara, Taichi; Nakagawa, Mayu; Sakuraya, Koji; Murano, Yayoi; Nishizaki, Naoto; Hirano, Daishi; Fujinaga, Shuichiro; Ohtomo, Yoshiyuki; Shimizu, Toshiaki. Hydrogen-rich

water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction. 2021. Pediatric Research. 10.1038/s41390-021-01648-7

● (1075) Sun, Rui; Liu, Xiaocen; Li, Guangshi; Wang, Hui; Luo, Yongxiang; Huang, Guixiao; Wang, Xisheng; Zeng, Guohua; Liu, Zhuang; Wu, Song. A Photo-Activated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer. 2020. ACS Nano. 10.1021/acsnano.0c01300

● (1085) Si, Yachen; Liu, Lulu; Cheng, Jin; Zhao, Tingting; Zhou, Qi; Yu, Jianpeng; Chen, Wei; Ding, Jiarong; Sun, Xuejun; Lu, Hongtao; Gu, Zhiyong. Oral Hydrogen-Rich Water Alleviates Oxalate-Induced Kidney Injury by Suppressing Oxidative Stress, Inflammation, and Fibrosis. 2021. Frontiers in Medicine. 10.3389/fmed.2021.713536

● (1088) Li, Chaofu; Zhao, Xing; Gu, Xiaoqiang; Chen, Ying; Yu, Guanzhen. The Preventive Role of Hydrogen-Rich Water in Thioacetamide-Induced Cholangiofibrosis in Rat Assessed by Automated Histological Classification. 2021. Frontiers in Pharmacology. 10.3389/fphar.2021.632045

● (1135) Wang, Jianwei; Cheng, Quancheng; Fang, Jinyu; Ding, Huiru; Liu, Huaicun; Fang, Xuan; Chen, Chunhua; Zhang, Weiguang. A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl 4-Induced Chronic Liver Injury in Rats. 2021. Antioxidants. 10.3390/antiox10121933

● (1156) Adzavon, Yao Mawulikplimi; Xie, Fei; Yi, Yang; Jiang, Xue; Zhang, Xiaokang; He, Jin; Zhao, Pengxiang; Liu, Mengyu; Ma, Shiwen; Ma, Xuemei. Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways. 2022. Nature Scientific Reports. 10.1038/s41598-022-07710-6

● (1165) Kinoshita, Yoshitaka; Shirakawa, Kohsuke; Sano, Motoaki; Yokoo, Takashi; Kume, Haruki; Kobayashi, Eiji. Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in bilateral kidneys-effects of hydrogen gas inhalation. 2022. Translational Andrology and Urology. 10.21037/tau-21-1164

● (1174) Lu, Hongtao; Ding, Jiarong; Liu, Wenrui; Peng, Zhongjiang; Chen, Wei; Sun, Xuejun; Guo, Zhiyong. UPLC/MS-Based Metabolomics Investigation of the Protective Effect of Hydrogen Gas Inhalation on Mice with Calcium Oxalate-Induced Renal Injury. 2018. Biological and Pharmaceutical Bulletin. 10.1248/bpb.b18-00307