Studies Referencing Hydrogen and Brain, Neurological, Mental Health

Database:

Primary Topic: Brain/Spine

Secondary Topic: Addiction/Alzheimer's Disease (AD)/Amyotrophic Laterial Sclerosis (ALS) /Anxiety/Autism/Brain Injury/Cardiopulmonary Resuscitation (CPR)/Coma/Dementia/Multiple Sclerosis (MS)/Neuropathic Pain/Neuroprotection/Paraplegia/Parkinson's Disease/Seizure/Sleep Deprivation/Spinal Cord Injury (SCI)/Stress Reslience/Stroke/Traumatic Brain Injury/Peripheral Neuropathy, Diabetic (DPN)/ (or Any)

Tertiary Topic: Amyloid Beta Toxicity/Anesthetic Toxicity/Asphyxial Encephalopathy/Cognitive Impairment/Concussion/Deep Hypothermic Circulation Arrest (DHCA)/Depression/Diffuse Axonal Injury (DAI)/Encephalopathy/Excitotoxicity/Intracranial Hemorrhage/Neurodegeneration/Postoperative Cognitive Impairment/Status Epilepticus (SE)/Traumatic Brain Injury (or Any)

 

Neurological Disease

● Coma

• Application of molecular hydrogen has been found to promote recovery from coma (1147: Huang et al 2022).

● Sclerotic Diseases

• Hydrogen has been shown to improve functional recovery and delay disease progression in Amyotrophic Lateral Sclerosis (ALS) (620: Zhang et al 2015) and Multiple Sclerosis (MS) (313: Liu et al 2018; 535: Zhao et al 2016).

● Alzheimer’s Disease and Dementia

• Hydrogen can protect the brain from Amyloid-Beta (Aβ) toxicity (495: Lee, Park, and Park 2016; 562: Lin et al 2015; 291: Hou et al 2018; 903: Li et al 2010; 1047: Lin et al 2022; 257: Zhang et al 2019; 877: Wang et al 2011), and dementia (203: Jiang et al 2019; 324: Nishimaki et al 2018; 159: Bajgal et al 2019).

● Diabetic Peripheral Neuropathy

• Hydrogen has been shown to alleviate Diabetic Peripheral Neuropathy (309: Li et al 2018; 607: Yu et al 2015; 79: Jiao et al 2020).

● Parkinson’s Disease

• Hydrogen offers neuroprotection against the effects of Parkinson’s Disease (PD) (455: Yoshii et al 2017; 718: Matsumoto et al 2013; 39: Zhang et al 2021; 930: Fu et al 2009; 931: Fujita et al 2009; 85: Kobayashi et al 2020; 189: Hirayama et al 2019; 31: Tong et al 2021; 354: Yoritaka et al 2018; 529: Yoritaka et al 2016; 748: Yoritaka et al 2013; 771: Ito et al 2012).

● Seizure

• Hydrogen offers neuroprotection against the damaging effects of seizure (Status Epilepticus) (202: Jia et al 2019).

● Hypoxic and Asphyxial Injuries

• Hydrogen can protect the brain from the damaging effects of asphyxia or other hypoxic events, such as
  • cardiac arrest (523: Wang et al 2016; 193: Huang et al 2019; 293: Huang et al 2018; 164: Chen et al 2019; 371: Chen et al 2017; 701: Huang et al 2013; 632: Hayashida et al 2014; 382: Gao et al 2017; 635: Huo et al 2014; 1162: Li et al 2022)
  • and sleep apnea (311: Li et al 2018), including in neonates (341: Varga et al 2018; 737: Varga et al 2013; 894: Domoki et al 2010; 135: Wang et al 2020; 244: Wu et al 2019; 174: Chu et al 2019; 190: Htun et al 2019; 468: Bai et al 2016; 509: Nemeth et al 2016; 527: Yang, Li, and Chen 2016; 951: Cai et al 2008; 952: Cai et al 2008; 1137: Hu, Wang, and Han 2021).

● Ischemia/Reperfusion Injuries: Stroke and Hemorrhage

• Hydrogen can safely (722: Nagatani et al 2013) protect the brain from the damaging effects of ischemia/reperfusion injuries (549: Han et al 2015; 573: Noda 2015; 624: Cui et al 2014; 721: Nagataniet al 2013; 765: Ge et al 2012; 788: Nagatani et al 2012; 842: Ji et al 2011; 525: Wang et al 2016; 865: Ono et al 2011; 1109: Lee and Choi 2021)
• resulting from hemorrhage (89: Kumagai et al 2020; 583: Shao et al 2015; 849: Lekic et al 2011; 768: Hong et al 2015; 633: Hong et al 2014; 757: Zhuang et al 2013; 817: Zhan et al 2012; 821: Zhuang et al 2012; 162: Camara et al 2019; 669: Tomura et al 2014; 1038: Zhang et al 2021; 155: Zhuang et al 2020; 400: Li and Ai 2017; 1086: Song et al 2021; 1095: Jiang et al 2021)
• and stroke (750: Zhai et al 2013; 422: Ono et al 2017; 790: Ono et al 2012; 78: Jiang et al 2020; 717: Manaenko et al 2013; 858: Manaenko et al 2011; 30: Takeuchi et al 2021; 57: Cong et al 2020; 173: Chen et al 2019; 192: Huang et al 2019; 273: Choi et al 2018; 292: Huang, Liu, and Sun 2018; 322: Ning et al 2018; 349: Wu et al 2018; 472: Cui et al 2016; 498: Li et al 2016; 621: Zhao et al 2015; 785: Li et al 2012; 824: Chen et al 2011; 838: Hugyecz et al 2011; 855: Liu et al 2011; 905: Liu et al 2010; 1076: Wang et al 2021; 589: Takeuchi et al 2015; 1134: An et al 2022).

● Traumatic Injuries

• Hydrogen can protect the brain from the damaging effects of traumatic injuries, such as concussions and blast injuries (569: Ma et al 2015; 653: Ma et al 2014; 471: Chen et al 2016; 625: Dohi et al 2014; 330: Satoh et al 2018; 153: Zhao et al 2020; 283: Fu et al 2018; 594: Tian et al 2015; 609: Yuan et al 2015; 198: Javorac, Stajer, and Ostojic 2019; 137: Wang et al 2020; 346: Wang et al 2018; 355: Yuan et al 2018; 406: Liu et al 2017; 769: Hou et al 2012; 772: Ji et al 2012; 898: Ji et al 2010; 1094: LeBaron, Kharman, and McCullough 2021; 1121: Li et al 2021; 1138: Hu et al 2022),
• including in patients with Diabetes (97: Li et al 2020).
• Hydrogen can alleviate and aid in recovery from spinal cord injuries (270: Chen et al 2018; 596: Wang et al 2014; 648: Liu et al 2014; 892: Chen et al 2010; 384: Ge et al 2017; 837: Huang et al 2011).

● Surgery and Medical Treatment Issues

• Hydrogen can protect the brain from surgery-induced brain injury and cognitive impairment (829: Eckermann et al 2011; 435: Tian et al 2017; 444: Xin et al 2017),
• improve outcomes from surgical procedures (i.e. Cardiopulmonary Bypass (175: Cole et al 2019; 373: Chen et al 2017)
• and Deep Hypothermic Circulatory Arrest (598: Wei et al 2015; 869: Shen et al 2011)),
• and alleviate drug toxicities, including anesthetics (i.e. Isoflurane (399: Li et al 2017) and Sevoflurane (427: Shi et al 2017; 747: Yonamine et al 2013)) and opioid pain-killers (i.e. Remifentanil (683: Zhang et al 2014; 684: Zhang et al 2014)),
• and protect from the damaging effects of hyperoxia (457: Yu et al 2017).

● Sepsis

• Hydrogen is neuroprotective against sepsis-induced encephalopathy (36: Yu et al 2021; 76: Jiang et al 2020; 149: Yu et al 2020; 801: Spulber et al 2012; 819: Zhou et al 2012; 140: Xie et al 2020; 649: Liu et al 2014; 4: Chen et al 2021; 141: Xie et al 2020; 156: Zhuang et al 2020; 650: Liu et al 2014; 74: Jesus et al 2020; 1160: Bai et al 2022).

● Cancer

• Hydrogen has shown efficacy as a cariostatic (168: Chen et al 2019; 215: Liu et al 2019; 229: Qi et al 2019; 353: Yang et al 2018)
• and protects against the harmful effects of radiotherapy (216: Liu et al 2019).

● Environmental Pollution

• Hydrogen can protect the brain from the harmful effects of exposure to environmental pollutants, including
  • carbon monoxide (CO) (233: Shen et al 2019; 739: Wang et al 2013; 807: Wang et al 2012; 873: Sun et al 2011), lead (326: Paulis et al 2018),
  • and pesticides (i.e. Chlorpyrifos (670: Wang et al 2014)
  • and Trimethyltin (154: Zhou et al 2020; 1136: Jeong et al 2021)).

● General Oxidative Stress and Excitotoxicity

• Hydrogen protects the brain from oxidative stress (218: Lu, Liu, and Wang 2019; 977: Kashiwagi et al 2005; 994: Yan et al 2011; 416: Murakami, Ito, and Ohsawa 2017; 920: Ueda, Nakajima, and Oikawa 2010; 960: Sato et al 2008)
• and glutamate-induced excitotoxicity (331: Settineri et al 2018; 638: Kashiwagi et al 2014; 986: Kashiwagi et al 2003).

● Pregnancy-Related Brain Injury

• Hydrogen has been shown to protect against fetal brain injury resulting from maternal hypoxia (854: Liu et al 2011; 654: Mano et al 2014),
• uterine inflammation (488: Imai et al 2016; 571: Nakano et al 2015),
• and material immune activation (296: Imai et al 2018; 1170: Usui et al 2022).

● Neuropathic Pain

• Hydrogen can alleviate neuropathic pain (165: Chen et al 2019; 344: Wang et al 2018; 46: Satoh, Kawaguchi, and Kazama 2015; 541: Chen et al 2015; 628: Ge et al 2014; 640: Kawaguchi et al 2014; 693: Chen et al 2013).

 

Mental Health

● Aging

• Hydrogen can protect the brain from aging-induced cognitive impairment (86: Korovljev et al 2020; 895: Gu et al 2010; 876: Ueda, Kojima, and Oikawa 2011; 638: Kashiwagi et al 2014; 1116: Shinada et al 2021).

● Addiction

• Hydrogen can help protect the brain from the harmful effects of drug addiction, including
  • methamphetamine (138: Wen et al 2020; 242: Wen et al 2019)
  • and morphine (17: Li et al 2021; 440: Wen et al 2017).

● Anxiety, Depression, and Stress Resilience

• Hydrogen has been shown to act as an anxiolytic,
  • reducing anxiety and depression (318: Mizuno et al 2018; 411: Masuda et al 2017; 330: Satoh et al 2018; 534: Zhang et al 2016; 1134: An et al 2022)
  • and increasing resilience to stress (941: Nagata et al 2009; 381: Gao et al 2017).

● Autism

• Hydrogen has been shown to reduce autistic-like social deficit behaviors in the offspring of mice treated with Valproic Acid (287: Guo et al 2018).

● Concentration and Fatigue

• Hydrogen can help improve concentration by attenuating fatigue associated with mental work (1084: Watanabe et al 2018) or sleep deprivation (150: Zanini, Stajer, and Ostojic 2020; 1101: Todorovic et al 2021).

 

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (138: Wen et al 2020; 562: Lin et al 2015; 291: Hou et al 2018; 903: Li et al 2010; 257: Zhang et al 2019; 411: Masuda et al 2017; 721: Nagatani et al 2013; 653: Ma et al 2014; 609: Yuan et al 2015; 573: Noda 2015; 750: Zhai et al 2013; 346: Wang et al 2018; 355: Yuan et al 2018; 769: Hou et al 2012; 772: Ji et al 2012; 898: Ji et al 2010; 216: Liu et al 2019; 701: Huang et al 2013; 765: Ge et al 2012; 788: Nagatani et al 2012; 842: Ji et al 2011; 382: Gao et al 2017; 635: Huo et al 2014; 324: Nishimaki et al 2018; 159: Bajgal et al 2019; 309: Li et al 2018; 607: Yu et al 2015; 97: Li et al 2020; 233: Shen et al 2019; 873: Sun et al 2011; 670: Wang et al 2014; 620: Zhang et al 2015; 534: Zhang et al 2016; 638: Kashiwagi et al 2014; 1084: Watanabe et al 2018; 768: Hong et al 2015; 817: Zhan et al 2012; 821: Zhuang et al 2012; 1038: Zhang et al 2021; 155: Zhuang et al 2020; 509: Nemeth et al 2016; 525: Wang et al 2016; 416: Murakami, Ito, and Ohsawa 2017; 960: Sato et al 2008; 39: Zhang et al 2021; 931: Fujita et al 2009; 149: Yu et al 2020; 819: Zhou et al 2012; 649: Liu et al 2014; 650: Liu et al 2014; 311: Li et al 2018; 785: Li et al 2012; 824: Chen et al 2011; 855: Liu et al 2011; 589: Takeuchi et al 2015; 598: Wei et al 2015; 869: Shen et al 2011; 457: Yu et al 2017; 326: Paulis et al 2018; 640: Kawaguchi et al 2014; 270: Chen et al 2018; 596: Wang et al 2014; 648: Liu et al 2014; 892: Chen et al 2010; 1109: Lee and Choi 2021; 1136: Jeong et al 2021; 1138: Hu et al 2022; 1137: Hu, Wang, and Han 2021),

increasing the activity of endogenous antioxidant enzymes (876: Ueda, Kojima, and Oikawa 2011; 653: Ma et al 2014; 609: Yuan et al 2015; 750: Zhai et al 2013; 346: Wang et al 2018; 355: Yuan et al 2018; 772: Ji et al 2012; 898: Ji et al 2010; 701: Huang et al 2013; 765: Ge et al 2012; 382: Gao et al 2017; 233: Shen et al 2019; 670:Wang et al 2014; 684: Zhang et al 2014; 768: Hong et al 2015; 525: Wang et al 2016; 416: Murakami, Ito, and Ohsawa 2017; 149: Yu et al 2020; 819: Zhou et al 2012; 649: Liu et al 2014; 650: Liu et al 2014; 311: Li et al 2018; 785: Li et al 2012; 869: Shen et al 2011; 326: Paulis et al 2018; 596: Wang et al 2014; 1134: An et al 2022; 1136: Jeong et al 2021; 1138: Hu et al 2022; 1137: Hu, Wang, and Han 2021),

upregulating cellular protection mechanisms (242: Wen et al 2019; 876: Ueda, Kojima, and Oikawa 2011; 495: Lee, Park, and Park 2016; 562: Lin et al 2015; 135: Wang et al 2020; 594: Tian et al 2015; 609: Yuan et al 2015; 137: Wang et al 2020; 346: Wang et al 2018; 355: Yuan et al 2018; 769: Hou et al 2012; 216: Liu et al 2019; 203: Jiang et al 2019; 154: Zhou et al 2020; 313: Liu et al 2018; 331: Settineri et al 2018; 633: Hong et al 2014; 757: Zhuang et al 2013; 1038: Zhang et al 2021; 174: Chu et al 2019; 468: Bai et al 2016; 525: Wang et al 2016; 39: Zhang et al 2021; 149: Yu et al 2020; 801: Spulber et al 2012; 4: Chen et al 2021; 141: Xie et al 2020; 156: Zhuang et al 2020; 650: Liu et al 2014; 74: Jesus et al 2020; 311: Li et al 2018; 57: Cong et al 2020; 165: Chen et al 2019; 344: Wang et al 2018; 596: Wang et al 2014; 1134: An et al 2022; 1136: Jeong et al 2021; 1138: Hu et al 2022; 1137: Hu, Wang, and Han 2021; 1160: Bai et al 2022),

counteracting inflammation and apoptosis (242: Wen et al 2019; 17: Li et al 2021; 876: Ueda, Kojima, and Oikawa 2011; 291: Hou et al 2018; 903: Li et al 2010; 1047: Lin et al 2022; 257: Zhang et al 2019; 877: Wang et al 2011; 287: Guo et al 2018; 341: Varga et al 2018; 569: Ma et al 2015; 625: Dohi et al 2014l 135: Wang et al 2020; 244: Wu et al 2019; 283: Fu et al 2018; 594: Tian et al 2015; 609: Yuan et al 2015; 583: Shao et al 2015; 750: Zhai et al 2013; 842: Ji et al 2011; 635: Huo et al 2014; 203: Jiang et al 2019; 159: Bajgal et al 2019; 309: Li et al 2018; 607: Yu et al 2015; 233: Shen et al 2019; 873: Sun et al 2011; 427: Shi et al 2017; 747: Yonamine et al 2013; 534: Zhang et al 2016; 683: Zhang et al 2014; 381: Gao et al 2017; 768: Hong et al 2015; 633: Hong et al 2014; 757: Zhuang et al 2013; 1038: Zhang et al 2021; 155: Zhuang et al 2020; 174: Chu et al 2019; 527: Yang, Li, and Chen 2016; 951: Cai et al 2008; 952: Cai et al 2008; 400: Li and Ai 2017; 218: Lu, Liu, and Wang 2019; 36: Yu et al 2021; 76: Jiang et al 2020; 149: Yu et al 2020; 801: SpulVber et al 2012; 141: Xie et al 2020; 156: Zhuang et al 2020; 650: Liu et al 2014; 57: Cong et al 2020; 273: Choi et al 2018; 472: Cui et al 2016; 621: Zhao et al 2015; 785: Li et al 2012; 855: Liu et al 2011; 905: Liu et al 2010; ; 373: Chen et al 2017; 869: Shen et al 2011; 435: Tian et al 2017; 444: Xin et al 2017; 165: Chen et al 2019; 541: Chen et al 2015; 628: Ge et al 2014; 693: Chen et al 2013; 270: Chen et al 2018; 596: Wang et al 2014; 648: Liu et al 2014; 892: Chen et al 2010; 384: Ge et al 2017; 1086: Song et al 2021; 1109: Lee and Choi 2021; 1121: Li et al 2021; 1134: An et al 2022; 1136: Jeong et al 2021; 1138: Hu et al 2022; 1137: Hu, Wang, and Han 2021; 1160: Bai et al 2022; 1170: Usui et al 2022),

improving immune function (153: Zhao et al 2020; 89: Kumagai et al 2020; 701: Huang et al 2013; 807: Wang et al 2012; 535: Zhao et al 2016; 498: Li et al 2016),

restoring mitochondrial (562: Lin et al 2015; 1047: Lin et al 2022; 257: Zhang et al 2019; 625: Dohi et al 2014; 283: Fu et al 2018; 624: Cui et al 2014; 620: Zhang et al 2015; 399: Li et al 2017; 977: Kashiwagi et al 2005; 416: Murakami, Ito, and Ohsawa 2017; 140: Xie et al 2020; 141: Xie et al 2020; 173: Chen et al 2019; 349: Wu et al 2018; 457: Yu et al 2017; 79: Jiao et al 2020)

and endoplasmic reticulum (1095: Jiang et al 2021) function, and regulating the gut microbiome (1047: Lin et al 2022).

 

Literature Cited (numbered as per database):

● (4) Chen, Hongguang; Dong, Beibei; Shi, Yuan; Yu, Yonghao; Xie, Ke-Liang. Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the Nrf2 pathway in sepsis-associated encephalopathy. 2021. Neuroscience. 10.1016/j.neuroscience.2021.05.003

● (17) Li, Qing; Zhang, Haifang; Jia, Zhen; Zhang, Linlin; Li, Yize; Xu, Rubin; Wang, Chunyan; Yu, Yonghao. Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS nitration and NMDA receptor trafficking and functioning in the spinal cord of rats. 2021. Neuroscience Letters. 10.1016/j.neulet.2021.135847

● (30) Takeuchi, Satoru; Kumagai, Kosuke; Toyooka, Terushige; Otani, Naoki; Wada, Kojiro; Mori, Kentaro. Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage. 2021. Stroke. 10.1161/STROKEAHA.120.031260

● (31) Tong, Chien-Tai; Hu, Chaur-Jonh; Lin, Hung-Yu; Wu, Daen. Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study. 2021. Medicine. 10.1097/MD.0000000000024191

● (36) Yu, Mingdong; Qin, Chao; Li, Pei; Zhang, Yingli; Wang, Ying; Zhang, Jing; Li, Dedong; Wang, Huixing; Lu, Yuechun; Xie, Keliang; Yu, Yang; Yu, Yonghao. Hydrogen gas alleviates sepsis-induced neuroinflammation and

cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice. 2021. International Immunopharmacology. 10.1016/j.intimp.2021.107583

● (39) Zhang, Zhaoqiang; Sun, Xiao; Wang, Kun; Yu, Yang; Zhang, Li; Zhang, Keping; Gu, Jinglongfei; Yuan, Xiaofan; Song, Guohua. Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in early and medium stages of rotenone-induced Parkinson's disease rats. 2021. Brain Research Bulletin. 10.1016/j.brainresbull.2021.04.003

● (46) Satoh, Yasushi; Kawaguchi, M.; Kazama, T. Abstract: Consumption of hydrogen water prevents the occurrence of neuropathic pain in mice. 2015. Journal of the Neurological Sciences. 10.1016/j.jns.2015.08.1290

● (57) Cong, Hai-Ming; Gao, Qiu-Ping; Song, Guo-Qiang; Ye, Ying-Xin; Li, Xiao-Li; Zhang, Lian-Shuang; Wang, Xi-Feng. Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats. 2020. Iranian Journal of Basic Medical Science. 10.22038/ijbms.2020.41751.9857

● (74) Jesus, Aline A.; Passaglia, Patricia; Santos, Bruna M.; Rodrigues-Santos, Isabelle; Flores, Rafael A.; Batalhao, Marcelo E.; Stabile, Angelita M.; Carnio, Evelin C. Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis. 2020. Brain Research. 10.1016/j.brainres.2020.146857

● (76) Jiang, Yi; Zhang, Kai; Yu, Yang; Wang, Yaoqi; Lian, Naqi; Xie, Keliang; Yu, Yong-Hao. Molecular hydrogen alleviates brain injury and cognitive impairment in a chronic sequelae model of murine polymicrobial sepsis. 2020. Experimental Brain Research. 10.1007/s00221-020-05950-4

● (78) Jiang, Zhao; Alamuri, Tharun T.; Muir, Eric R.; Choi, Dennis W.; Duong, Tim Q. Longitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke in rats. 2020. Brain Research. 10.1016/j.brainres.2020.147122

● (79) Jiao, Yang; Yu, Yang; Li, Bo; Gu, Xiyan; Xie, Keliang; Wang, Guolin; Yu, Yong-Hao. Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats. 2020. Molecular Medicine Reports. 10.3892/mmr.2019.10795

● (85) Kobayashi, Yuki; Imamura, Ryoichi; Koyama, Yoshihisa; Kondo, Makoto; Kobayashi, Hikaru; Nonomura, Norio; Shimada, Shoichi. Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent. 2020. Nature Scientific Reports. 10.1038/s41598-020-62755-9

● (86) Korovljev, Darinka; Trivic, Tatjana; Stajer, Valdemar; Drid, Patrik; Sato, Bunpei; Ostojic, Sergej M. Short-Term H2 Inhalation Improves Cognitive Function in Older Women: A Pilot Study. 2020. International Journal of Gerontology. 10.6890/IJGE.202005_14(2).0013

● (89) Kumagai, Kosuke; Toyooka, Terushige; Takeuchi, Satoru; Otani, Naoki; Wada, Kojiro; Tomiyama, Arata; Mori, Kentaro. Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage. 2020. Nature Scientific Reports. 10.1038/s41598-020-69028-5

● (97) Li, Ting-Ting; Yang, Wan-Chao; Wang, Yue-Zhen; Sun, Tian; Cao, Hong-Ling; Chen, Jian-Feng; Li, Wen-Zhi. Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats. 2020. Brain Research. 10.1016/j.brainres.2020.146651

● (135) Wang, Peipei; Zhao, Mingyi; Chen, Zhiheng; Wu, Guojiao; Fujino, Masayuki; Zhang, Chen; Zhou, Wenjuan; Zhao, Mengwen; Hirano, Shin-ichi; Li, Xiao-Kang; Zhao, Lingling. Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats. 2020. Oxidative Medicine and Cellular Longevity. 10.1155/2020/6978784

● (137) Wang, Yifeng; Wang, Lu; Hu, Tianpeng; Wang, Feng; Han, Zhaoli; Yin, Zhenyu; Ge, Xintong; Xie, Keliang; Lei, Ping. Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury. 2020. Neurological Research. 10.1080/01616412.2020.1747717

● (138) Wen, Di; Hui, Rongji; Liu, Yi; Luo, Yixiao; Wang, Jian; Shen, Xi; Xie, Bing; Yu, Feng; Cong, Bin; Ma, Chunling. Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens. 2020. Progress in Neuropsychopharmacology and Biological Psychiatry. 10.1016/j.pnpbp.2019.109781

● (140) Xie, Ke-Liang; Wang, Yaoqi; Yin, Lijun; Wang, Yuzun; Chen, Hongguang; Mao, Xing; Wang, Guo-Lin. Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice. 2020. Shock. 10.1097/SHK.0000000000001594

● (141) Xie, Ke-Liang; Zhang, Yang; Wang, Yaoqi; Meng, Xiaoyin; Wang, Yuzun; Yu, Yonghao; Chen, Hongguang. Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation. 2020. Inflammation Research. 10.1007/s00011-020-01347-9

● (149) Yu, Yang; Feng, Jingcheng; Lian, Naqi; Yang, Man; Xie, Keliang; Wang, Guolin; Wang, Chunyan; Yu, Yong-Hao. Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway. 2020. International Immunopharmacology. 10.1016/j.intimp.2020.106585

● (150) Zanini, D.; Stajer, V.; Ostojic, Sergej M. Hydrogen vs. Caffeine for Improved Alertness in Sleep-Deprived Humans. 2020. Neurophysiology. 10.1007/s11062-020-09852-7

● (153) Zhao, Qing-Hui; Xie, Fei; Guo, Da-Zhi; Ju, Fang-Di; He, Jin; Yao, Ting-Ting; Zhao, Peng-Xiang; Pan, Shu-Yi; Ma, Xue-Mei. Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury. 2020. Brain Research. 10.1016/j.brainres.2020.147053

● (154) Zhou, Tailai; Zhang, Minghao; Du, Hang; Ablimit, Arzu; Ye, Renyi; Lu, Mingqi; Chang, Xiaojuan; Zhao, Qi; Wang, Yan; Qin, Qizhong. Hydrogen rich water ameliorate Trimethyltin induced spatial learning and memory impairment by regulation of Siah-1. 2020. Research Square. 10.21203/rs.2.23352/v1

● (155) Zhuang, Kai; Zuo, Yu-Chun; Sherchan, Prativa; Wang, Ji-Kai; Yan, Xiao-Xin; Liu, Fei. Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats. 2020. Frontiers in Neuroscience. 10.3389/fnins.2019.01441

● (156) Zhuang, Xinqi; Yu, Yang; Jiang, Yi; Zhao, Sen; Wang, Yuzun; Su, Lin; Xie, Keliang; Yu, Yonghao; Lu, Yuechun; Lv, Guoyi. Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. 2020. International Immunopharmacology. 10.1016/j.intimp.2020.106287

● (159) Bajgai, Johny; Eunsook, Jeong; Kim, Cheol Su; Fadriquela, Ailyn; Kim, Dong-Heui; Lee, Kyu-Jae. Effect of Hydrogen Water Drinking on Dementia Patient through Mechanism of Oxidative Stress and Immune Redox Balance. 2019. Korean Journal of Waters. https://www.earticle.net/Article/A354825

● (162) Camara, Richard; Matei, Nathanael; Camara, Justin; Enkhjargal, Budbazar; Tang, Jiping; Zhang, John H. Hydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage rats: a pilot study. 2019. Medical Gas Research. 10.4103/2045-9912.260648

● (164) Chen, Gang; Li, Jingru; Wang, Jianjie; Chen, Bihua; Li, Yongqin. Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model. 2019. BioMed Research International. 10.1155/2019/6410159

● (165) Chen, Hong-Guang; Zhou, Chunjing; Xie, Keliang; Meng, Xiaoyin; Wang, Yaoqi; Yu, Yong-Hao. Hydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated Inflammasome Inactivation in Neuropathic Pain Rats. 2019. Neuroscience. 10.1016/j.neuroscience.2019.10.046

● (168) Chen, Ji-Bing; Mu, Feng; Lu, Tianyu; Du, Duanming; Xu, Ke-Cheng. Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report. 2019. OncoTargets and Therapy. 10.2147/OTT.S235195

● (173) Chen, Lilin; Chao, Yufan; Cheng, Pengchao; Li, Na; Zheng, Hongnan; Yang, Yajuan. UPLC-QTOF/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic Stroke. 2019. Neurochemical Research. 10.1007/s11064-019-02829-x

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