Studies Referencing Hydrogen and Oxidative Stress and ROS Scavenging

Whole Body - Oxidative Stress – ROS Scavenging

Database:

Primary Topic: Any

Secondary Topic: Inflammation/Lipid Peroxidation/Mitochondrial Function/ROS-Scavenging (or Any)

Tertiary Topic: Autophagy/Coenzyme Q/Hydrogen Safety/Immune Dysfunction/Inflammation/Mitochondrial Function/Oxidative Stress/Redox Potential (or Any)

Note: This document is meant to describe broad-scale attributes of hydrogen which affect the whole body across a range of systems and conditions. For information targeted to specific body systems or conditions, see other documents.

• Hydrogen directly quenches cytotoxic ROS, including
  • OH (hydroxyl radical) (457: Yu et al 2017; 312: Liu et al 2018; 388: Hamasaki et al 2017; 556: Kato, Matsuoka, and Miwa 2015; 965: Ohsawa et al 2007; 90: Kwon, Han, and Park 2020; 47: Asada et al 2020; 623: Chen et al 2014; 177: Djalil et al 2019; 269: Chen et al 2018; 865: Ono et al 2011; 828: Chuai et al 2011; 84: Kiyoi et al 2020; 118: Qiu et al 2020; 467: Abou-Hamdan et al 2016; 487: Igarashi et al 2016; 607: Yu et al 2015; 631: Guo et al 2014; 634: Huang et al 2014; 641: Kikkawa et al 2014; 641: Koyama et al 2014; 673: Xie et al 2014; 814: Yang et al 2012; 871: Sun et al 2011; 875: Terasaki et al 2011; 884: Yu et al 2011; 910: Oharazawa et al 2010; 648: Liu et al 2014; 1056: Wan et al 2020; 1073: Kong et al 2018; 1077: Zhang et al 2019),
  • O2•- (superoxide radical) (312: Liu et al 2018; 553: Hyspler et al 2015; 983: Hiraoka et al 2004; 960: Sato et al 2008; 513: Ren et al 2016; 70: Ishihara et al 2020; 834: Hayashi et al 2011; 323: Nishida et al 2018; 1059: Shirahata et al 1997),
  • ROO· (peroxyl radical) (514: Settineri et al 2016; 443: Xiao and Miwa 2017; 959: Saitoh et al 2008),
  • ClO- (hypochlorite) (312: Liu et al 2018),
  • and ONOO- (peroxynitrite) (312: Liu et al 2018; 965: Ohsawa et al 2007; 832: Hanaoka et al 2011; 284: Fu et al 2018; 585: Shu et al 2015; 604: Yokota et al 2015; 84: Kiyoi et al 2020; 607: Yu et al 2015; 620: Zhang et al 2015; 1056: Wan et al 2020).
• Hydrogen does not quench physiologically important ROS (i.e. signaling oxides), such as
  • H2O2 (hydrogen peroxide) and NO (nitric oxide) (312: Liu et al 2018; 965: Ohsawa et al 2007; 832: Hanaoka et al 2011; 284: Fu et al 2018; 604: Yokota et al 2015).
  • Although hydrogen does not quench signaling oxides directly, it has been shown to compensate for the oxidative stress and damage produced by these molecules (327: Pogorelov, Pogorelova, and Pogorelova 2018; 973: Lee et al 2006; 982: Hanaoka et al 2004; 34: Xiao and Miwa 2021; 1032: Saitoh, Yamaguchi, and Okada 2021; 84: Kiyoi et al 2020; 662: Sakai et al 2014; 698: Guo et al 2013; 713: Li et al 2013; 159: Bajgal et al 2019; 1034: LeBaron, Kharman, and McCullough 2021; 1056: Wan et al 2020; 1058: Penders, Kissner, and Koppenol 2014; 1059: Shirahata et al 1997).
• Hydrogen upregulates cellular protection signaling cascades, including
  • LKB1-AMPK-FoxO1/mTOR (398: Lee et al 2017; 174: Chu et al 2019; 203: Jiang et al 2019; 240: Wang et al 2019),
  • PI3K/PTEN-AKT-mTOR/GSK3β/Foxo3a (39: Zhang et al 2021; 103: Lu et al 2020; 156: Zhuang et al 2020; 94: Li et al 2020; 137: Wang et al 2020; 337: Song et al 2018; 347: Wu et al 2018; 348: Wu et al 2018; 356: Zhang et al 2018; 373: Chen et al 2017; 377: Chen et al 2017; 401: Li et al 2017; 611: Yue et al 2015; 633: Hong et al 2014; 562: Lin et al 2015; 621: Zhao et al 2015),
  • and Keap1-Nrf2-ARE/HO-1/Sirt1 (416: Murakami, Ito, and Ohsawa 2017; 519: Tamaki et al 2016; 462: Zhang et al 2017; 104: Lu et al 2020; 141: Xie et al 2020; 149: Yu et al 2020; 212: Li et al 2019; 249: Yang et al 2019; 255: Yu et al 2019; 313: Liu et al 2018; 355: Yuan et al 2018; 438: Wang and Wang 2017; 459: Yu et al 2017; 473: Diao et al 2016; 538: Chen et al 2015; 605: Yu et al 2015; 709: Kawamura et al 2013; 750: Zhai et al 2013; 4: Chen et al 2021; 48: Begum et al 2020; 61: Fang et al 2020; 96: Li et al 2020; 135: Wang et al 2020; 310: Li et al 2018; 525: Wang et al 2016; 541: Chen et al 2015; 18: Li et al 2021; 430: Sun et al 2017; 445: Xing et al 2017; 487: Igarashi et al 2016; 673: Xie et al 2014; 723: Ning et al 2013; 609: Yuan et al 2015; 426: Shen et al 2017; 692: Chen et al 2013; 578: Qi et al 2015) pathways.
• Hydrogen downregulates inflammatory signaling cascades, including
  • the Ras-ERK1/2-MEK1/2 (695: Chen et al 2013; 138: Wen et al 2020; 904: Liu et al 2010; 614: Zhang et al 2015; 743: Xu and Zhang 2013)
  • and MAPK-AKT-NF-kappa B/NLRP3/HMGB1 (711: Li et al 2013; 48: Begum et al 2020; 366: Zou et al 2018; 583: Shao et al 2015; 661: Ren et al 2014; 23: Nie et al 2021; 146: Yang et al 2020; 167: Chen et al 2019; 135: Wang et al 2020; 652: Liu et al 2014; 923: Xie et al 2010; 786: Liang et al 2012; 481: Han et al 2016; 835: Huang et al 2011; 877: Wang et al 2011; 498: Li et al 2016; 713: Li et al 2013; 787: Liu et al 2012; 816: Yu and Zheng 2012; 818: Zheng and Yu 2012; ; 893: Chen et al 2010; 904: Liu et al 2010; 939: Mao et al 2009; 546: Guo et al 2015; 681: Zhang et al 2014; 794: Qin et al 2012; 110: Nogueira et al 2020; 242: Wen et al 2019; 333: Shi et al 2018; 357: Zhang et al 2018; 435: Tian et al 2017; 515: Shi et al 2016; 540: Chen et al 2015; 547: Guo et al 2015; 584: Shi et al 2015; 613: Zhang et al 2015; 665: Tan et al 2014; 691: Cai et al 2013; 692: Chen et al 2013; 741: Xiao et al 2013; 743: Xu and Zhang 2013; 755: Zhou et al 2013; 870: Song et al 2011; 37: Zhang et al 2021; 400: Li et al 2017; 599: Wu et al 2015; 811: Xie et al 2012) pathways,
  • as well as inflammatory mediators, including Prostaglandin (231: Saramago et al 2019; 346: Wang et al 2018; 356: Zhang et al 2018; 485: Hong et al 2016; 635: Huo et al 2014; 649: Liu et al 2014; 755: Zhou et al 2013; 765: Ge et al 2012; 812: Xie et al 2012; 837: Huang et al 2011; 868: Qu et al 2011),
  • Tumor Necrosis Factor (TNF) (36: Yu et al 2021; 76: Jiang et al 2020; 110: Nogueira et al 2020; 111: Nogueira et al 2020; 129: Tamura et al 2020; 149: Yu et al 2020; 156: Zhuang et al 2020; 159: Bajgal et al 2019; 166: Chen et al 2019; 181: Feng et al 2019; 182: Gao et al 2019; 220: Meng et al 2019; 231: Saramago et al 2019; 235: Tan et al 2019; 242: Wen et al 2019; 255: Yu et al 2019; 264: Ara et al 2018; 268: Chen et al 2018; 273: Choi et al 2018; 279: Fang et al 2018; 283: Fu et al 2018; 287: Guo et al 2018; 295: Iketani et al 2018; 325: Nogueira et al 2018; 333: Shi et al 2018; 337: Song et al 2018; 345: Wang et al 2018; 357: Zhang et al 2018; 358: Zhang et al 2018; 366: Zou et al 2018; 374: Chen et al 2017; 392: Hamasaki et al 2017; 404: Lin et al 2017; 407: Liu et al 2017; 410: Ma et al 2017; 426: Shen et al 2017; 435: Tian et al 2017; 453: Ying et al 2017; 473: Diao et al 2016; 496: Li et al 2016; 497: Li et al 2016; 498: Li et al 2016; 507: Muramatsu et al 2016; 515: Shi et al 2016; 524: Wang et al 2016; 527: Yang, Li, and Chen 2016; 530: Yu et al 2016; 538: Chen et al 2015; 540: Chen et al 2015; 541: Chen et al 2015; 543: Du et al 2015; 545: Guan et al 2015; 547: Guo et al 2015; 548: Haam et al 2015; 554: Ishibashi et al 2015; 566: Liu et al 2015; 568: Luo et al 2015; 583: Shao et al 2015; 584: Shi et al 2015; 594: Tian et al 2015; 600: Wu et al 2015; 613: Zhang et al 2015; 615: Zhang et al 2015; 616: Zhang et al 2015; 617: Zhang et al 2015; 626: Du et al 2014; 627: Du et al 2014; 628: Ge et al 2014; 630: Gu et al 2014; 647: Liu et al 2014; 648: Liu et al 2014; 652: Liu et al 2014; 665: Tan et al 2014; 674: Xin et al 2014; 682: Zhang et al 2014; 683: Zhang et al 2014; 691: Cai et al 2013; 692: Chen et al 2013; 694: Chen et al 2013; 698: Guo et al 2013; 702: Ignacio et al 2013; 703: Ignacio et al 2013; 716: Liu et al 2013; 731: Song et al 2013; 733: Tan et al 2013; 741: Xiao et al 2013; 743: Xu and Zhang 2013; 751: Zhang, Feng, and Chen 2013; 753: Zhao et al 2013; 754: Zhou et al 2013; 755: Zhou et al 2013; 774: Jin et al 2012; 785: Li et al 2012; 786: Liang et al 2012; 801: Spulber et al 2012; 809: Xiang et al 2012; 813: Xu et al 2012; 825: Chen et al 2011; 837: Huang et al 2011; 842: Ji et al 2011; 867: Qiu et al 2011; 869: Shen et al 2011; 870: Song et al 2011; 878: Wang et al 2011; 881: Yang et al 2011; 882: Yoon et al 2011; 886: Zhang et al 2011; 903: Li et al 2010; 905: Liu et al 2010; 918: Sun et al 2010; 933: Kajiya et al 2009; 934: Kajiya et al 2009; 938: Lee et al 2009; 949: Zheng et al 2009; 995: Naito et al 2002; 997: Gharib et al 2001; 635: Huo et al 2014; 811: Xie et al 2012),
  • Interleukin (IL) (37: Zhang et al 2021; 76: Jiang et al 2020; 110: Nogueira et al 2020; 111: Nogueira et al 2020; 156: Zhuang et al 2020; 159: Bajgal et al 2019; 166: Chen et al 2019; 181: Feng et al 2019; 209: Kura et al 2019; 220: Meng et al 2019; 231: Saramago et al 2019; 235: Tan et al 2019; 242: Wen et al 2019; 255: Yu et al 2019; 264: Ara et al 2018; 268: Chen et al 2018; 273: Choi et al 2018; 279: Fang et al 2018; 283: Fu et al 2018; 287: Guo et al 2018; 325: Nogueira et al 2018; 337: Song et al 2018; 345: Wang et al 2018; 358: Zhang et al 2018; 366: Zou et al 2018; 374: Chen et al 2017; 392: Hamasaki et al 2017; 404: Lin et al 2017; 407: Liu et al 2017; 410: Ma et al 2017; 426: Shen et al 2017; 435: Tian et al 2017; 453: Ying et al 2017; 473: Diao et al 2016; 497: Li et al 2016; 507: Muramatsu et al 2016; 524: Wang et al 2016; 527: Yang, Li, and Chen 2016; 530: Yu et al 2016; 538: Chen et al 2015; 541: Chen et al 2015; 543: Du et al 2015; 547: Guo et al 2015; 548: Haam et al 2015; 554: Ishibashi et al 2015; 566: Liu et al 2015; 568: Luo et al 2015; 583: Shao et al 2015; 584: Shi et al 2015; 594: Tian et al 2015; 600: Wu et al 2015; 613: Zhang et al 2015; 616: Zhang et al 2015; 617: Zhang et al 2015; 626: Du et al 2014; 627: Du et al 2014; 628: Ge et al 2014; 630: Gu et al 2014; 636: Ishibashi et al 2014; 647: Liu et al 2014; 648: Liu et al 2014; 652: Liu et al 2014; 665: Tan et al 2014; 674: Xin et al 2014; 682: Zhang et al 2014; 683: Zhang et al 2014; 691: Cai et al 2013; 692: Chen et al 2013; 694: Chen et al 2013; 698: Guo et al 2013; 702: Ignacio et al 2013; 703: Ignacio et al 2013; 716: Liu et al 2013; 733: Tan et al 2013; 741: Xiao et al 2013; 751: Zhang, Feng, and Chen 2013; 753: Zhao et al 2013; 754: Zhou et al 2013; 774: Jin et al 2012; 809: Xiang et al 2012; 842: Ji et al 2011; 867: Qiu et al 2011; 869: Shen et al 2011; 878: Wang et al 2011; 881: Yang et al 2011; 882: Yoon et al 2011; 886: Zhang et al 2011; 903: Li et al 2010; 905: Liu et al 2010; 918: Sun et al 2010; 933: Kajiya et al 2009; 938: Lee et al 2009; ; 949: Zheng et al 2009; 405: Liu et al 2017; 635: Huo et al 2014; 811: Xie et al 2012),
  • and Caspase (20: Lu et al 2021; 48: Begum et al 2020; 68: Imamura et al 2020; 75: Jiang et al 2020; 94: Li et al 2020;  110: Nogueira et al 2020; 118: Qiu et al 2020; 141: Xie et al 2020; 184: Guan et al 2019; 201: Ji, Zheng, and Yao 2019; 202: Jia et al 2019; 203: Jiang et al 2019; 220: Meng et al 2019; 222: Mo et al 2019; 242: Wen et al 2019; 247: Yan et al 2019; 273: Choi et al 2018; 310: Li et al 2018; 337: Song et al 2018; 359: Zhang et al 2018; 373: Chen et al 2017; 378: Dang et al 2017; 382: Gao et al 2017; 385: Golshahi et al 2017; 497: Li et al 2016; 515: Shi et al 2016; 547: Guo et al 2015; 615: Zhang et al 2015; 733: Tan et al 2013; 743: Xu and Zhang 2013; 842: Ji et al 2011; 400: Li et al 2017; 405: Liu et al 2017; 409: Lu et al 2017; 444: Xin et al 2017: 472: Cui et al 2016; 480: Guo et al 2016; 501: Liu et al 2016; 534: Zhang et al 2016; 542: Du et al 2015; 550: Hattori et al 2015; 564: Liu et al 2015; 596: Wang et al 2015; 598: Wei et al 2015; 601: Xiao et al 2015; 745: Yang et al 2013; 756: Zhu et al 2013; 810: Xiao et al 2012; 821: Zhuang et al 2012; 946: Sun et al 2009; 951: Cai et al 2008; 952: Cai et al 2008).
• Hydrogen increases endogenous antioxidant enzyme transcription and activity, including superoxide dismutase, peroxidase, reductase, and catalase (398: Lee et al 2017; 517: Shin et al 2016; 998: Hanaoka 2001; 416: Murakami, Ito, and Ohsawa 2017; 973: Lee et al 2006; 656: Nakai et al 2014; 436: Trivic et al 2017; 50: Cejka et al 2020; 232: Sha et al 2019; 423: Qian et al 2017; 908: Nakao et al 2010; 45: Arima et al 2020; 118: Qiu et al 2020; 142: Xun et al 2020; 375: Chen et al 2017; 379: Dong et al 2017; 487: Igarashi et al 2016; 626: Du et al 2014; 634: Huang et al 2014; 670: Wang et al 2014; 674: Xin et al 2014; 713: Li et al 2013; 716: Liu et al 2013; 768: Hong et al 2012; 772: Ji et al 2012; 787: Liu et al 2012; 816: Yu and Zheng 2012; 818: Zheng and Yu 2012; 867: Qiu et al 2011; 869: Shen et al 2011; 878: Wang et al 2011; 898: Ji et al 2010; 904: Liu et al 2010; 913: Qian et al 2010; 914: Qian et al 2010; 915: Qian et al 2010; 922: Xie et al 2010; 997: Gharib et al 2001; 555: Jing et al 2015; 575: Peng et al 2015; 630: Gu et al 2014; 681: Zhang et al 2014; 744: Yang, Yan, and Ding 2013; 794: Qin et al 2012; 796: Ren et al 2012; 944: Park et al 2009; 948: Tsai et al 2009; 268: Chen et al 2018; 358: Zhang et al 2018; 404: Lin et al 2017; 515: Shi et al 2016; 540: Chen et al 2015; 543: Du et al 2015; 819: Zhou et al 2012).
• Hydrogen also protects against cellular damage by increasing the activity of other endogenous antioxidants such as
  • α-Tocopherol (Vitamin E) (196: Ishida et al 2019; 920: Ueda, Nakajima, and Oikawa 2010),
  • L-ascorbic acid (Vitamin C) (12: Kato, Saitoh, and Miwa 2021; 973: Lee et al 2006; 998: Hanaoka 2001; 920: Ueda, Nakajima, and Oikawa 2010),
  • Coenzyme Q9/10 (63: Gvozdjakova et al 2020; 304: Kucharska et al 2018; 43: Akagi and Baba 2020),
  • Taurine (173: Chen et al 2019),
  • and Glutathione (436: Trivic et al 2017; 443: Xiao and Miwa 2017; 552: Huang, Jiao, and Yan 2015; 575: Peng et al 2015; 609: Yuan et al 2015; 617: Zhang et al 2015; 630: Gu et al 2014; 677: Yoon et al 2014; 681: Zhang et al 2014; 697: Feng et al 2013; 744: Yang, Yan, and Ding 2013; 794: Qin et al 2012; 796: Ren et al 2012; 863: Nishimura et al 2011; 944: Park et al 2009; 947: Tsai et al 2009; 948: Tsai et al 2009; 173: Chen et al 2019; 260: Zhao et al 2019).
• Hydrogen leads to a reduction of bodily cellular oxidation products, indicators of oxidative stress and damage (490: Jeong, Kim, and Lee 2016; 968: Hiraoka et al 2006; 973: Lee et al 2006; 980: Yanagihara et al 2005; 983: Hiraoka et al 2004; 728: Sheng et al 2013; 284: Fu et al 2018; 10: Hu et al 2021; 232: Sha et al 2019; 59: Dobashi, Takeuchi, and Koyama 2020; 423: Qian et al 2017; 623: Chen et al 2014; 908: Nakao et al 2010; 595: Wang et al 2015; 25: Rohovyi et al 2021; 63: Gvozdjakova et al 2020; 118: Qiu et al 2020; 142: Xun et al 2020; 375: Chen et al 2017; 379: Dong et al 2017; 432: Suzuki et al 2017; 626: Du et al 2014; 631: Guo et al 2014; 634: Huang et al 2014; 663: Shigeta et al 2014; 713: Li et al 2013; 716: Liu et al 2013; 721: Nagatani et al 2013; 723: Ning et al 2013; 768: Hong et al 2012; 770: Ishibashi et al 2012; 772: Ji et al 2012; 787: Liu et al 2012; 830: Fang et al 2011; 836: Huang et al 2011; 855: Liu et al 2011; 867: Qiu et al 2011; 868: Qu et al 2011; 869: Shen et al 2011; 872: Sun et al 2011; 875: Terasaki et al 2011; 878: Wang et al 2011; 884: Yu et al 2011; 893: Chen et al 2010; 898: Ji et al 2010; 904: Liu et al 2010; 910: Oharazawa et al 2010; 913: Qian et al 2010; 914: Qian et al 2010; 915: Qian et al 2010; 922: Xie et al 2010; 939: Mao et al 2009; 950: Buchholz et al 2008; 962: Fukuda et al 2007; 997: Gharib et al 2001; 555: Jing et al 2015; 575: Peng et al 2015; 609: Yuan et al 2015; 630: Gu et al 2014; 681: Zhang et al 2014; 794: Qin et al 2012; 796: Ren et al 2012; 654: Mano et al 2014; 209: Kura et al 2019; 358: Zhang et al 2018; 404: Lin et al 2017; 515: Shi et al 2016; 540: Chen et al 2015; 543: Du et al 2015; 635: Huo et al 2014; 799: Shi et al 2012; 819: Zhou et al 2012)
• Hydrogen protects against cellular oxidative damage through the process of hormesis (666: Tanikawa et al 2014; 50: Cejka et al 2020),
• whereby hydrogen acts to activate cellular responses to moderate and severe stress by producing a very mild stress. In Mitochondria specifically, hydrogen acts to increase the mitochondrial membrane potential (i.e. preventing mitochondrial membrane depolarization) and production of ATP (“mitohormesis”) (416: Murakami, Ito, and Ohsawa 2017; 70: Ishihara et al 2020; 63: Gvozdjakova et al 2020; 118: Qiu et al 2020; 816: Yu and Zheng 2012; 818: Zheng and Yu 2012; 399: Li et al 2017).
• Hydrogen leads to more negative saliva ORP (Oxidation-Reduction Potential) (130: Tanaka et al 2020)
• and a higher bodily BAP (Biological Antioxidant Potential) (10: Hu et al 2021; 232: Sha et al 2019; 59: Dobashi, Takeuchi, and Koyama 2020; 1: Alharbi et al 2021; 833: Hashimoto et al 2011; 1123: Tanaka, Xiao, and Miwa 2021)

Literature Cited (numbered as per database):

• (1) Alharbi, Ahad Abdulkarim D.; Ebine, Naoyuki; Nakae, Satoshi; Hojo, Tatsuya; Fukuoka, Yoshiyuki. Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans. 2021. Nutrients. 10.3390/nu13020459
• (4) Chen, Hongguang; Dong, Beibei; Shi, Yuan; Yu, Yonghao; Xie, Ke-Liang. Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the Nrf2 pathway in sepsis-associated encephalopathy. 2021. Neuroscience. 10.1016/j.neuroscience.2021.05.003

• (10) Hu, Di; Li, Danxi; Shigeta, Mika; Ochi, Yuta; Okauchi, Takashi; Neyama, Hiroyuki; Kabayama, Shigeru; Watanabe, Yasuyoshi; Cui, Yilong. Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water. 2021. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2020.12.035
• (12) Kato, Shinya; Saitoh, Yasukazu; Miwa, Nobuhiko. Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen. 2021. Human Cell. 10.1007/s13577-020-00462-3
• (18) Li, Shao-Wei; Takahara, Terumi; Que, Weitao; Fujino, Masayuki; Guo, Wen-Zhi; Hirano, Shin-Ichi; Ye, Li-Ping; Li, Xiao-Kang. Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling. 2021. American Journal of Physiology: Gastrointestinal and Liver Physiology. 10.1152/ajpgi.00158.2020
• (20) Lu, Hongwei; Wang, Wei; Kang, Xiaodiao; Lin, Zeng; Pan, Jun; Cheng, Shaowen; Zhang, Jingdong. Hydrogen (H 2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway. 2021. Journal of Inflammation Research. 10.2147/JIR.S297622
• (23) Nie, Chaoqun; Ding, Xue; A, Rong; Zheng, Min; Li, Zhenning; Pan, Shuang; Yang, Wei. Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats. 2021. Life Sciences. 10.1016/j.lfs.2021.119248
• (25) Rohovyi, Yu.; Tsitrin, V.; Arkchipova, L.; Bilookyi, V.; Kolesnik, O. THE USE OF MOLECULAR HYDROGEN IN CORRECTION OF NO-REFLOW SYNDROME IN THE POLYURIC STAGE OF SUBLIMATE NEPHROPATHY. 2021. Georgian Medical News. 33814411
• (34) Xiao, Li; Miwa, Nobuhiko. Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. 2021. Cells. 10.3390/cells10030626
• (36) Yu, Mingdong; Qin, Chao; Li, Pei; Zhang, Yingli; Wang, Ying; Zhang, Jing; Li, Dedong; Wang, Huixing; Lu, Yuechun; Xie, Keliang; Yu, Yang; Yu, Yonghao. Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice. 2021. International Immunopharmacology. 10.1016/j.intimp.2021.107583
• (37) Zhang, Jingxi; Feng, Xiumin; Fan, Yunxin; Zhu, Guanglin; Bai, Chong. Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis. 2021. Inflammation Research. 10.1007/s00011-021-01459-w
• (39) Zhang, Zhaoqiang; Sun, Xiao; Wang, Kun; Yu, Yang; Zhang, Li; Zhang, Keping; Gu, Jinglongfei; Yuan, Xiaofan; Song, Guohua. Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in early and medium stages of rotenone-induced Parkinson's disease rats. 2021. Brain Research Bulletin. 10.1016/j.brainresbull.2021.04.003
• (43) Akagi, Junji; Baba, Hideo. Hydrogen gas activates coenzyme Q10 to restore exhausted CD8 + T cells, especially PD-1 + Tim3 + terminal CD8 + T cells, leading to better nivolumab outcomes in patients with lung cancer. 2020 Oncology Letters. 10.3892/ol.2020.12121
• (45) Arima, Takeshi; Igarashi, Tsutomu; Uchiyama, Masaaki; Kobayashi, Maika; Ohsawa, Ikuroh; Shimizu, Akira; Takahashi, Hiroshi. Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model. 2020. International Journal of Ophthalmology. 10.18240/ijo.2020.08.01
• (47) Asada, Ryoko; Tazawa, Kenji; Sato, Shinkichi; Miwa, Nobuhiko. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. 2020. Medical Gas Research. 10.4103/2045-9912.296041
• (48) Begum, Rahima; Kim, Cheol-Su; Fadriquela, Ailyn; Bajgai, Johny; Jing, Xingyu; Kim, Dong-Heui; Kim, Soo-Ki; Lee, Kyu-Jae. Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway. 2020. Molecular and Cellular Toxicology. 10.1007/s13273-020-00074-w
• (50) Cejka, Cestmir; Kossl, Jan; Holan, Vladimir; Zhang, John H.; Cejkova, Jitka. An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress. 2020. Oxidative Medicine and Cellular Longevity. 10.1155/2020/7435260
• (59) Dobashi, Shohei; Takeuchi, Kaito; Koyama, Katsuhiro. Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males. 2020. Medical Gas Research. 10.4103/2045-9912.279979
• (61) Fang, Wei; Tang, Luyan; Wang, Guizhen; Lin, Jinran; Liao, Wanqing; Pan, Weihua; Xu, Jinhua. Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling. 2020. Journal of Investigative Dermatology. 10.1016/j.jid.2019.03.1165
• (63) Gvozdjakova, Anna; Kucharska, Jarmila; Kura, Branislav; Vancova, Olga; Rausova, Zuzana; Sumbalova, Zuzana; Ulicna, Olga; Slezak, Jan. A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats. 2020. Canadian Journal of Physiology and Pharmacology. 10.1139/cjpp-2019-0281
• (68) Imamura, Ryoichi; Kawamura, Masataka; Taniguchi, Ayumu; Kobayashi, Yuki; Nakazawa, Shigeaki; Kato, Taigo; Abe, Toyofumi; Uemura, Motohide; Kobayashi, Hikaru; Nonomura, Norio. Efficacy of a Si-based agent against developing renal failure in a rat remnant kidney model. 2020. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2020.10.067
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