Studies Referencing Hydrogen and Surgery, Transplantation, Medical Care

Database:

Primary Topic: Any

Secondary Topic: Cardiopulmonary Resuscitation (CPR)/Haemodialysis/Peritoneal Dialysis/Sepsis/Shock/(Surgery/Transplantation)/Wound Healing (or Any)

Tertiary Topic: Balloon Injury/Biocompatibility/Burn/Cardiopulmonary Bypass (CPB)/Contrast Media Toxicity (Loversol)/Deep Hypothermic Circulation Arrest (DHCA)/Drug Toxicity/Graft-Versus-Hose-Disease (GVHD)/Hemorrhagic Shock/Hyperoxia/Hypoxic Post-Conditioning)/Ischemia-Reperfusion (I/R) Injury/Multiple Organ Dysfunction Syndrome (MODS)/Novel Therapy/One-Lung Ventilation (OLV)/Osteochondral Allograft/Pathogenic Bacterial Load/Peripheral Nerve Autographting/Postoperative Cognitive Impairment/Postoperative Ileus (POI)/Postoperative Liver Failure/Postsurgical Peritoneal Adhesions (PPA)/Pressure Ulcer/Primary Graft Dysfunction (PGD)/Steroid Toxicity/Vein Graft/Ventilator-Induced Lung Injury (VILI)/Wound Healing (or Any)

 

Note: For information regarding cancer and cancer treatment, see the Cancer – Chemotherapy document.

 

Surgery/Transplantation

● One of the earliest known uses of hydrogen gas is as an intestinal insufflant used in the diagnosis of gastrointestinal pathologies (1026: Pilcher 1888).

Bone/Joint

• Hydrogen has been shown reduce pain and swelling, improve range of motion, and aid in healing of ankle (72: Javorac et al 2020; 73: Javorac, Stajer, and Ostojic 2020) and toe (1081: Tarnava 2021) sprain.
• Hydrogen has been shown to reduce swelling and improve range of motion after soft tissue injury (659: Ostojic, Stojanovic, and Hoffman 2014; 660: Ostojic et al 2014).
  • Additionally, hydrogen has shown promise in tendon repair, as it can reduce tendon adhesion and inflammation (317: Meng et al 2018).
• Hydrogen has been shown to enhance bone regeneration after fracture (225: Ozawa et al 2019; 44: Antoniac et al 2020; 1072: Zhao et al 2018),
  • inhibit osteoclastogenesis (101: Liu et al 2020; 711: Li et al 2013; 243: Wu et al 2019; 732: Sun et al 2013),
  • protect chrondrocytes from oxidative stress (832: Hanaoka et al 2011),
  • and enhance mineralization rate and osteogenesis (3: Carnovali, Mariotti, and Banfi 2021).

Transplantation and Graft Dysfunctions

o Hydrogen has been shown to effectively prevent and treat Graft-Versus-Host-Disease and other morbidities resulting from the transplantation of bone marrow/hematopoietic stem cells (511: Qian and Shen 2016; 424: Qian et al 2017; 727: Qian et al 2013; 114: Qian et al 2020; 610: Yuan et al 2015; 1114: Qian et al 2021),

• heart tissue (733: Tan et al 2013; 918: Sun et al 2010; 1006: Ogino et al 2000; 725: Noda et al 2013; 789: Noda et al 2012; 907: Nakao et al 2010),
• blood vessels (802: Sun et al 2012),
• intestinal tissue (145: Yamamoto et al 2020; 663: Shigeta et al 2014; 823: Buchholz et al 2011; 950: Buchholz et al 2008),
• osteochondral tissue (186: Han et al 2019; 676: Yamada et al 2014),
• kidney tissue (891: Cardinal et al 2010; 206: Kobayashi and Sano 2019; 758: Abe et al 2012; 82: Kawamura et al 2020; 24: Nishi et al 2021),
• nerve tissue (619: Zhang et al 2015), liver tissue (239: Uto et al 2019; 297: Ishikawa et al 2018; 339: Tamaki et al 2018; 516: Shimada et al 2016; 655: Matsuno et al 2014),
• lung tissue (113: Ozeki et al 2020; 83: Kayawake et al 2020; 230: Saito et al 2019; 357: Zhang et al 2018; 504: Meng et al 2016; 566: Liu et al 2015; 754: Zhou et al 2013; 805: Tanaka et al 2012; 900: Kawamura et al 2010; 288: Haam et al 2018; 548: Haam et al 2015; 657: Noda et al 2014; 846: Kawamura et al 2011; 1091: Zheng etal 2021; 1131: Zhang et al 2019; 1132: Saito et al 2018),
• and pancreatic tissue (568: Luo et al 2015; 1009: Miyamoto et al 1999).

Heart and Cardiovascular System

o Hydrogen constrains inflammation associated with Cardiopulmonary Bypass (CPB) (763: Fujii et al 2012; 175: Cole et al 2019; 373: Chen et al 2017; 268: Chen et al 2018; 337: Song et al 2018; 1084: Danilova et al 2021) and Angioplasty (794: Qin et al 2012; 695: Chen et al 2013; 396: Katsumata et al 2017).

o Hydrogen has been shown to improve the outcome of Deep Hypothermic Circulation Arrest (DHCA) (598: Wei et al 2015; 869: Shen et al 2011).

Intestinal Surgery

o Hydrogen has been shown to improve the outcome of surgical reduction of intestinal volvulus (1161: Oral et al 2022).

Stem Cells

o Hydrogen can prevent senescence and increase the replicative lifespan of stem cells (901: Kawasaki, Guan, and Tamama 2017).

Hyperbaric Oxygenation and Ventilator Injury

o Hydrogen has been shown to relieve lung tissue injuries resulting from ventilator use (600: Wu et al 2015; 835: Huang et al 2011; 896: Huang et al 2010; 1042: Huang et al 2010).

o Hydrogen has been shown to alleviate tissue injuries resulting from hyperoxia (836: Huang et al 2011; 347: Wu et al 2018; 430: Sun et al 2017; 746: Yao et al 2013; 872: Sun et al 2011; 927: Zheng et al 2010; 315: Lu et al 2018; 709: Kawamura et al 2013; 457: Yu et al 2017).

Skin and Cosmetic Surgeries

o Hydrogen has been shown to improve the outcomes of skin and cosmetic surgeries (121: Sahin et al 2020; 178: Dong et al 2019; 567: Liu et al 2015; 601: Xiao et al 2015; 752: Zhao et al 2013; 1157: Otani et al 2022),

• including penile surgery (8: Gulburun et al 2021).

Medication Efficacy

o Hydrogen has been shown to increase skin permeability to Lidocaine and Isosorbide Mononitrate (936: Kitamura et al 2009).

Postoperative Care

o Hydrogen protects the organs from inflammation and morbidity associated with surgery and other medical procedures, including specifically

• the brain (175: Cole et al 2019; 373: Chen et al 2017; 635: Huo et al 2014; 382: Gao et al 2017; 435: Tian et al 2017; 444: Xin et al 2017; 829: Eckermann et al 2011),
• kidneys (175: Cole et al 2019; 542: Du et al 2015),
• intestine (510: Okamoto et al 2016; 179: Eryilmaz et al 2019), liver (376: Chen et al 2017; 665: Tan et al 2014; 1117: Kaibori and Kosaka 2021),
• eyes (195: Igarashi et al 2019; 487: Igarashi et al 2016; 679: You et al 2014),
• blood (423: Qian et al 2017), and peritonium (407: Liu et al 2017).

o Hydrogen has been shown to improve wound healing (519: Tamaki et al 2016; 547: Guo et al 2015; 911: Okajima, Shimokawa, and Ishii 2010; 120: Safonov et al 2020; 248: Yang et al 2019; 764: Ge et al 2012; 714: Li et al 2013; 254: Yu et al 2019; 308: Li, Tanaka, and Miwa 2018; 329: Salisbury and Percival 2018; 544: Gojoubori et al 2015; 629: Gojoubori et al 2014; 991: Xin et al 2003; 1004: Nakae and Inaba 2000; 1005: Nakae and Inaba 2000; 60: Fadriquela et al 2020; 456: You et al 2017; 1007: Yahagi et al 2000; 857: Makino et al 2011; 1019: Sekiya et al 1997; 679: You et al 2014; 606: Yu et al 2015; 1097: Zan et al 2021; 1127: Qi et al 2021; 1163: Li et al 2022).

o Hypoxic Post-Conditioning can be improved with hydrogen (460: Zalesak et al 2017; 614: Zhang et al 2015; 615: Zhang et al 2015).

 

Ischemia/Reperfusion and Hypoxic Injuries

● Hydrogen has been shown to relieve ischemia/reperfusion injuries resulting from intermittent tissue hypoxia (175: Cole et al 2019; 373: Chen et al 2017; 635: Huo et al 2014; 382: Gao et al 2017; 32: Tong et al 2021; 366: Zou et al 2018; 439: Watanabe et al 2017; 595: Wang et al 2015; 634: Huang et al 2014),

• including specifically the heart (23: Nie et al 2021; 611: Yue et al 2015; 673: Xie et al 2014; 730: Shinbo et al 2013; 733: Tan et al 2013; 886: Zhang et al 2011; 907: Nakao et al 2010; 946: Sun et al 2009; 460: Zalesak et al 2017; 614: Zhang et al 2015; 615: Zhang et al 2015; 1171: Gong et al 2022),
• lungs (799: Shi et al 2012),
• intestine (145: Yamamoto et al 2020; 179: Eryilmaz et al 2019; 252: Yao et al 2019; 442: Wu et al 2017; 663: Shigeta et al 2014; 826: Chen et al 2011; 949: Zheng et al 2009; 950: Buchholz et al 2008; 1161: Oral et al 2022),
• kidneys (323: Nishida et al 2018; 680: Zeng et al 2014; 688: Akdeniz et al 2013; 758: Abe et al 2012; 878: Wang et al 2011; 917: Shingu et al 2010; 82: Kawamura et al 2020; 1165: Kinoshita et al 2022),
• liver (239: Uto et al 2019; 258: Zhang et al 2019; 266: Bai et al 2018; 285: Ge et al 2018; 297: Ishikawa et al 2018; 307: Li et al 2018; 359: Zhang et al 2018; 385: Golshahi et al 2017; 401: Li et al 2017; 516: Shimada et al 2016; 605: Yu et al 2015; 613: Zhang et al 2015; 652: Liu et al 2014; 804: Tanabe et al 2012; 809: Xiang et al 2012; 863: Nishimura et al 2011; 962: Fukuda et al 2007; 219: Maly et al 2019; 151: Zhang et al 2020),
• lungs (357: Zhang et al 2018; 433: Takahashi et al 2017; 504: Meng et al 2016; 754: Zhou et al 2013; 784: Li et al 2012; 900: Kawamura et al 2010), pancreas (568: Luo et al 2015),
• skin (178: Dong et al 2019; 567: Liu et al 2015; 601: Xiao et al 2015; 752: Zhao et al 2013; 1157: Otani et al 2022), spine (755: Zhou et al 2013; 1027: Kimura et al 2021),
• and brain (598: Wei et al 2015).

Sepsis

● Hydrogen has been shown to protect the organs from inflammation and morbidity caused by sepsis (22: Matsuura et al 2021; 231: Saramago et al 2019; 921: Xie et al 2010; 99: Yu and Yu 2016; 167: Chen et al 2019; 713: Li et al 2013; 922: Xie et al 2010; 923: Xie et al 2010; 1149: Shirakawa et al 2022),

• including specifically the brain (36: Yu et al 2021; 76: Jiang et al 2020; 149: Yu et al 2020; 819: Zhou et al 2012; 140: Xie et al 2020; 649: Liu et al 2014; 4: Chen et al 2021; 141: Xie et al 2020; 156: Zhuang et al 2020; 650: Liu et al 2014; 74: Jesus et al 2020; 801: Spulber et al 2012; 1160: Bai et al 2022),
• heart (152: Zhang et al 2020; 235: Tan et al 2019; 592: Tao et al 2015),
• lungs (1054: Qiu et al 2021; 249: Yang et al 2019; 521: Tao et al 2016; 255: Yu et al 2019; 276: Dong et al 2018; 500: Liu et al 2016; 612: Zhai et al 2015; 618: Zhang, Liu, and Zhang 2015; 716: Liu et al 2013; 811: Xie et al 2012; 1035: Chen et al 2021; 1041: Bian et al 2016; 530: Yu et al 2016; 166: Chen et al 2019; 392: Hong et al 2017; 485: Hong et al 2016; 561: Li et al 2015; 812: Xie et al 2012; 1108: Du et al 2021; 1151: Li et al 2020; 1154: Fu et al 2020; 1155: Bian et al 2018; 1141: Fan et al 2022; 1167: Shi et al 2022),
• kidneys (253: Yao et al 2019; 651: Liu et al 2014; 166: Chen et al 2019; 392: Hong et al 2017; 485: Hong et al 2016; 812: Xie et al 2012),
• liver (394: Iketani et al 2017; 743: Xu and Zhang 2013; 262: Zhu et al 2019; 247: Yan et al 2019; 166: Chen et al 2019; 392: Hong et al 2017; 485: Hong et al 2016; 812: Xie et al 2012),
• endothelium (538: Chen et al 2015; 738: Wang et al 2013; 602: Xie et al 2015; 608: Yu et al 2015),
• peritoneum (26: Sada et al 2021; 681: Zhang et al 2014; 937: Kubota et al 2009; 1017: Inoue et al 1997),
• and intestine (294: Ikeda et al 2018; 148: Yin et al 2020; 459: Yu et al 2017; 616: Zhang et al 2015; 1043: Ma et al 2016; 77: Jiang et al 2020; 528: Yang et al 2016; 560: Li et al 2015; 716: Liu et al 2013).

Critical Care Medicine

● Hydrogen has been shown to protect the organs from inflammation and morbidity caused by hemorrhagic (122: Sato et al 2020; 129: Tamura et al 2020; 414: Matsuoka et al 2017; 627: Du et al 2014) and burn-induced (597: Wang et al 2015) shock, including specifically

• • the lungs (220: Meng et al 2019; 223: Moon et al 2019; 830: Fang et al 2011; 558: Kohama et al 2015; 626: Du et al 2014; 1150: Qin et al 2017),
  • liver (378: Dang et al 2017; 647: Liu et al 2014),
  • kidneys (345: Wang et al 2018; 546: Guo et al 2015),
  • and intestine (543: Du et al 2015; 774: Jin et al 2012).

● Hydrogen has been shown to improve outcomes of Cardiopulmonary Resuscitation (CPR) (635: Huo et al 2014; 382: Gao et al 2017; 523: Wang et al 2016; 193: Huang et al 2019; 293: Huang et al 2018; 164: Chen et al 2019; 371: Chen et al 2017; 632: Hayashida et al 2014; 767: Hayashida et al 2012)

• and Extracorporeal Cardiopulmonary Resuscitation (ECPR) (1129: Yin et al 2021).

Dialysis

● Hydrogen has been shown to be a safe addition to haemodialysis (964: Nakayama et al 2007; 320: Nakayama et al 2018) and peritonial dialysis (321: Nakayama et al 2018; 419: Nakayama et al 2017; 593: Terawaki et al 2015) solutions in order to

• reduce inflammation and oxidative stress (943: Nakayama et al 2009; 969: Huang et al 2006; 502: Maeda et al 2016; 909: Nakayama et al 2010; 985: Huang et al 2003; 667: Terawaki et al 2014; 103: Lu et al 2020; 734: Terawaki et al 2013)
• and immune dysfunction (897: Huang et al 2010),
• improve blood pressure (943: Nakayama et al 2009; 418: Nakayama et al 2017; 909: Nakayama et al 2010),
• and increase detoxification and clearance (591: Tange, Takesawa, and Yoshitake 2015).

Drug Toxicities

● Hydrogen can protect against the deleterious side effects of certain medications, including

• immunosuppressants (i.e. Cyclosporine A (104: Lu et al 2010)),
• antidiabetics (i.e. Metformin (1115: Zhao et al 2021)),
• anesthetics (i.e. Remifantanil (), Isoflurane (399: Li et al 2017),
• and Sevoflurane (427: Shi et al 2017; 747: Yonamine et al 2013)),
• antibiotics (i.e. Gentamicin (859: Matsushita et al 2011)),
• antipsychotics (i.e. Valproic Acid (287: Guo et al 2018)),
• contrast media (i.e. Loversol (551: Homma et al 2015)),
• cardiac stimulants (i.e. Isoproterenol (464: Zhang et al 2017; 533: Zhang et al 2016; 555: Jing et al 2015)),
• corticosteroids (i.e. Prednisolone (402: Li et al 2017; 552: Huang et al 2015)),
• opioid pain-relievers (i.e. Morphine (17: Li et al 2021; 440: Wen et al 2017)
• and Remifentanil (585: Shu et al 2015; 683: Zhang et al 2014; 684: Zhang et al 2014)),
• and OTC pain-relievers (i.e. Acetaminophen (617: Zhang et al 2015)
• and Aspirin (682: Zhang et al 2014; 995: Naito et al 2002; 675: Xue et al 2014)).

Mode of Action

Hydrogen shows multiple modes of action, including

• quenching cellular ROS (635: Huo et al 2014; 382: Gao et al 2017; 969: Huang et al 2006; 985: Huang et al 2003; 667: Terawaki et al 2014; 103: Lu et al 2020; 734: Terawaki et al 2013; 819: Zhou et al 2012; 294: Ikeda et al 2018; 649: Liu et al 2014; 650: Liu et al 2014; 459: Yu et al 2017; 560: Li et al 2015; 743: Xu and Zhang 2013; 249: Yang et al 2019; 255: Yu et al 2019; 612: Zhai et al 2015; 618: Zhang, Liu, and Zhang 2015; 716: Liu et al 2013; 26: Sada et al 2021; 681: Zhang et al 2014; 530: Yu et al 2016; 485: Hong et al 2016; 713: Li et al 2013; 922: Xie et al 2010; 923: Xie et al 2010; 543: Du et al 2015; 378: Dang et al 2017; 220: Meng et al 2019; 627: Du et al 2014; 794: Qin et al 2012; 23: Nie et al 2021; 337: Song et al 2018; 673: Xie et al 2014; 733: Tan et al 2013; 799: Shi et al 2012; 907: Nakao et al 2010; 946: Sun et al 2009; 918: Sun et al 2010; 442: Wu et al 2017; 663: Shigeta et al 2014; 826: Chen et al 2011; 104: Lu et al 2010; 323: Nishida et al 2018; 542: Du et al 2015; 758: Abe et al 2012; 878: Wang et al 2011; 917: Shingu et al 2010; 366: Zou et al 2018; 239: Uto et al 2019; 385: Golshahi et al 2017; 962: Fukuda et al 2007; 665: Tan et al 2014; 566: Liu et al 2015; 754: Zhou et al 2013; 634: Huang et al 2014; 121: Sahin et al 2020; 585: Shu et al 2015; 755: Zhou et al 2013; 407: Liu et al 2017; 519: Tamaki et al 2016; 774: Jin et al 2012; 546: Guo et al 2015; 830: Fang et al 2011; 551: Homma et al 2015; 869: Shen et al 2011; 555: Jing et al 2015; 626: Du et al 2014; 836: Huang et al 2011; 746: Yao et al 2013; 872: Sun et al 2011; 457: Yu et al 2017; 317: Meng et al 2018; 767: Hayashida et al 2012; 1108: Du et al 2021; 1131: Zhang et al 2019; 1161: Oral et al 2022),
• increasing the activity of endogenous antioxidant enzymes (635: Huo et al 2014; 382: Gao et al 2017; 985: Huang et al 2003; 819: Zhou et al 2012; 649: Liu et al 2014; 650: Liu et al 2014; 249: Yang et al 2019; 255: Yu et al 2019; 612: Zhai et al 2015; 716: Liu et al 2013; 681: Zhang et al 2014;530: Yu et al 2016; 485: Hong et al 2016; 713: Li et al 2013; 812: Xie et al 2012; 922: Xie et al 2010; 923: Xie et al 2010; 543: Du et al 2015; 220: Meng et al 2019; 627: Du et al 2014; 794: Qin et al 2012; 337: Song et al 2018; 733: Tan et al 2013; 918: Sun et al 2010; 442: Wu et al 2017; 104: Lu et al 2010; 878: Wang et al 2011; 366: Zou et al 2018; 385: Golshahi et al 2017; 665: Tan et al 2014; 566: Liu et al 2015; 754: Zhou et al 2013; 784: Li et al 2012; 288: Haam et al 2018; 568: Luo et al 2015; 755: Zhou et al 2013; 519: Tamaki et al 2016; 774: Jin et al 2012; 546: Guo et al 2015; 869: Shen et al 2011; 617: Zhang et al 2015; 682: Zhang et al 2014; 626: Du et al 2014; 746: Yao et al 2013; 317: Meng et al 2018; 1108: Du et al 2021; 1127: Qi et al 2021; 1150: Qin et al 2017),
• upregulating cellular protection mechanisms (382: Gao et al 2017; 897: Huang et al 2010; 74: Jesus et al 2020; 148: Yin et al 2020; 560: Li et al 2015; 394: Iketani et al 2017; 743: Xu and Zhang 2013; 247: Yan et al 2019; 255: Yu et al 2019; 1035: Chen et al 2021; 231: Saramago et al 2019; 812: Xie et al 2012; 543: Du et al 2015; 673: Xie et al 2014; 252: Yao et al 2019 239: Uto et al 2019; 605: Yu et al 2015; 613: Zhang et al 2015; 805: Tanaka et al 2012; 835: Huang et al 2011; 896: Huang et al 2010; 567: Liu et al 2015; 601: Xiao et al 2015; 519: Tamaki et al 2016; 801: Spulber et al 2012; 347: Wu et al 2018; 315: Lu et al 2018; 709: Kawamura et al 2013; 1108: Du et al 2021; 1129: Yin et al 2021; 1127: Qi et al 2021; 1160: Bai et al 2022; 1151: Li et al 2020; 1155: Bian et al 2018; 1163: Li et al 2022; 1167: Shi et al 2022),
• counteracting inflammation and apoptosis (763: Fujii et al 2012; 373: Chen et al 2017; 635: Huo et al 2014; 382: Gao et al 2017; 969: Huang et al 2006; 897: Huang et al 2010; 985: Huang et al 2003; 103: Lu et al 2020; 1054: Qiu et al 2021; 36: Yu et al 2021; 76: Jiang et al 2020; 149: Yu et al 2020; 819: Zhou et al 2012; 294: Ikeda et al 2018; 140: Xie et al 2020; 649: Liu et al 2014; 538: Chen et al 2015; 4: Chen et al 2021; 141: Xie et al 2020; 156: Zhuang et al 2020; 650: Liu et al 2014; 152: Zhang et al 2020; 235: Tan et al 2019; 592: Tao et al 2015; 459: Yu et al 2017; 616: Zhang et al 2015; 560: Li et al 2015; 253: Yao et al 2019; 651: Liu et al 2014; 394: Iketani et al 2017; 743: Xu and Zhang 2013; 247: Yan et al 2019; 249: Yang et al 2019; 612: Zhai et al 2015; 618: Zhang, Liu, and Zhang 2015; 716: Liu et al 2013; 811: Xie et al 2012; 26: Sada et al 2021; 681: Zhang et al 2014; 22: Matsuura et al 2021; 231: Saramago et al 2019; 530: Yu et al 2016; 921: Xie et al 2010; 392: Hong et al 2017; 485: Hong et al 2016; 561: Li et al 2015; 713: Li et al 2013; 812: Xie et al 2012; 922: Xie et al 2010; 923: Xie et al 2010; 543: Du et al 2015; 378: Dang et al 2017; 220: Meng et al 2019; 597: Wang et al 2015; 627: Du et al 2014; 435: Tian et al 2017; 444: Xin et al 2017; 794: Qin et al 2012; 268: Chen et al 2018; 337: Song et al 2018; 611: Yue et al 2015; 614: Zhang et al 2015; 733: Tan et al 2013; 799: Shi et al 2012; 886: Zhang et al 2011; 907: Nakao et al 2010; 946: Sun et al 2009; 918: Sun et al 2010; 802: Sun et al 2012; 145: Yamamoto et al 2020; 252: Yao et al 2019; 663: Shigeta et al 2014; 826: Chen et al 2011; 949: Zheng et al 2009; 950: Buchholz et al 2008; 104: Lu et al 2010; 323: Nishida et al 2018; 542: Du et al 2015; 758: Abe et al 2012; 878: Wang et al 2011; 366: Zou et al 2018; 239: Uto et al 2019; 285: Ge et al 2018; 359: Zhang et al 2018; 376: Chen et al 2017; 385: Golshahi et al 2017; 401: Li et al 2017; 516: Shimada et al 2016; 652: Liu et al 2014; 809: Xiang et al 2012; 665: Tan et al 2014; 230: Saito et al 2019; 357: Zhang et al 2018; 433: Takahashi et al 2017; 504: Meng et al 2016; 566: Liu et al 2015; 754: Zhou et al 2013; 600: Wu et al 2015; 548: Haam et al 2015; 634: Huang et al 2014; 568: Luo et al 2015; 567: Liu et al 2015; 601: Xiao et al 2015; 752: Zhao et al 2013; 755: Zhou et al 2013; 407: Liu et al 2017; 519: Tamaki et al 2016; 547: Guo et al 2015; 427: Shi et al 2017; 747: Yonamine et al 2013; 774: Jin et al 2012; 345: Wang et al 2018; 546: Guo et al 2015; 647: Liu et al 2014; 801: Spulber et al 2012; 551: Homma et al 2015; 598: Wei et al 2015; 617: Zhang et al 2015; 682: Zhang et al 2014; 995: Naito et al 2002; 533: Zhang et al 2016; 626: Du et al 2014; 347: Wu et al 2018; 317: Meng et al 2018; 1114: Qian et al 2021; 1115: Zhao et al 2021; 1131: Zhang et al 2019; 1160: Bai et al 2022; 1151: Li et al 2020; 1154: Fu et al 2020; 1163: Li et al 2022),
• improving immune function (1054: Qiu et al 2021; 4: Chen et al 2021; 156: Zhuang et al 2020; 253: Yao et al 2019; 811: Xie et al 2012; 1035: Chen et al 2021; 738: Wang et al 2013; 392: Hong et al 2017; 602: Xie et al 2015; 608: Yu et al 2015; 223: Moon et al 2019; 727: Qian et al 2013; 826: Chen et al 2011; 82: Kawamura et al 2020; 113: Ozeki et al 2020; 1149: Shirakawa et al 2022),
• restoring mitochondrial (140: Xie et al 2020; 141: Xie et al 2020; 152: Zhang et al 2020; 276: Dong et al 2018; 167: Chen et al 2019; 615: Zhang et al 2015; 789: Noda et al 2012; 297: Ishikawa et al 2018; 805: Tanaka et al 2012; 657: Noda et al 2014; 399: Li et al 2017)
• and endoplasmic reticulum (166: Chen et al 2019; 32: Tong et al 2021; 307: Li et al 2018; 409: Lu et al 2017; 430: Sun et al 2017) function,
• and regulating the gut microbiome (294: Ikeda et al 2018).

 

Literature Cited (numbered as per database):

● (3) Carnovali, Marta; Mariotti, Massimo; Banfi, Giuseppe. Molecular hydrogen enhances osteogenesis in Danio rerio embryos. 2021. Journal of Fish Biology. 10.1111/jfb.14670

● (4) Chen, Hongguang; Dong, Beibei; Shi, Yuan; Yu, Yonghao; Xie, Ke-Liang. Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the Nrf2 pathway in sepsis-associated encephalopathy. 2021. Neuroscience. 10.1016/j.neuroscience.2021.05.003

● (8) Gulburun, Merve Altin; Karabulut, Ramazan; Turkyilmaz, Zafer; Eryilmaz, Sibel; Kaya, Cem; Arslan, Burak; Gulbahar, Ozlem; Poyraz, Aylar; Sonmez, Kaan. Protective effects of hydrogen rich saline solution on ventral penile mathieu type flap with penile tourniquet application in rats. 2021. Journal of Pediatric Urology. 10.1016/j.jpurol.2021.01.046

● (17) Li, Qing; Zhang, Haifang; Jia, Zhen; Zhang, Linlin; Li, Yize; Xu, Rubin; Wang, Chunyan; Yu, Yonghao. Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS nitration and NMDA receptor trafficking and functioning in the spinal cord of rats. 2021. Neuroscience Letters. 10.1016/j.neulet.2021.135847

● (22) Matsuura, Hiroshi; Matsumoto, Hisatake; Okuzaki, Daisuke; Shimizu, Kentaro; Ogura, Hiroshi; Ebihara, Takeshi; Matsubara, Tsunehiro; Hirano, Shin-Ichi; Shimazu, Takeshi. Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice. 2021. Journal of Surgical Research. 10.1016/j.jss.2021.01.022

● (23) Nie, Chaoqun; Ding, Xue; A, Rong; Zheng, Min; Li, Zhenning; Pan, Shuang; Yang, Wei. Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats. 2021. Life Sciences. 10.1016/j.lfs.2021.119248

● (24) Nishi, Kotaro; Iwai, Satomi; Tajima, Kazuki; Okano, Shozo; Sano, Motoaki; Kobayashi, Eiji. Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model. 2021. Frontiers in Immunology. 10.3389/fimmu.2020.626295

● (26) Sada, Haruki; Egi, Hiroyuki; Ide, Kentaro; Sawada, Hiroyuki; Sumi, Yusuke; Hattori, Minoru; Sentani, Kazuhiro; Oue, Naohide; Yasui, Wataru; Ohdan, Hideki. Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis. 2021. Surgery Today. 10.1007/s00595-021-02271-z

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