Studies Referencing Hydrogen and Heart - Cardiovascular

Database:

Primary Topic: Heart

Secondary Topic: Atherosclerosis/Cardiac Arrest/Cardiac Degeneration/Cardiovascular Disease (CVD)/Heart Attack (Myocardial Infarction)/Heart Failure (HF)/Hypertension (or Any)

Tertiary Topic: AngioplastyCardiac Hypertrophy/Cardiomyopathy/Cardiopulmonary Bypass (CPB)/”Fluidity/Viscosity”/Heart Rhythm/Myocardial Necrosis/Platelet Aggregation/Unstable Angina/Vascular Dysfunction (or Any)

 

Aging

● Hydrogen can help protect the heart from the effects of aging, including ameliorating cellular senescence (482: Hara et al 2016; 295: Iketani et al 2018)

and lowering American Heart Association (AHA) risk score (302: Korovljev et al 2018).

 

Ischemia-Reperfusion Injuries

● Hydrogen can safely (520: Tamura et al 2016) protect the heart from the damaging effects of ischemia/reperfusion injuries (574: Pan et al 2015; 128: Tamura et al 2020; 94: Li et al 2020; 95: Li et al 2020; 212: Li et al 2019; 213: Li et al 2019; 214: Li et al 2019; 251: Yao et al 2019; 280: Feng et al 2018; 377: Chen et al 2017; 383: Gao et al 2017; 391: He et al 2017; 798: Sakai et al 2012; 815: Yoshida et al 2012; 954: Hayashida et al 2008; 1090: Nie et al 2021; 1092: Yang et al 2021; 272: Chi et al 2018; 611: Yue et al 2015; 673: Xie et al 2014; 730: Shinbo et al 2013; 886: Zhang et al 2011; 946: Sun et al 2009; 767: Hayashida et al 2012; 1171: Gong et al 2022).

 

Atherosclerosis and Cardiovascular Disease

● Hydrogen can help alleviate

• atherosclerosis (69: Ishibashi et al 2020; 352: Yang et al 2018; 581: Salemi et al 2015; 588: Song et al 2015; 800: Song et al 2012; 870: Song et al 2011; 295: Iketani et al 2018; 662: Sakai et al 2014; 958: Ohsawa et al 2008; 761: Ekuni et al 2012; 28: Si et al 2021; 587: Song et al 2015; 822: Zong et al 2012)
• and cardiovascular disease (CVD) (84: Kiyoi et al 2020; 825: Chen et al 2011),
• by controlling oxidative stress and blood lipid profile.

● Hydrogen can help reverse coronary artery aneurysm associated with Kawasaki Disease (1178: Kuo 2022).

 

Thrombosis and Blood Viscosity

• Hydrogen aids in lowering blood viscosity (526: Weidman et al 2016; 777: Kato et al 2012)
• and risk of thrombosis (241: Wang et al 2019; 803: Takeuchi et al 2012).

 

Diabetes and Obesity

• Hydrogen suppresses Obesity- and Diabetes-induced cardiomyopathy (599: Wu et al 2015)
• and vascular dysfunction (706: Jiang et al 2013; 21: Masuda et al 2021).

 

Hypertension

● Hydrogen can help alleviate

• hypertension (492: Johansson and Sukhotskya 2016; 125: Sugai et al 2020; 557: Kishimoto et al 2015; 699: He et al 2013; 818: Zheng and Yu 2012; 879: Wang et al 2011; 286: Guan et al 2018; 1144: Kawakami et al 2022)
• and hypertension-associated conditions such as
  • cardiac hypertrophy (277: Fan et al 2018; 134: Wang and Pan 2020; 316: Matsuoka et al 2018; 816: Yu and Zheng 2012; 532: Zhang et al 2016; 1159: Yang et al 2022),
  • kidney injury (674: Xin et al 2014; 756: Zhu et al 2013; 928: Zhu et al 2010),
  • and cardiac fibrosis (450: Yang et al 2017; 1098: Liu et al 2021).

 

Sepsis

● Hydrogen is neuroprotective against sepsis-induced cardiotoxicity (128: Tamura et al 2020; 235: Tan et al 2019; 592: Tao et al 2015; 152: Zhang et al 2020).

 

Sleep Apnea and Hypoxia Injury

● Hydrogen can help prevent hypoxic-ischemic injury in people with sleep apnea (260: Zhao et al 2019; 834: Hayashi et al 2011; 639: Kato et al 2014).

 

Surgery and Transplantation

● Hydrogen constrains inflammation associated with

• Cardiopulmonary Bypass (CPB) (763: Fujii et al 2012; 175: Cole et al 2019; 373: Chen et al 2017; 268: Chen et al 2018; 337: Song et al 2018; 1084: Danilova et al 2021)
• and Angioplasty (794: Qin et al 2012; 695: Chen et al 2013; 396: Katsumata et al 2017).

● Hydrogen can improve the outcomes of

• Reperfusion Therapy (23: Nie et al 2021),
• Hypoxic Post-Conditioning (460: Zalesak et al 2017; 614: Zhang et al 2015; 615: Zhang et al 2015),
• and Deep Hypothermic Circulation Arrest (DHCA) (598: Wei et al 2015; 869: Shen et al 2011).

● Hydrogen has been shown to effectively prevent and treat morbidities resulting from the transplantation of cardiovascular tissue (733: Tan et al 2013; 918: Sun et al 2010; 1006: Ogino et al 2000; 725: Noda et al 2013; 789: Noda et al 2012; 802: Sun et al 2012; 907: Nakao et al 2010).

● Hydrogen protects against

• radiotherapy-cardiotoxicity (209: Kura et al 2019; 913: Qian et al 2010)
• and chemotherapy-induced cardiotoxicity (specifically Doxorubicin (476: Gao et al 2016; 672: Wu et al 2014))

● Hydrogen can alleviate Isoproterenol-induced cardiotoxicity (464: Zhang et al 2017; 533: Zhang et al 2016; 555: Jing et al 2015).

 

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (588: Song et al 2015; 800: Song et al 2012; 662: Sakai et al 2014; 958: Ohsawa et al 2008; 761: Ekuni et al 2012; 84: Kiyoi et al 2020; 825: Chen et al 2011; 128: Tamura et al 2020; 533: Zhang et al 2016; 555: Jing et al 2015; 599: Wu et al 2015; 706: Jiang et al 2013; 212: Li et al 2019; 280: Feng et al 2018; 383: Gao et al 2017; 391: He et al 2017; 1092: Yang et al 2021; 272: Chi et al 2018; 816: Yu and Zheng 2012; 450: Yang et al 2017; 532: Zhang et al 2016; 818: Zheng and Yu 2012; 879: Wang et al 2011; 260: Zhao et al 2019; 834: Hayashi et al 2011; 695: Chen et al 2013; 794: Qin et al 2012; 614: Zhang et al 2015; 673: Xie et al 2014;730: Shinbo et al 2013; 598: Wei et al 2015; 869: Shen et al 2011; 733: Tan et al 2013; 918: Sun et al 2010; 907: Nakao et al 2010; 777: Kato et al 2012; 241: Wang et al 2019; 767: Hayashida et al 2012; 1098: Liu et al 2021; 286: Guan et al 2018),

increasing the activity of endogenous antioxidant enzymes (555: Jing et al 2015; 706: Jiang et al 2013; 212: Li et al 2019; 280: Feng et al 2018; 816: Yu and Zheng 2012; 450: Yang et al 2017; 818: Zheng and Yu 2012; 879: Wang et al 2011; 260: Zhao et al 2019; 794: Qin et al 2012; 614: Zhang et al 2015; 869: Shen et al 2011; 733: Tan et al 2013; 918: Sun et al 2010; 1098: Liu et al 2021; 286: Guan et al 2018),

upregulating cellular protection mechanisms (482: Hara et al 2016; 352: Yang et al 2018; 588: Song et al 2015; 706: Jiang et al 2013; 94: Li et al 2020; 212: Li et al 2019; 214: Li et al 2019; 280: Feng et al 2018; 377: Chen et al 2017; 673: Xie et al 2014),

counteracting inflammation and apoptosis (574: Pan et al 2015; 352: Yang et al 2018; 870: Song et al 2011; 295: Iketani et al 2018; 695: Chen et al 2013; 825: Chen et al 2011; 209: Kura et al 2019; 128: Tamura et al 2020; 533: Zhang et al 2016; 555: Jing et al 2015; 599: Wu et al 2015; 94: Li et al 2020; 214: Li et al 2019; 251: Yao et al 2019; 391: He et al 2017; 1090: Nie et al 2021; 1092: Yang et al 2021; 272: Chi et al 2018; 277: Fan et al 2018; 134: Wang and Pan 2020; 816: Yu and Zheng 2012; 450: Yang et al 2017; 532: Zhang et al 2016; 699: He et al 2013; 818: Zheng and Yu 2012; 879: Wang et al 2011; 235: Tan et al 2019; 592: Tao et al 2015; 260: Zhao et al 2019; 834: Hayashi et al 2011; 695: Chen et al 2013; 794: Qin et al 2012; 373: Chen et al 2017; 614: Zhang et al 2015; 611: Yue et al 2015; 886: Zhang et al 2011; 598: Wei et al 2015; 869: Shen et al 2011; 733: Tan et al 2013; 918: Sun et al 2010; 725: Noda et al 2013; 789: Noda et al 2012; 1098: Liu et al 2021; 1159: Yang et al 2022; 1171: Gong et al 2022),

improving immune function (557: Kishimoto et al 2015),

and restoring mitochondrial (533: Zhang et al 2016; 815: Yoshida et al 2012; 816: Yu and Zheng 2012; 818: Zheng and Yu 2012; 63: Gvozdjakova et al 2020; 152: Zhang et al 2020; 834: Hayashi et al 2011; 725: Noda et al 2013; 789: Noda et al 2012)

and endoplasmic reticulum (599: Wu et al 2015; 383: Gao et al 2017; 260: Zhao et al 2019) function.

 

Literature Cited (numbered as per database):

● (21) Masuda, Haruchika; Sato, Atsuko; Miyata, Kumiko; Shizuno, Tomoko; Oyamada, Akira; Ishiwata, Kazuo; Nakagawa, Yoshihiro; Asahara, Takayuki. Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice. 2021. Biology. 10.3390/biology10050364

● (23) Nie, Chaoqun; Ding, Xue; A, Rong; Zheng, Min; Li, Zhenning; Pan, Shuang; Yang, Wei. Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats. 2021. Life Sciences. 10.1016/j.lfs.2021.119248

● (28) Si, Yanhong; Tian, Hua; Dong, Bingqing; Zhang, Ying; Wen, Yuanyuan; Jia, Xiubin; Li, Ying; Zhang, Aihua; Qin, Shucun. Effects of hydrogen as adjuvant treatment for unstable angina. 2021. Experimental Biology and Medicine. 10.1177/15353702211009138

● (63) Gvozdjakova, Anna; Kucharska, Jarmila; Kura, Branislav; Vancova, Olga; Rausova, Zuzana; Sumbalova, Zuzana; Ulicna, Olga; Slezak, Jan. A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats. 2020. Canadian Journal of Physiology and Pharmacology. 10.1139/cjpp-2019-0281

● (69) Ishibashi, Toru; Kawamoto, Kosuke; Matsuno, Kasumi; Ishihara, Genki; Baba, Takamichi; Komori, Nobuaki. Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial. 2020. PLoS One. 10.1371/journal.pone.0233484

● (84) Kiyoi, Takeshi; Liu, Shuang; Takemasa, Erika; Nakaoka, Hirotomo; Hato, Naohito; Mogi, Masaki. Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress. 2020. PLoS One. 10.1371/journal.pone.0227582

● (94) Li, Liangtong; Li, Xiangzi; Zhang, Zhe; Liu, Li; Liu, Tongtong; Li, Shaochun; Liu, Sen; Zhou, Yujuan; Liu, Fulin. Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury. 2020. Current Molecular Medicine. 10.2174/1566524019666191105150709

● (95) Li, Liangtong; Liu, Tongtong; Liu, Li; Zhang, Zhe; Li, shaochun; Zhang, Zhiling; Zhou, Yujuan; Liu, Fulin. Metabolomics Analysis of the Effect of Hydrogen-Rich Water on Myocardial Ischemia-Reperfusion Injury in Rats. 2020. Journal of Bioenergetics and Biomembranes. 10.1007/s10863-020-09835-7

● (125) Sugai, Kazuhisa; Tamura, Tomoyoshi; Sano, Motoaki; Uemura, Shizuka; Fujisawa, Masahiko; Katsumata, Yoshinori; Endo, Jin; Yoshizawa, Joe; Homma, Koichiro; Suzuki, Masaru; Kobayashi, Eiji; Sasaki, Junichi; Hakamata, Yoji. Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. 2020. Nature Scientific Reports. 10.1038/s41598-020-77349-8

● (128) Tamura, Tomoyoshi; Suzuki, Masaru; Hayashida, Kei; Kobayashi, Yosuke; Yoshizawa, Joe; Shibusawa, Takayuki; Sano, Motoaki; Hori, Shingo; Sasaki, Junichi. Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome. 2020. Journal of Clinical Biochemistry and Nutrition. 10.3164/jcbn.19-101

● (134) Wang, Chufeng; Pan, Zezheng. Hydrogen-rich saline mitigates pressure overload-induced cardiac hypertrophy and atrial fibrillation in rats via the JAK-STAT signalling pathway. 2020. Journal of International Medical Research. 10.1177/0300060520936415

● (152) Zhang, Yuanyuan; Dong, Aili; Xie, Keliang; Yu, Yong-Hao. Protective Effects of Hydrogen on Myocardial Mitochondrial Functions in Septic Mice. 2020. BioMed Research International. 10.1155/2020/1568209

● (175) Cole, Alexis R.; Perry, Dorothy A.; Raza, Ali; Nedder, Arthur P.; Pollack, Elizabeth; Regan, William L.; van den Bosch, Sarah J.; Polizzotti, Brian D.; Yang, Edward; Davila, Daniel; Afacan, Onur; Warfield, Simon K.; Ou, Yangming; Sefton, Brenda; Everett, Allen D.; Neil, Jeffrey J.; Lidov, Hart G.W.; Mayer, John E.; Kheir, John N. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. 2019. JACC Basic to Translational Research. 10.1016/j.jacbts.2018.11.006

● (209) Kura, Branislav; Kalocayova, Barbora; LaBaron, Tyler W.; Frimmel, Karel; Buday, Josef; Surovy, Juraj; Slezak, Jan. Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium. 2019. Molecular and Cellular Biochemistry. 10.1007/s11010-019-03512-z

● (212) Li, Liangtong; Liu, Tongtong; Liu, Li; Li, Shaochun; Zhang, Zhe; Zhang, Ruisha; Zhou, Yujuan; Liu, Fulin. Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury. 2019. Journal of Bioenergetics and Biomembranes. 10.1007/s10863-019-09814-7

● (213) Li, Liangtong; Liu, Tongtong; Li, Xiangzi; Liu, Xuanchen; Liu, Li; Li, shaochun, Li, Zhilin; Zhou, Yujuan; Liu, Fulin. Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury. 2019. International Journal of Medical Sciences. 10.7150/ijms.35984

● (214) Li, Xiangzi; Li, Liangtong; Liu, Xuanchen; Wu, Jiawen; Sun, Xiaoyu; Li, Zhilin; Geng, Yong-Jian; Liu, Fulin; Zhou, Yujuan. Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water. 2019. Current Molecular Medicine. 10.2174/1566524019666190321113544

● (235) Tan, Sihua; Long, Zhiyuan; Hou, Xiangping; Lin, Yujie; Xu, Jingting; You, Xinchao; Wang, Tinghuai; Zhang, Yaxing. H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression. 2019. Frontiers in Pharmacology. 10.3389/fphar.2019.00865

● (241) Wang, Yun; Wu, Ya-Ping; Han, Ji-Ji; Zhang, Mao-Qing; Yang, Chen-Xi; Jiao, Peng; Tian, Hua; Zhu, Chao; Qin, Shu-Cun; sun, Xue-Jun; Zhang, Han-Ting; Zhao, Xiao-Min. Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation. 2019. Life Sciences. 10.1016/j.lfs.2019.116700

● (251) Yao, Li; Chien, Hongguang; Wu, Qinghua; Xie, Ke-Liang. Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. 2019. International Journal of Molecular Medicine. 10.3892/ijmm.2019.4264

● (260) Zhao, Ya-Shou; An, Ji-Ren; Yang, Shengchang; Guan, Peng; Yu, Fu-Yang; Li, Wenya; Li, Jie-Ru; Guo, Yajing; Sun, Zhi-Min; Ji, En-Sheng. Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes Induced by Intermittent Hypoxia in Rats. 2019. Oxidative Medicine and Cellular Longevity. 10.1155/2019/7415212

● (268) Chen, Keyan; Sun, Yingjie; Diao, Yugang; Zhang, Tiezheng; Dong, Wanwei. Hydrogen‑rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus‑activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. 2018. Oncology Letters. 10.3892/ol.2018.8639

● (272) Chi, Jing; Li, Zizhou; Hong, Xiaojian; Zhao, Tong; Bie, Yueyue; Zhang, Wen; Yang, Jiaxing; Feng, Ziming; Yu, Zhouqi; Xu, Qiannan; Zhao, Luqi; Liu, Weifan; Gao, Yunan; Yang, Hongxiao; Yang, Jiemei, Liu, Jiaren; Yang, Wei.

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats. 2018. Frontiers in Physiology. 10.3389/fphys.2018.01026

● (277) Fan, Zhixin; Gao, Yufei; Huang, Zhiwei; Xue, Fenghua; Wu, Shujing; Yang, Jing; Zhu, Liqun; Fu, Lu. Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling. 2018. BMC Cardiovascular Disorders. 10.1186/s12872-018-0773-9

● (280) Feng, Rui; Cai, Mengxin; Wang, Xudan; Zhang, Juanjuan; Tian, Zhenjun. Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats. 2018. Applied Biochemistry and Biotechnology. 10.1007/s12010-018-2841-0

● (286) Guan, Peng; Lin, Xiao-Meng; Yang, Sheng-Chang; Guo, Ya-Jing; Li, Wen-Ya; Zhao, Ya-Shuo; Yu, Fu-Yang; Sun, Zhi-Min; An, Ji-Ren; Ji, En-Sheng. Hydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation. 2018. Journal of Cellular Biochemistry. 10.1002/jcb.27684

● (295) Iketani, Masumi; Sekimoto, Kanako; Igarashi, Tsutomu; Takahashi, Mayumi; Komatsu, Masaki; Sakane, Iwao; Takahashi, Hiroshi; Kawaguchi, Hideo; Ohtani-Kaneko, Ritsuko; Ohsawa, Ikuroh. Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice. 2018. Nature Scientific Reports. 10.1038/s41598-018-35239-0

● (302) Korovljev, Darinka; Stajer, Valdemar; Javorac, Dejan; Ostojic, Sergej M. Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report. 2018. European Geriatric Medicine. 10.1007/s41999-018-0087-6

● (316) Matsuoka, Hiroki; Miyata, Seiko; Okumura, Nozomi; Watanabe, Takuya; Hashimoto, Katsunori; Nagahara, Miki; Kato, Kazuko; Sobue, Sayaka; Takeda, Kozue; Ichihara, Masatoshi; Iwamoto, Takashi; Noda, Akiko. Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. 2018. Clinical and Experimental Hypertension. 10.1080/10641963.2018.1481419

● (337) Song, Dandan; Liu, Xuelei; Diao, Yugang; Sun, Yingjie; Gao, Guangjie; Zhang, Tiezheng; Chen, Keyan; Pei, Ling. Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. 2018. Molecular Medicine Reports. 10.3892/mmr.2018.9198

● (352) Yang, Sen; He, Hu; Li, Xiaofeng; Liu, Hui; Zhao, Jian; Liu, Mingming. Hydrogen attenuated oxidized low‑density lipoprotein‑induced inflammation through the stimulation of autophagy via sirtuin 1. 2018. Experimental and Therapeutic Medicine. 10.3892/etm.2018.6691

● (373) Chen, Keyan; Wang, Nan; Diao, Yugang; Dong, Wanwei; Sun, YingJie; Liu, Lidan; Wu, Xiuying. Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats. 2017. Cellular Physiology and Biochemistry. 10.1159/000484024

● (377) Chen, Ouyang; Cao, Zhiyong; Li, He; Ye, Zhouheng; Zhang, Rongjia; Zhang, Ning; Huang, Junlong; Zhang, Ting; Wang, Liping; Han, Ling; Liu, Wenwu; Sun, Xue-Jun. High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway. 2017. Nature Scientific Reports. 10.1038/s41598-017-14072-x

● (383) Gao, Yunan; Yang, Hongxiao; Chi, Jing; Xu, Qiannan; Zhao, Luqi; Yang, Weijia; Liu, Weifan; Yang, Wei. Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy. 2017. Cellular Physiology and Biochemistry. 10.1159/000481974

● (391) He, Yingjuan; Zhang, Bo; Chen, Yihuan; Jin, Qiaofeng; Wu, Junru; Yan, Fei; Zheng, Hairong. Image-Guided Hydrogen Gas Delivery for Protection from Myocardial Ischemia-Reperfusion Injury via Microbubbles. 2017. ACS Applied Materials and Interfaces. 10.1021/acsami.7b05346

● (396) Katsumata, Yoshinori; Sano, Fumiya; Abe, Takayuki; Tamura, Tomoyoshi; Fujisawa, Taishi; Shiraishi, Yasuyuki; Kohsaka, Shun; Ueda, Ikuko; Homma, Koichiro; Suzuki, Masaru; Okuda, Shigeo; Maekawa, Yuichiro; Kobayashi, Eiji; Hori, Shingo; Sasaki, Junichi; Fukuda, Keiichi; Sano, Motoaki. The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans. 2017. Circulation Journal. 10.1253/circj.CJ-17-0105

● (450) Yang, Jing; Wu, Shujing; Zhu, Liqun; Cai, Jingjing; Fu, Lu. Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats. 2017. Molecular Medicine Reports. 10.3892/mmr.2017.6849

● (460) Zalesak, Marek; Kura, Branislav; Graban, Jan; Farkasova, Veronika; Slezak, Jan; Ravingerova, Tatiana. Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention. 2017. Canadian Journal of Physiology and Pharmacology. 10.1139/cjpp-2016-0693

● (464) Zhang, Yaxing; Long, Zhiyuan; Xu, Jingting; Tan, Sihua; Zhang, Nan; Li, Anfei; Wang, Ling; Wang, Ting-Huai. Hydrogen inhibits isoproterenol‑induced autophagy in cardiomyocytes in vitro and in vivo. 2017. Molecular Medicine Reports. 10.3892/mmr.2017.7601

● (476) Gao, Yunan; Yang, Hongxiao; Fan, Yanbin; Li, Lin; Fang, Jiahui; Yang, Wei. Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis. 2016. Mediators of Inflammation. 10.1155/2016/1320365

● (482) Hara, Fumihiko; Tatebe, Junko; Watanabe, Ippei; Yamazaki, Junichi; Ikeda, Takanori; Morita, Toshisuke. Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells. 2016. Circulation Journal. 10.1253/circj.CJ-16-0227

● (492) Johansson, Benny; Sukhotskya, Svetlana. Drinking functional coherent mineral water accompanies a strengthening of the very low frequency impact on heart rate variability, and mono and multifractal heart rhythm dynamics in healthy humans. 2016. Functional Foods in Health and Disease. 10.31989/ffhd.v6i6.265

● (520) Tamura, Tomoyoshi; Hayashida, Kei; Sano, Motoaki; Suzuki, Masaru; Shibusawa, Takayuki; Yoshizawa, Joe; Kobayashi, Yosuke; Suzuki, Takeshi; Ohta, Shigeo; Morisaki, Hiroshi; Fukuda, Keiichi; Hori, Shingo. Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-in-Human Pilot Study. 2016. Circulation Journal. 10.1253/circj.CJ-16-0127

● (526) Weidman, Joseph; Holsworth Jr., Ralph E.; Brossman, Bradley; Cho, Daniel J.; St. Cyr, John; Fridman, Gregory. Effect of electrolyzed high-pH alkaline water on blood viscosity in healthy adults. 2016. Journal of the International Society of Sports Nutrition. 10.1186/s12970-016-0153-8

● (532) Zhang, Ya-Xing; Xu, Jing-Ting; You, Xin-Chao; Wang, Chen; Zhou, Ke-Wen; Li, Ping; sun, Peng; Wang, Ling; Wang, Ting-Huai. Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin-Radixin-Moesin Signaling Pathways. 2016. Chinese Journal of Physiology. 10.4077/CJP.2016.BAE365

● (533) Zhang, Yaxing; Xu, Jingting; Long, Zhiyuan; Wang, Chen; Wang, Ling; Sun, Peng; Li, Peng; Wang, Tinghuai. Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways. 2016. Frontiers in Pharmacology. 10.3389/fphar.2016.00392

● (555) Jing, Lei; Wang, Yun; Zhao, Xiao-Min; Zhao, Bing; Han, Ji-Ju; Qin, Shu-Cun; Sun, Xue-Jun. Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. 2015. Heart, Lung, and Circulation. 10.1016/j.hlc.2014.11.018

● (557) Kishimoto, Yasuaki; Kato, Taichi; Ito, Mikako; Azuma, Yoshiteru; Fukasawa, Yoshie; Ohno, Kinji; Kojima, Seiji. Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and anti-oxidant effects. 2015. Journal of Thoracic and Cardiovascular Surgery. 10.1016/j.jtcvs.2015.05.052

● (574) Pan, Z.; Zhao, Y.; Yu, H.; Liu, D.; Xu, H. Effect of hydrogen-rich saline on cardiomyocyte autophagy during myocardial ischemia-reperfusion in aged rats. 2015. National Medical Journal of China. 26710815

● (581) Salemi, Z.; Farahani, H.; Moradi, B.; Moghadasi R. Sharif. Effect of Alkaline Water on the Lipid Profile in Wistar Rats. 2015. Arborz University Medical Journal. 10.18869/acadpub.aums.4.3.184

● (587) Song, Guohua; Lin, Quanqiang; Zhao, Hui; Liu, Meiyuan; Ye, Fenglong; Sun, Yujuan; Yu, Yang; Guo, Shoudong; Jiao, Peng; Wu, Jun; Ding, Guoyong; Xiao, Qiang; Qin, Shu-Cun. Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. 2015. Journal of Clinical Endocrinology and Metabolism. 10.1210/jc.2015-1321

● (588) Song, Guohua; Zong, Chuanlong; Zhang, Zhaoqiang; Yu, Yang; Yao, Shutong; Jiao, Peng; Tian, Hua; Zhai, Lei; Zhao, Hui; Tian, Shuyan; Zhang, Xiangjian; Wu, Yun; Sun, Xuejun; Qin, Shu-Cun. Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout mice. 2015. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2015.06.018

● (592) Tao, Bingdong; Liu, L.; Wang, N.; Tong, D.; Wang, W.; Zhang, Jin. Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation. 2015. Shock. 10.1097/SHK.0000000000000467

● (598) Wei, Rong; Zhang, Rufang; Xie, Yewei; Shen, Li; Chen, Fang. Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress. 2015. Cellular Physiology and Biochemistry. 10.1159/000430122

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