Studies Referencing Hydrogen and Lipid and Metabolic Disorders and Obesity

Database:

Primary Topic: Any

Secondary Topic: Fatty Liver Disease (Nonalcoholic)/Metabolism/Metabolic Syndrome/Obesity (or Any)

Tertiary Topic: Glucose Metabolism/Lipid Metabolism (or Any)

● Hydrogen has been shown to ameliorate dyslipidemia by lowering

• triglyceride (888: Abe et al 2010; 259: Zhao et al 2019; 486: Hou et al 2016; 116: Qiu et al 2020; 303: Korovljev et al 2018; 971: Jin et al 2006; 843: Kamimura et al 2011; 438: Wang and Wang 2017; 493: Kamimura et al 2016; 463: Zhang et al 2017; 581: Salemi et al 2015; 839: Ito et al 2011; 970: Jin et al 2006; 912: Osada et al 2010; 517: Shin et al 2016; 806: Wang et al 2012)
• and LDL-cholesterol levels (731: Song et al 2013; 908: Nakao et al 2010; 116: Qiu et al 2020; 587: Song et al 2015; 822: Zong et al 2012; 800: Song et al 2012; 158: Asada, Saitoh, and Miwa 2019; 438: Wang and Wang 2017; 91: LeBaron et al 2020; 302: Korovljev et al 2018; 463: Zhang et al 2017; 581: Salemi et al 2015; 970: Jin et al 2006; 953: Gadek et al 2008; 834: Hayashi et al 2011; 912: Osada et al 2010; 956: Kajiyama et al 2008; 28: Si et al 2021; 40: Zheng et al 2021; 289: Higashimura et al 2018; 517: Shin et al 2016; 761: Ekuni et al 2012; 779: Kawai et al 2012; 806: Wang et al 2012),
• while increasing HDL-cholesterol levels (731: Song et al 2013; 908: Nakao et al 2010; 116: Qiu et al 2020; 587: Song et al 2015; 822: Zong et al 2012; 800: Song et al 2012; 463: Zhang et al 2017; 953: Gadek et al 2008).

● Hydrogen has been shown to improve

• glucose dynamics (98: Liu et al 2020; 486: Hou et al 2016; 843: Kamimura et al 2011; 461: Zhai et al 2017; 91: LeBaron et al 2020; 302: Korovljev et al 2018; 463: Zhang et al 2017; 839: Ito et al 2011; 967: Gadek, Li, and Shirahata 2006; 970: Jin et al 2006; 953: Gadek et al 2008; 992: Gadek and Shirahata 2002; 912: Osada et al 2010; 956: Kajiyama et al 2008; 40: Zheng et al 2021; 47: Asada et al 2020; 107: Ming et al 2020; 387: Guo et al 2017; 514: Settineri et al 2016; 689: Amitani et al 2013; 776: Katakura et al 2012; 806: Wang et al 2012; 850: Li et al 2011; 851: Li et al 2011; 963: Kim et al 2007; 972: Kim and Kim 2006; 1000: Shirahata et al 2001; 1010: Oda et al 1999; 1139: Ogawa et al 2021; 1164: Zou et al 2022)
• and insulin dynamics (259: Zhao et al 2019; 303: Korovljev et al 2018; 843: Kamimura et al 2011; 461: Zhai et al 2017; 463: Zhang et al 2017; 107: Ming et al 2020; 514: Settineri et al 2016; 806: Wang et al 2012; 963: Kim et al 2007; 972: Kim and Kim 2006; 993: Li et al 2002; 1000: Shirahata et al 2001; 1139: Ogawa et al 2021).

● Hydrogen has been shown to both

• ameliorate weight gain (98: Liu et al 2020; 298: Jackson et al 2018; 486: Hou et al 2016; 34: Xiao and Miwa 2021; 454: Yoneda et al 2017; 704: Ignacio et al 2013; 705: Iio et al 2013; 971: Jin et al 2006; 843: Kamimura et al 2011)
• and intensify weight loss (259: Zhao et al 2019; 303: Korovljev et al 2018; 158: Asada, Saitoh, and Miwa 2019),
• including specifically abdominal (98: Liu et al 2020; 91: LeBaron et al 2020; 517: Shin et al 2016)
• and arm (303: Korovljev et al 2018) fat.

● Hydrogen has been shown to protect the body from the harmful effects of metabolic syndrome and obesity, including

• the liver (98: Liu et al 2020; 259: Zhao et al 2019; 298: Jackson et al 2018; 486: Hou et al 2016; 704: Ignacio et al 2013; 971: Jin et al 2006; 843: Kamimura et al 2011; 207: Korovljev et al 2019; 310: Li et al 2018; 438: Wang and Wang 2017; 461: Zhai et al 2017; 40: Zheng et al 2021; 779: Kawai et al 2012),
• kidneys (833: Hashimoto et al 2011; 463: Zhang et al 2017; 40: Zheng et al 2021; 107: Ming et al 2020; 776: Katakura et al 2012),
• heart (21: Masuda et al 2021; 352: Yang et al 2018; 587: Song et al 2015; 588: Song et al 2015; 800: Song et al 2012; 958: Ohsawa et al 2008; 302: Korovljev et al 2018; 581: Salemi et al 2015; 834: Hayashi et al 2011; 761: Ekuni et al 2012; 599: Wu et al 2015),
• gingiva (454: Yoneda et al 2017; 761: Ekuni et al 2012),
• lungs (117: Qiu et al 2020),
• bones (454: Yoneda et al 2017; 387: Guo et al 2017),
• pancreas (107: Ming et al 2020; 850: Li et al 2011; 851: Li et al 2011; 963: Kim et al 2007; 972: Kim and Kim 2006; 993: Li et al 2002),
• and spleen (40: Zheng et al 2021).

● Hydrogen shows multiple modes of action, including quenching cellular ROS (888: Abe et al 2010; 984: Hamasaki et al 2003; 486: Hou et al 2016; 731: Song et al 2013; 908: Nakao et al 2010; 454: Yoneda et al 2017; 843: Kamimura et al 2011; 587: Song et al 2015; 822: Zong et al 2012; 352: Yang et al 2018; 588: Song et al 2015; 800: Song et al 2012; 958: Ohsawa et al 2008; 197: Iuchi et al 2019; 91: LeBaron et al 2020; 834: Hayashi et al 2011; 956: Kajiyama et al 2008; 40: Zheng et al 2021; 517: Shin et al 2016; 761: Ekuni et al 2012; 779: Kawai et al 2012; 47: Asada et al 2020; 107: Ming et al 2020; 776: Katakura et al 2012; 806: Wang et al 2012; 851: Li et al 2011; 1010: Oda et al 1999),

increasing the activity of endogenous antioxidant enzymes (731: Song et al 2013; 833: Hashimoto et al 2011; 908: Nakao et al 2010; 956: Kajiyama et al 2008; 517: Shin et al 2016; 107: Ming et al 2020; 806: Wang et al 2012; 851: Li et al 2011),

upregulating cellular protection mechanisms (310: Li et al 2018; 514: Settineri et al 2016),

counteracting inflammation and apoptosis (259: Zhao et al 2019; 724: Nishimura et al 2013; 731: Song et al 2013; 34: Xiao and Miwa 2021; 587: Song et al 2015; 352: Yang et al 2018; 588: Song et al 2015; 800: Song et al 2012; 310: Li et al 2018; 438: Wang and Wang 2017; 461: Zhai et al 2017; 117: Qiu et al 2020; 91: LeBaron et al 2020; 834: Hayashi et al 2011; 40: Zheng et al 2021; 107: Ming et al 2020; 590: Tamasawa et al 2015; 599: Wu et al 2015; 850: Li et al 2011; 851: Li et al 2011; 1164: Zou et al 2022),

restoring mitochondrial function (259: Zhao et al 2019; 486: Hou et al 2016; 704: Ignacio et al 2013; 197: Iuchi et al 2019; 839: Ito et al 2011; 834: Hayashi et al 2011),

and regulating the gut microbiome (259: Zhao et al 2019; 116: Qiu et al 2020; 289: Higashimura et al 2018).

Literature Cited (numbered as per database):

● (21) Masuda, Haruchika; Sato, Atsuko; Miyata, Kumiko; Shizuno, Tomoko; Oyamada, Akira; Ishiwata, Kazuo; Nakagawa, Yoshihiro; Asahara, Takayuki. Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice. 2021. Biology. 10.3390/biology10050364

● (28) Si, Yanhong; Tian, Hua; Dong, Bingqing; Zhang, Ying; Wen, Yuanyuan; Jia, Xiubin; Li, Ying; Zhang, Aihua; Qin, Shucun. Effects of hydrogen as adjuvant treatment for unstable angina. 2021. Experimental Biology and Medicine. 10.1177/15353702211009138

● (34) Xiao, Li; Miwa, Nobuhiko. Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. 2021. Cells. 10.3390/cells10030626

● (40) Zheng, Mengna; Yu, Han; Xue, Yong; Yang, Tong; Tu, Qiufen; Xiong, Kaiqing; Deng, Daihua; Lu, Lei; Huang, Nan. The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus. 2021. Molecular and Cellular Biochemistry. 10.1007/s11010-021-04145-x

● (47) Asada, Ryoko; Tazawa, Kenji; Sato, Shinkichi; Miwa, Nobuhiko. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. 2020. Medical Gas Research. 10.4103/2045-9912.296041

● (91) LaBaron, Tyler W.; Singh, Ram B.; Fatima, Ghizal; Kartikey, Kumar; Sharma, Jagdish P.; Ostojic, Sergej M.; Gvozdjakova, Anna; Kura, Branislav; Noda, Mami; Mojto, Viliam; Niaz, Mohammad Arif; Slezak, Jan. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. 2020. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 10.2147/DMSO.S240122

● (98) Liu, Boyan; Xue, Junli; Zhang, Mengyu; Wang, Mingyue; Ma, Tingting; Zhao, Min; Gu, Qianqian; Qin, Shu-Cun. Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats. 2020. Molecular Medicine Reports. 10.3892/mmr.2020.11364

● (107) Ming, Yi; Ma, Qi-Hang; Han, Xin-Li; Li, Hong-Yan. Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress. 2020. Experimental and Therapeutic Medicine. 10.3892/etm.2020.8708

● (116) Qiu, Xiangjie; Ye, Qiaona; Sun, Mengxing; Wang, Lili; Tan, Yurong; Wu, Guojun. Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet. 2020. Experimental Biology and Medicine. 10.1177/1535370219898407

● (117) Qiu, Xiangjie; Bajinka, Ousman; Wang, Lili; Wu, Guojin; Tan, Yurong. Effects of high-fat diet on the epithelial-mesenchymal transition of respiratory tract through the glyoxylic acid cycle of pulmonary microbes and the intervention of saturated hydrogen. 2020. Research Square. 10.21203/rs.3.rs-17519/v1

● (158) Asada, Ryoko; Saitoh, Yasukazu; Miwa, Nobuhiko. Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. 2019. Medical Gas Research. 10.4103/2045-9912.260647

● (197) Iuchi, Katsuya; Nishimaki, Kiyomi; Kamimura, Naomi; Ohta, Shigeo. Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction. 2019. Canadian Journal of Physiology and Pharmacology. 10.1139/cjpp-2018-0741

● (207) Korovljev, Darinka; Stajer, Valdemar; Ostojic, Jelena; LaBaron, Tyler W.; Ostojic, Sergej M. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. 2019. Gastroenterology Clinical Biology. 10.1016/j.clinre.2019.03.008

● (259) Zhao, Lin; Wang, Yan; Zhang, Guanfei; Zhang, Tiantian; Lou, Jing; Liu, Jiankang. L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet. 2019. Nutrients. 10.3390/nu11123054

● (289) Higashimura, Yasuki; Baba, Yasunori; Inoue, Ryo; Takagi, Tomohisa; Uchiyama, Kazuhiko; Mizushima, Katsura; Hirai, Yasuko; Ushiroda, Chihiro; Tanaka, Yoshinori; Naito, Yuji. Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice. 2018. Medical Gas Research. 10.4103/2045-9912.229597

● (298) Jackson, Karen; Dressler, Noa; Ben-Shushan, Rotem S.; Meerson, Ari; LeBaron, Tyler W.; Tamir, Snait. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. 2018. World Journal of Gastroenterology. 10.3748/wjg.v24.i45.5095

● (302) Korovljev, Darinka; Stajer, Valdemar; Javorac, Dejan; Ostojic, Sergej M. Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report. 2018. European Geriatric Medicine. 10.1007/s41999-018-0087-6

● (303) Korovljev, Darinka; Trivic, T.; Drid, P.; Ostojic, Sergej M. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. 2018. Irish Journal of Medical Science. 10.1007/s11845-017-1638-4

● (310) Li, Shaowei; Fujino, Masayuki; Ichimaru, Naotsugu; Kurakawa, Ryosuke; Hirano, Shinichi; Mou, Lisha; Takahara, Shiro; Takahara, Terumi; Li, Xiao-Kang. Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression. 2018. Nature Scientific Reports. 10.1038/s41598-018-32411-4

● (352) Yang, Sen; He, Hu; Li, Xiaofeng; Liu, Hui; Zhao, Jian; Liu, Mingming. Hydrogen attenuated oxidized low‑density lipoprotein‑induced inflammation through the stimulation of autophagy via sirtuin 1. 2018. Experimental and Therapeutic Medicine. 10.3892/etm.2018.6691

● (387) Guo, Jialiang; Dong, Weichong; Jin, Lin; Wang, Pengcheng; Hou, Zhiyong; Zhang, Yingze. Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin. 2017. International Orthopaedics. 10.1007/s00264-017-3581-4

● (438) Wang, Xiang; Wang, Jiao. High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3. 2017. Biological Chemistry. 10.1515/hsz-2017-0303

● (454) Yoneda, Toshiki; Tomofuji, Takaaki; Kunimoto, Muneyoshi; Ekuni, Daisuke; Irie, Koichiro; Azuma, Tatsuji; Machida, Tatsuya; Miyai, Hisataka; Fujimori, Kouhei; Morita, Manabu. Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet. 2017. Nurtients. 10.3390/nu9010064

● (461) Zhai, Xiao; Chen, Xiao; Lu, Jiancan; Zhang, Yaping; Sun, Xuejun; Huang, Qin; Wang, Qijin. Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ. 2017. Molecular Medicine Reports. 10.3892/mmr.2017.6120

● (463) Zhang, Xiaolong; Liu, Jiaming; Jin, Keke; Xu, Haifeng; Wang, Chuang; Zhang, Zhuang; Kong, Mimi; Zhang, Zhengzheng; Wang, Qingyi; Wang, Fangyan. Subcutaneous injection of H2 is a novel effective treatment for type 2 diabetes. 2017. Journal of Diabetes Investigation. 10.1111/jdi.12674

● (486) Hou, Chen; Wang, Yongyao; Zhu, Erkang; Yan, Chunhong; Zhao, Lin; Wang, Xiaojie; Qiu, Yingfeng; Shen, Hui; Sun, Xuejun; Feng, Zhihui; Liu, Jiankang; Long, Jiangang. Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. 2016. Biochemical Pharmacology. 10.1016/j.bcp.2015.12.020

● (493) Kamimura, Naomi; Ichiyama, Harumi; Iuchi, Katsuya; Ohta, Shigeo. Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism. 2016. NPJ Aging and Mechanisms of Disease. 10.1038/npjamd.2016.8

● (514) Settineri, Robert; Ji, Jin; Luo, Chunlan; Ellithorpe, Rita R.; de Mattos, Gonzalo Ferreira; Rosenblatt, Steven; La Valle, James; Jimenez, Antonio; Ohta, Shigeo; Nicolson, Garth L. Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase Activity. 2016. American Journal of Food and Nutrition. 10.12691/ajfn-4-6-4

● (517) Shin, D.; Cho, E.S.R.; Bang, H-T.; Shim, K.S. Effects of oxygenated or hydrogenated water on growth performance, blood parameters, and antioxidant enzyme activity of broiler chickens. 2016. Poultry Science. 10.3382/ps/pew237

● (581) Salemi, Z.; Farahani, H.; Moradi, B.; Moghadasi R. Sharif. Effect of Alkaline Water on the Lipid Profile in Wistar Rats. 2015. Arborz University Medical Journal. 10.18869/acadpub.aums.4.3.184

● (587) Song, Guohua; Lin, Quanqiang; Zhao, Hui; Liu, Meiyuan; Ye, Fenglong; Sun, Yujuan; Yu, Yang; Guo, Shoudong; Jiao, Peng; Wu, Jun; Ding, Guoyong; Xiao, Qiang; Qin, Shu-Cun. Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. 2015. Journal of Clinical Endocrinology and Metabolism. 10.1210/jc.2015-1321

● (588) Song, Guohua; Zong, Chuanlong; Zhang, Zhaoqiang; Yu, Yang; Yao, Shutong; Jiao, Peng; Tian, Hua; Zhai, Lei; Zhao, Hui; Tian, Shuyan; Zhang, Xiangjian; Wu, Yun; Sun, Xuejun; Qin, Shu-Cun. Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout mice. 2015. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2015.06.018

● (590) Tamasawa, Atsuko; Mochizuki, Kazuki; Hariya, Natsuyo; Saito, Miyoko; Ishida, Hidenori; Doguchi, Satako; Yanagiya, Syoko; Osonoi, Takeshi. Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients. 2015. European Journal of Pharmacology. 10.1016/j.ejphar.2015.04.051

● (599) Wu, Feng; Qiu, Yihua; Ye, Guangming; Luo, Hede; Jiang, Junsong; Yu, Feng; Zhou, Wei; Zhang, Shuai; Feng, Junzhong. Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice. 2015. Cardiovascular Pathology. 10.1016/j.carpath.2015.04.008

● (689) Amitani, Haruka; Asakawa, Akihiro; Cheng, Kaichun; Amitani, Marie; Kaimoto, Kaori; Nakano, Masako; Ushikai, Miharu; Li, Yingxiao; Tsai, Minglun; Li, Jiang-Bo; Terashi, Mutsumi; Chaolu, Huhe; Kamimura, Ryozo; Inui, Akio. Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. 2013. PLoS One. 10.1371/journal.pone.0053913

● (704) Ignacio, Rosa Mistica Coles; Kang, Tae-Young; Kim, Cheol-Su; Kim, Soo-Ki; Yang, Young-Chul; Sohn, Joon-Hyung; Lee, Kyu-Jae. Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. 2013. Biological and Pharmaceutical Bulletin. 10.1248/bpb.b12-00781

● (705) Iio, Akio; Ito, Mikako; Itoh, Tomohiro; Terazawa, Riyako; Fujita, Yasunori; Nozawa, Yoshinori; Ohsawa, Ikuroh; Ohno, Kinji; Ito, Masafumi. Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. 2013. Medical Gas Research. 10.1186/2045-9912-3-6

● (724) Nishimura, Naomichi; Tanabe, Hiroki; Adachi, Misato; Yamamoto, Tatsuro; Fukushima, Michihiro. Colonic Hydrogen Generated from Fructan Diffuses into the Abdominal Cavity and Reduces Adipose mRNA Abundance of Cytokines in Rats. 2013. Journal of Nutrition. 10.3945/jn.113.183004

● (731) Song, Guohua; Li, Min; Sang, Hui; Zhang, Liying; Li, Xiuhong; Yao, Shutong; yu, Yang; Zong, Chuanlong; Xue, Yazhuo; Qin, Shu-Cun. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. 2013. Journal of Lipid Research. 10.1194/jlr.M036640

● (761) Ekuni, Daisuke; Tomofuji, Takaaki; Endo, Yasumasa; Kasuyama, Kenta; Irie, Koichiro; Azume, Tatsuji; Tamaki, Naofumi; Mizutani, Shinsuke; Kojima, Azusa; Morita, Manabu. Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. 2012. Archives or Oral Biology. 10.1016/j.archoralbio.2012.04.013

● (776) Katakura, Masanori; Hashimoto, Michio; Tanabe, Yoko; Shido, Osamu. Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. 2012. Medical Gas Research. 10.1186/2045-9912-2-18

● (779) Kawai, Daisuke; Takaki, Akinobu; Nakatsuka, Atsuko; Wada, Jun; Tamaki, Naofumi; Yasunaka, Tatsuya; Koike, Kasuko; Tsuzaki, Ryuichiro; Matsumoto, Kazuyuki; Miyake, Yasuhiro; Shiraha, Hidenori; Morita, Manabu; Makino, Hirofumi; Yamamoto, Kazuhide. Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. 2012. Hepatology. 10.1002/hep.25782

● (800) Song, Guohua; Tian, Hua; Qin, Shucun; Sun, Xuejun; Yao, Shutong; Zong, Chuanlong; Luo, Yingying; Liu, Jia; Yu, Yang; Sang, Hui; Wang, Xinnong. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. 2012. Atherosclerosis. 10.1016/j.atherosclerosis.2011.11.043

● (806) Wang, Qi-Jin; Zha, Xiao-Juan; Kang, Zhi-Min; Xu, Mao-Jin; Huang, Qin; Zou, Da-Jin. Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. 2012. Chinese Medical Journal. 10.3760/cma.j.issn.0366-6999.2012.09.020

● (822) Zong, Chuanlong; Song, Guohua; Yao, Shutong; Li, Luqin; Yu, Yang; Feng, Lei; Guo, Shoudong; Luo, Tian; Qin, Shu-Cun. Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. 2012. Metabolism. 10.1016/j.metabol.2011.10.014

● (833) Hashimoto, Michio; Katakura, Masanori; Nabika, Toru; Tanabe, Yoko; Hossain, Shahdat; Tsuchikura, Satoru; Shido, Osamu. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Lepr cp /NDmcr rat - A metabolic syndrome rat model. 2011. Medical Gas Research. 10.1186/2045-9912-1-26

● (834) Hayashi, Tetsuya; Yoshioka, Toshitaka; Hasegawa, Kenichi; Miyamura, Masatoshi; Mori, Tatsuhiko; Ukimura, Akira; Matsumura, Yasao; Ishizaka, Nobukazu. Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. 2011. AJP Heart and Circulatory Physiology. 10.1152/ajpheart.00150.2011

● (839) Ito, Mikako; Ibi, Tohru; Sahashi, Ko; Ichihara, Masashi; Ito, Masafumi; Ohno, Kinji. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. 2011. Medical Gas Research. 10.1186/2045-9912-1-24

● (843) Kamimura, Naomi; Nishimaki, Kiyomi; Ohsawa, Ikuroh; Ohta, Shigeo. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. 2011. Obesity. 10.1038/oby.2011.6

● (850) Li, Yuping; Hamasaki, Takeki; Nakamichi, Noboru; Kashiwagi, Taichi; Komatsu, Takaaki; Ye, Jun; Teruya, Kiichiro; Abe, Masumi; Yan, Hanxu; Kinjo, Tomoya; Kabayama, Shigeru; Kawamura, Munenori; Shirahata, Sanetaka. Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. 2011. Cytotechnology. 10.1007/s10616-010-9317-6

● (851) Li, Yuping; Hamasaki, Takeki; Teruya, Kiichiro; Nakamichi, Noboru; Gadek, Zbigniew; Kashiwagi, Taichi; Yan, Hanxu; Kinjo, Tomoya; Komatsu, Takaaki; Ishii, Yoshitoki; Shirahata, Sanetaka. Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus. 2011. Cytotechnology. 10.1007/s10616-011-9414-1

● (888) Abe, Masumi; Sato, Shunpei; Toh, Kazuko; Hamasaki, Takeki; Nakamichi, Noboru; Teruya, Kiichiro; Katakura, Yoshinori; Morisawa, Shinkatsu; Shirahata, Sanetaka. Suppressive Effect of ERW on Lipid Peroxidation

and Plasma Triglyceride Level. 2010. Animal Cell Technology: Basic and Applied Aspects. 10.1007/978-90-481-3892-0_52

● (908) Nakao, Atsunori; Toyoda, Yoshiya; Sharma, Prachi; Evans, Malkanthi; Guthrie, Najla. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. 2010. Journal of Clinical Biochemistry and Nutrition. 10.3164/jcbn.09-100

● (912) Osada, Kazuhiro; Li, Yuping; Hamasaki, Takeki; Abe, Masumi; Nakamichi, Noboru; Teruya, Kiichiro; Ishii, Yoshitoki; Wang, Ying; Katakura, Yoshinori; Shirahata, Sanetaka. Anti-Diabetes Effects of Hita Tenryou-Sui Water®, a Natural Reduced Water. 2010. Animal Cell Technology: Basic and Applied Aspects. 10.1007/978-90-481-3892-0_51

● (953) Gadek, Zbigniew; Hamasaki, Takeki; Shirahata, Sanetaka. “Nordenau Phenomenon” – Application of Natural Reduced Water to Therapy. 2008. Animal Cell Technology: Basic and Applied Aspects. 10.1007/978-1-4020-9646-4_41

● (956) Kajiyama, Sizuo; Hasegawa, Goji; Asano, Mai; Hosoda, Hiroko; Fukui, Michiaki; Nakamura, Naoto; Kitawaki, Jo; Imai, Saeko; Nakano, Koji; Ohta, Mitsuhiro; Adachi, Tetsuo; Obayashi, Hiroshi; Yoshikawa, Toshikazu. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. 2008. Nutrition Research. 10.1016/j.nutres.2008.01.008

● (958) Ohsawa, Ikuroh; Nishimaki, Kiyomi; Yamagata, Kumi; Ishikawa, Masahiro; Ohta, Shigeo. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. 2008. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2008.10.156

● (963) Kim, Mi-Ja; Jung, Kyung Hee; Uhm, Yoon Kyung; Leem, Kang-Hyun; Kim, Hye Kyung. Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. 2007. Biological and Pharmaceutical Bulletin. 10.1248/bpb.30.234

● (967) Gadek, Zbigniew; Li, Yuping; Shirahata, Sanetaka. Influence of natural reduced water on relevant tests parameters and reactive oxygen species concentration in blood of 320 diabetes patients in the prospective observation procedure. 2006. Animal Cell Technology: Basic and Applied Aspects. 10.1007/1-4020-4457-7_51

● (970) Jin, Dan; Ryu, Sung Hoon; Kim, Hyun Won; Yang, Eun Ju; Lim, Soo Jung; Ryang, Yong Suk; Chung, Choon Hee; Park, Seung Kyu; Lee, Kyu-Jae. Anti-diabetic effect of alkaline-reduced water on OLETF rats. 2006. Bioscience, Biotechnology, and Biochemistry. 10.1271/bbb.70.31

● (971) Jin, Dan; Park, Seung Kyu; Lee, Young Mi; Yoon, Yang Suk; Kim, Dong Heui; Deung, Young Kim; Lee, Kyu-Jae. Effect of mineral-induced alkaline reduced water on sprague-dawley rats fed on high-fat diet. 2006. Journal of Experimental Biomedical Science. http://www.bslonline.org/journal/view.html?uid=146&pn=mostread&vmd=Full

● (972) Kim, Mi-Ja; Kim, Hye Kyung; Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. 2006. Life Sciences. 10.1016/j.lfs.2006.07.027

● (984) Hamasaki, Takeki; Sugihara, Y.; Teruya, K.; Kabayama, S.; Katakura, Y.; Otsubo, K.; Morisawa, S.; Shirahata, Sanetaka. The Suppressive Effect of Electrolyzed Reduced Water on Lipid Peroxidation. 2003. Animal Cell Technology: Basic and Applied Aspects. 10.1007/978-94-017-0726-8_66

● (992) Gadek, Zbigniew; Shirahata, Sanetaka. Changes in the Relevant Test Parameters of 101 Diabetes Patients under the Influence of the So-Called “Nordenau-Phenomenon”. 2002. Animal Cell Technology: Basic and Applied Aspects. 10.1007/978-94-017-0728-2_74

● (993) Li, Yuping; Nishimura, Tomohiro; Teruya, Kiichiro; Maki, Tei; Komatsu, Takaaki; Hamasaki, Takeki; Kashiwagi, Taichi; Kabayama, Shigeru; Shim, Sun-Yup; Katakura, Yoshinori; Osada, Kazuhiro; Kawahara, Takeshi; Otsubo, Kazumichi; Morisawa, Shinkatsu; Ishii, Yoshitoki; Gadek, Zbigniew; Shirahata, Sanetaka. Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. 2002. Cytotechnology. 10.1023/A:1023936421448

● (1000) Shirahata, Sanetaka; Nishimura, T.; Kabayama, S.; Aki, D.; Teruya, K.; Otsubo, K.; Morisawa, S.; Ishii, Y.; Gadek, Z.; Katakura, Yoshinori. Anti-Oxidative Water Improves Diabetes. 2001. Animal Cell Technology: From Target to Market. 10.1007/978-94-010-0369-8_137

● (1010) Oda, M.; Kusumoto, K.; Teruya, K.; Hara, T.; Maki, T.; Kabayama, S.; Katakura, Y.; Otsubo, K.; Morisawa, S.; Hayashi, H.; Ishii, Y.; Shirahata, Sanetaka. Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes. 1999. Animal Cell Technology: Products from Cells, Cells as Products. 10.1007/0-306-46875-1_90

● (1139) Ogawa, Susumu; Ohsaki, Yusuke; Shimizu, Manami; Nako, Kazuhiro; Okamura, Masashi; Kabayama, Shigeru; Tabata, Kiyoshi; Tanaka, Yasuhisa; Ito, Sadoyoshi. Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial. 2021. Diabetology International. 10.1007/s13340-021-00524-3