Studies Referencing Hydrogen and Cancer/Chemotherapy

Whole Body – Cancer and Chemotherapy

Database:

Primary Topic: Any

Secondary Topic: Cancer

Tertiary Topic: Chemotherapy Toxicity (Bleomycin)/Chemotherapy Toxicity (Cisplatin)/Chemotherapy Toxicity (Doxorubicin)/Chemotherapy Toxicity (Gefitinib)/Chemotherapy Toxicity (mFOLFOX6)/Chemotherapy Toxicity (Nitrilotriacetate)/Chemotherapy Toxicity (Oxaliplatin)/Novel Therapy/Oncogenesis/Radioprotection (or Any)

Cancer

• Hydrogen has shown efficacy as a carcinostatic in
  • gastric (27: Saitoh et al 2021; 42: Zhu, Cui, and Xu 2021; 51: Chaves et al 2020; 180: Fan et al 2019; 171: Chen et al 2019; 210: Kurokawa et al 2019),
  • colorectal (157: Akagi and Baba 2019; 579: Runtuwene et al 2015; 781: Kim, Fischer, and Hung 2012; 1097: Zan et al 2021; 1126: Zan et al 2021; 1168: Zhang et al 2022),
  • oral (29: Takemoto et al 2021; 306: Kusinoki et al 2018; 1140: Asgharzadeh et al 2022),
  • tongue (81: Kato, Saitoh, and Miwa 2020; 945: Saitoh et al 2009; 959: Saitoh et al 2008),
  • esophageal (12: Kato, Saitoh, and Miwa 2021; 81: Kato, Saitoh, and Miwa 2020; 403: Li, Tanaka, and Miwa 2017),
  • gallbladder (169: Chen et al 2019; 170: Chen et al 2019),
  • kidney (712: Li et al 2013), liver (33: Wu et al 2021),
  • lung (100: Liu et al 2020; 106: Meng et al 2020; 171: Chen et al 2019; 299: Jiang et al 2018; 343: Wang et al 2018; 961: Ye et al 2008; 996: Shirahata et al 2002; 999: Komatsu et al 2001; 1014: Shirahata et al 1998; 93: Chen et al 2020; 43: Akagi and Baba 2020; 52: Chen et al 2020),
  • brain (168: Chen et al 2019; 215: Liu et al 2019; 229: Qi et al 2019; 353: Yang et al 2018),
  • skin (208: Kou et al 2019; 353: Yang et al 2018; 1025: Dole, Wilson, and Fife 1975; 1078: Zhao et al 2018),
  • breast (208: Kou et al 2019; 229: Qi et al 2019; 256: Zhang et al 2019; 281: Frajese et al 2018; 1057: Wang et al 2020; 1074: Liu et al 2020; 1078: Zhao et al 2018),
  • endometrial (147: Yang et al 2020), cervical (208: Kou et al 2019; 353: Yang et al 2018; 417: Nakamura and Muraoka 2017; 775: Kagawa et al 2012; 1014: Shirahata et al 1998; 1028: Chu et al 2021; 1078: Zhao et al 2018; 1079: Zhou et al 2019),
  • ovarian (115: Qiao et al 2020; 332: Shang et al 2018), bladder (1075: Sun et al 2020), 
  • leukemia (906: Nakanishi et al 2010; 947: Tsai et al 2009; 987: Komatsu et al 2003),
  • carcinoma (580: Saitoh et al 2015; 890: Asada et al 2010; 1051: Bai et al 2021; 1080: Xu et al 2021; 1172: Yang et al 2022),
  • and sarcoma (782: Kinjo et al 2012; 975: Nishikawa et al 2006; 979: Nishikawa et al 2005; 999: Komatsu et al 2001; 1014: Shirahata et al 1998) cancers.
• Hydrogen shows multiple modes of action against cancer cells, including reducing ROS in non-cancerous cells (182: Gao et al 2019; 237: Terasaki et al 2019; 261: Zhou et al 2019; 476: Gao et al 2016; 975: Nishikawa et al 2006; 979: Nishikawa et al 2005)
  • while producing ROS in cancer cells (27: Saitoh et al 2021; 256: Zhang et al 2019; 580: Saitoh et al 2015; 959: Saitoh et al 2008; 1028: Chu et al 2021; 1057: Wang et al 2020; 1075: Sun et al 2020),
  • increasing the activity of endogenous antioxidants (i.e. L-ascorbic acid (Vitamin C) (12: Kato, Saitoh, and Miwa 2021), Glutathione (182: Gao et al 2019; 271: Cheng et al 2018),
  • and Coenzyme Q9/10 (43: Akagi and Baba 2020))
  • and antioxidant enzymes (261: Zhou et al 2019; 271: Cheng et al 2018; 299: Jiang et al 2018),
  • mediating inflammation (29: Takemoto et al 2021; 42: Zhu, Cui, and Xu 2021; 182: Gao et al 2019; 261: Zhou et al 2019; 281: Frajese et a; 2018; 451: Yang et al 2017; 476: Gao et al 2016; 782: Kinjo et al 2012; 1014: Shirahata et al 1998; 1028: Chu et al 2021),
  • decreasing telomere length in cancer cells (996: Shirahata et al 2002),
  • upregulating cancer cell apoptosis, pyroptosis, and autophagy (27: Saitoh et al 2021; 100: Liu et al 2020; 42: Zhu, Cui, and Xu 2021; 51: Chaves et al 2020; 106: Meng et al 2020; 147: Yang et al 2020; 281: Frajese et al 2018; 299: Jiang et al 2018; 343: Wang et al 2018; 403: Li et al 2017; 579: Runtuwene et al 2015; 580: Saitoh et al 2015; 781: Kim, Fischer, and Hung 2012; 890: Asada et al 2010; 906: Nakanishi et al 2010; 947: Tsai et al 2009; 959: Saitoh et al 2008; 1028: Chu et al 2021; 1126: Zan et al 2021),
  • and suppressing cancer cell proliferation and migration (27: Saitoh et al 2021; 229: Qi et al 2019; 299: Jiang et al 2018; 332: Shang et al 2018; 343: Wang et al 2018; 403: Li et al 2017; 417: Nakamura and Muraoka 2017; 580: Saitoh et al 2015; 782: Kinjo et al 2012; 959: Saitoh et al 2008; 961: Ye et al 2008; 987: Komatsu et al 2003; 999: Komatsu et al 2001; 1028: Chu et al 2021).

Chemotherapy and Radiotherapy

• Hydrogen protects against radiation therapy-induced tissue damage, including
  • bone-marrow damage (9: Hirano et al 2021; 188: Hirano et al 2019; 479: Guo et al 2016; 512: Qin et al 2016; 462: Zhang et al 2017),
  • immune senescence (479: Guo et al 2016; 814: Yang et al 2012),
  • osteonecrosis (53: Chen et al 2020),
  • cardionecrosis (209: Kura et al 2019),
  • gastrointestinal toxicity (350: Xiao et al 2018; 118: Qiu et al 2020),
  • lung damage (875: Terasaki et al 2011),
  • reproductive toxicity (479: Guo et al 2016),
  • cognitive dysfunction (216: Liu et al 2019),
  • hearing loss (1173: Kong et al 2022),
  • and skin injury (261: Zhou et al 2019; 643: Kunos, Abdallah, and Lyons 2014; 720: Mei et al 2013).
• Hydrogen alleviates chemotherapy-induced tissue damage, including
  • lung fibrosis (specifically Bleomycin treatment (182: Gao et al 2019; 1113: Aokage et al 2021)),
  • hepatotoxicity (specifically mFOLFOX6 (451: Yang et al 2017)
  • and Doxorubicin (476: Gao et al 2016) treatments),
  • cardiotoxicity (specifically Doxorubicin treatment (476: Gao et al 2016; 672: Wu et al 2014)),
  • nephrotoxicity (specifically Cisplatin treatment (271: Cheng et al 2018; 860: Matsushita et al 2011; 902: Kitamura et al 2010; 942: Nakashima-Kamimura et al 2009)),
  • neuropathic pain (specifically Oxaliplatin treatment (19: Lian et al 2021)),
  • interstitial pneumonia (specifically Gefitinib treatment (237: Terasaki et al 2019)),
  • ototoxicity (specifically Cisplatin treatment (380: Fransson et al 2017; 641: Kikkawa et al 2014; 868: Qu et al 2011)),
  • reproductive toxicity (specifically Cisplatin treatment (570: Meng et al 2015)),
  • and immune senescence (52: Chen et al 2020)
    • (specifically Nivolumab (43: Akagi and Baba 2020; 263: Akagi 2018),
    • XELOX/CapeOX (157: Akagi and Baba 2019),
    • and Bevacizumab (157: Akagi and Baba 2019) treatments).
• Hydrogen improves the efficacy of hematopoietic stem cell transplantation (HSCT) for the treatment hematologic malignancies by alleviating acute graft-versus-host disease (aGVHD) (610: Yuan et al 2015).
• Hydrogen improves the quality of life of cancer patients by reducing weight gain, fatigue, nausea, and insomnia, and improving cognitive function, pain, appetite, and digestive issues (171: Chen et al 2019; 479: Guo et al 2016; 844: Kang et al 2011; 93: Chen et al 2020).
• Hydrogen shows multiple modes of action of improving cancer outcomes and quality of life during treatment, including
  • reducing ROS (570: Meng et al 2015; 641: Kikkawa et al 2014; 672: Wu et al 2014; 712: Li et al 2013; 844: Kang et al 2011; 875: Terasaki et al 2011; 942: Nakashima-Kamimura et al 2009; 814: Yang et al 2012; 1140: Asgharzadeh et al 2022),
  • increasing the activity of endogenous antioxidant enzymes (570: Meng et al 2015; 712: Li et al 2013),
  • regulating the gut microbiome (19: Lian et al 2021; 350: Xiao et al 2018),
  • restoring mitochondrial function (712: Li et al 2013; 43: Akagi and Baba 2020),
  • and mediating inflammation (209: Kura et al 2019; 570: Meng et al 2015; 610: Yuan et al 2015; 672: Wu et al 2014; 712: Li et al 2013; 860: Matsushita et al 2011; 875: Terasaki et al 2011; 902: Kitamura et al 2010; 942: Nakashima-Kamimura et al 2009; 1113: Aokage et al 2021).

Literature Cited (numbered as per database):

• (9) Hirano, Shin-Ichi; Aoki, Yukimasa; Li, Xiao-Kang; Ichimaru, Naotsugu; Takahara, Shiro; Takefuji, Yoshiyasu. Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study. 2021. Medical Gas Research. 10.4103/2045-9912.314329
• (12) Kato, Shinya; Saitoh, Yasukazu; Miwa, Nobuhiko. Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen. 2021. Human Cell. 10.1007/s13577-020-00462-3
• (19) Lian, Naqi; Shen, Mengxi; Zhang, Kai; Pan, Jiacheng; Jiang, Yi; Yu, Yang; Yu, Yonghao. Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. 2021. Journal of Pain Research. 10.2147/JPR.S288289
• (27) Saitoh, Yasukazu; Kawasaki, Naho; Eguchi, Natsumi; Ikeshima, Minoru. Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4. 2021. Free Radical Research. 10.1080/10715762.2021.1902514
• (29) Takemoto, Tomoko; Kaetsu, Ryo; Hanayama, Machiko; Ishiyama, Yuuichi; Sadamura, Masayuki; Nishio, Kensuke; Tsunoda, Mariko; Asano, Masatake; Motoyoshi, Mitsuru. Acid-electrolyzed functional water-induces Interleukin-1α release from Intracellular Storage Sites in Oral Squamous Cell Carcinoma. 2021. International Journal of Medical Sciences. 10.7150/ijms.53999
• (33) Wu, Ying; Su, Lichao; Yuan, Meng; Chen, Tao; Ye, Jiamin; Jiang, Yifan; Song, Jibin; Yang, Huanghao. In vivo X-ray triggered catalysis of H2 generation for cancer synergistic gas-radiotherapy. 2021. Angewandte Chemie. 10.1002/anie.202100002
• (42) Zhu, Baocheng; Cui, Hengguan; Xu, Weiqiang. Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis. 2021. Cancer Cell International. 10.1186/s12935-020-01743-5
• (43) Akagi, Junji; Baba, Hideo. Hydrogen gas activates coenzyme Q10 to restore exhausted CD8 + T cells, especially PD-1 + Tim3 + terminal CD8 + T cells, leading to better nivolumab outcomes in patients with lung cancer. 2020. Oncology Letters. 10.3892/ol.2020.12121
• (51) Chaves, Juliana R.; de Souza, Carolina R.T.; Modesto, Antonio A.C.; Moreira, Fabiano C.; Teixeira, Eliel B.; Sarraf, Jonathan S.; Allen, Thais S.R.; Araujo, Taissa M.T.; Khayat, Andre S. Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c). 2020. American Journal of Translational Research. 32774757
• (52) Chen, Ji-Bing; Kong, Xiao-Feng; Qian, Wei; Mu, Feng; Lu, Tian-Yu; Lu, You-Yong; Xu, Ke-Cheng. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. 2020. Medical Gas Research. 10.4103/2045-9912.304221
• (53) Chen, Y.; Zong, C.; Jia, J.; Liu, Y.; Zhang, Z,; Cai, B.; Tian, L. A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats. 2020. International Journal of Oral and Maxillofacial Surgery. 10.1016/j.ijom.2020.04.011
• (81) Kato, Shinya; Saitoh, Yasukazu; Miwa, Nobuhiko. Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality. 2020. Human Cell. 10.1007/s13577-020-00402-1
• (93) Chen, Ji-Bing; Kong, Xiao-Feng; Mu, Feng; Lu, Tian-Yu; Lu, You-Yong; Xu, Ke-Cheng. Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer. 2020. Medical Gas Research. 10.4103/2045-9912.285560
• (100) Liu, Leyuan; Yan, Zhenfeng; Wang, Yuanyuan; Meng, Jinghong; Chen, Gang. Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis. 2020. Oncology Letters. 10.3892/ol.2020.11973
• (106) Meng, Jinghong; Liu, Leyuan; Wang, Dongchang; Yan, Zhenfeng; Chen, Gang. Hydrogen gas represses the progression of lung cancer via downregulating CD47. 2020. Bioscience Reports. 10.1042/BSR20192761
• (115) Qiao, Shuang; Wang, Yongjie; Zan, Rui; Wu, Hongliu; Sun, Yu; Peng, Hongzhou; Zhang, Rui; Song, Yang; Ni, Jiahua; Zhang, Shaoxiang; Zhang, Xiaonong. Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor. 2020. ACS Biomaterials Science and Engineering. 10.1021/acsbiomaterials.9b01703
• (118) Qiu, Xiaochen; Dong, Kaisheng; Guan, Jingzhi; He, JianMiao. Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and inflammatory response. 2020. International Immunopharmacology. 10.1016/j.intimp.2020.106517
• (147) Yang, Ye; Liu, Ping Yin; Bao, Wei; Chen, Song Jun; Wu, Fang Su; Zhu, Ping Ya. Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. 2020. BMC Cancer. 10.1186/s12885-019-6491-6
• (157) Akagi, Junji; Baba, Hideo. Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.          2019. Oncology Reports. 10.3892/or.2018.6841
• (168) Chen, Ji-Bing; Mu, Feng; Lu, Tianyu; Du, Duanming; Xu, Ke-Cheng. Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report. 2019. OncoTargets and Therapy. 10.2147/OTT.S235195
• (169) Chen, Ji-Bing; Mu, Feng; Lu, Tianyu; Ma, Yangyang; Du, Duanming; Xu, Ke-Cheng. A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation. 2019. OncoTargets and Therapy. 10.2147/OTT.S227217
• (170) Chen, Ji-Bing; Pan, Zhong-Bao; Du, Duan-Ming; Qian, Wei; Ma, Yang-Yang; Mu, Feng; Xu, Ke-Cheng. Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. 2019. World Journal of Clinical Cases. 10.12998/wjcc.v7.i15.2065
• (171) Chen, Ji-Bing; Kong, Xiao-Feng; Lv, You-Yong; Qin, Shu-Qun; Sun, Xue-Jun; Mu, Feng; Lu, Tian-Yu; Xu, Ke-Cheng. Real world survey' of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients. 2019. Medical Gas Research. 10.4103/2045-9912.266985
• (180) Fan, Mingjian; Wen, Yanyuan; Ye, Dien; Jin, Zhaokui; Zhao, Penghe; Chen, Danyang; Lu, Xifeng; He, Qianjun. Acid‐Responsive H2‐Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy. 2019. Advanced Healthcare Materials. 10.1002/adhm.201900157
• (182) Gao, Li; Jiang, Dingyuan; Geng, Jing; Dong, Run; Dai, Huaping. Hydrogen inhalation attenuated bleomycin‐induced pulmonary fibrosis by inhibiting TGF‐β1 and relevant oxidative stress and EMT. 2019. Experimental Physiology. 10.1113/EP088028
• (188) Hirano, Shin-Ichi; Aoki, Yukimasa; Kurokawa, Ryosuke; Li, Xiao-Kang; Ichimaru, Naotsugu; Takahara, Shiro; Takefuji, Yoshiyasu. Hydrogen Gas Inhalation Alleviates Radiation-Induced Bone Marrow Damage in Cancer Patients. 2019. SSRN Electronic Journal. 10.2139/ssrn.3349228
• (208) Kou, Zhu; Zhao, Penghe; Wang, Zhihao; Jin, Zhaokui; Chen, Lihua; Su, Bao-Lian; He, Qianjun. Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy. 2019. Journal of Materials Chemistry B. 10.1039/C9TB00338J
• (209) Kura, Branislav; Kalocayova, Barbora; LaBaron, Tyler W.; Frimmel, Karel; Buday, Josef; Surovy, Juraj; Slezak, Jan. Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium. 2019. Molecular and Cellular Biochemistry. 10.1007/s11010-019-03512-z
• (210) Kurokawa, Hiromi; Matsui, Hirofumi; Ito, Hiromu; Taninaka, Atsushi; Shigekawa, Hidemi; Dodbiba, Gjergj; Wei, Yuezhou; Fujita, Toyohisa. Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth. 2019. Biomedical Journal of Scientific and Technical Research. 10.26717/BJSTR.2019.19.003361
• (215) Liu, Meng-Yu; Xie, Fei; Zhang, Yan; Wang, Ting-Ting; Ma, Sheng-Nan; Zhao, Peng-Xiang; Zhang, Xin; Lebaron, Tyler W.; Yan, Xin-Long; Ma, Xue-Mei. Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation. 2019. Stem Cell Research and Therapy. 10.1186/s13287-019-1241-x
• (216) Liu, Mengya; Yuan, Hui; Yin, Jingling; Wang, Ruoqi; Song, Jianbo; Hu, Bo; Li, Jianguo           ; Qin, Xiujun. Effect of Hydrogen-Rich Water on Radiation-Induced Cognitive Dysfunction in Rats. 2019. Radiation Research. 10.1667/RR15464.1
• (229) Qi, Guohua; Wang, Bo; Song, Xiangfu; Li, Haijuan; Jin, Yongdong. A green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry. 2019. National Science Review. 10.1093/nsr/nwz199
• (237) Terasaki, Yasuhiro; Suzuki, Tetsuya; Tonaki, Kozue; Terasaki, Mika; Kuwahara, Naomi; Ohsiro, Jumi; Iketani, Masumi; Takahashi, Mayumi; Hamanoue, Makoto; Kajimoto, Yusuke; Hattori, Seisuke; Kawaguchi, Hideo; Shimizu, Akira; Ohsawa, Ikuroh. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. 2019. Laboratory Investigation. 10.1038/s41374-019-0187-z
• (256) Zhang, Cheng; Zheng, Di-Wei; Li, Chu-Xin; Zou, Mei-Zhen; Yu, Wu-Yang; Liu, Miao-Deng; Peng, Si-Yuan; Zhong, Zhen-Lin            ; Zhang, Xian-Zheng. Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant tumor. 2019. Biomaterials. 10.1016/j.biomaterials.2019.119472
• (261) Zhou, Ping; Lin, Bin; Wang, Peng; Pan, Tao; Wang, Shun; Chen, Weisi; Cheng, Shaowen; Liu, Sha. The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats. 2019. Journal of Radiation Research. 10.1093/jrr/rry074
• (263) Akagi, Junji. Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients. 2018. Cancer and Chemotherapy. 30382050
• (271) Cheng, Tse-Chou; Hsu, Yu-Wen; Lu, Fung-Jou; Chen, Ya-Yu; Tsai, Nu-Man; Chen, Wen-Kang; Tsai, Chia-Fang. Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice. 2018. Journal of the Chinese Medical Association. 10.1016/j.jcma.2017.08.014
• (281) Frajese, Giovanni Vanni; Benvenuto, Monica; Mattera, Rosanna; Giampaoli, Saverio; Ambrosin, Elena; Bernardini, Roberta; Giganti, Maria Gabriella; Albonici, Loredana; Dus, Ivan; Manzari, Vittorio; Modesti, Andrea; Mattei, Maurizio; Bei, Roberto. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. 2018. Evidence-Based Complementary and Alternative Medicine. 10.1155/2018/4753507
• (299) Jiang, Yu; Liu, Gang; Zhang, Li; Cheng, Sheng; Luo, Chun; Liao, Yang; Guo, Shuliang. Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. 2018. Molecular Medicine Reports. 10.3892/mmr.2018.9168
• (306) Kusinoki, Masafumi; Sata, Eri; Nishio, Kensuke; Tanaka, Takayoshi; Nishida, Tetsuya; Sugano, Naoyuki; Sato, Shuichi; Asano, Masatake. Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines. 2018. International Journal of Medical Sciences. 10.7150/ijms.26186
• (332) Shang, Lei; Xie, Fei; Li, Jiala; Zhang, Yating; Liu, Mengyu; Zhao, Pengxiang; Ma, Xuemei; Lebaron, Tyler W. Therapeutic potential of molecular hydrogen in ovarian cancer. 2018. Translational Cancer Research. 10.21037/tcr.2018.07.09
• (343) Wang, Dongchang; Wang, Lifei; Zhang, Yu; Zhao, Yunxia; Chen, Gang. Hydrogen gas inhibits lung cancer progression through targeting SMC3. 2018. Biomedicine and Pharmacotherapy. 10.1016/j.biopha.2018.05.055
• (350) Xiao, Hui-Wen; Li, Yuan; Luo, Dan; Dong, Jia-Li; Zhou, Li-Xin; Zhao, Shu-Yi; Zheng, Qi-Sheng; Wang, Hai-Chao; Cui, Ming; Fan, Sai-Jun.Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota. 2018. Experimental and Molecular Medicine. 10.1038/emm.2017.246
• (353) Yang, Tian; Jin, Zhaokui; Wang, Zhihao; Zhao, Penghe; Zhao, Bin; Fan, Mingjian; Chen, Lihua; Wang, Tianfu; Su, Bao-Lian; He, Qianjun. Intratumoral high-payload delivery and acid-responsive release of H 2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine. 2018. Applied Materials Today. 10.1016/j.apmt.2018.01.008
• (380) Fransson, Anette E.; Kisiel, Marta; Pirttila, Kristian; Pettersson, Curt; Pierre, Pernilla Videhult; Laurell, Goran F.E. Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig. 2017. Frontiers in Cellular Neuroscience. 10.3389/fncel.2017.00280
• (403) Li, Qiang; Tanaka, Yoshiharu; Miwa, Nobuhiko. Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells in vitro. 2017. Medical Gas Research. 10.4103/2045-9912.208510
• (417) Nakamura, Kyoko; Muraoka, Osamu. Effect of electrolyzed water produced using carbon electrodes on HeLa cell proliferation. 2017. Bioscience Trends. 10.5582/bst.2017.01193
• (451) Yang, Qingxi; Ji, Guangdong; Pan, Rongtao; Zhao, Yinghui; Yan, Peng. Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. 2017. Molecular and Clinical Oncology. 10.3892/mco.2017.1409
• (462) Zhang, Junling; Xue, Xiaolei; Han, Xiaodan; Li, Yuan; Lu, Lu; Li, Deguan; Fan, Saijun. Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical. 2017. Oxidative Medicine and Cellular Longevity. 10.1155/2017/8241678
• (476) Gao, Yunan; Yang, Hongxiao; Fan, Yanbin; Li, Lin; Fang, Jiahui; Yang, Wei. Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis. 2016. Mediators of Inflammation. 10.1155/2016/1320365
• (479) Guo, Jiaming; Zhao, Deyun; Lei, Xiao; Zhao, Hainan; Yang, Yanyong; Zhang, Pei; Liu, Pengfei; Xu, Yang; Zhu, Meizhou; Liu, Hu; Chen, Yuanyuan; Chuai, Yunhai; Li, Bailong; Gao, Fu; Cai, Jianming. Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. 2016. Oxidative Medicine and Cellular Longevity. 10.1155/2016/1947819
• (512) Qin, X.; Yin J.; Li, J.; An, Q.; Wen, J.; Niu, Qiao. Radio-protective effect of hydrogen rich water combined with amifostine in mice. 2016. International Journal of Radiation Research. 10.18869/acadpub.ijrr.14.2.113
• (570) Meng, Xiaoyin; Chen, Hongguang; Wang, Guolin; Yu, Yonghao; Xie, Ke-Liang. Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress. 2015. Experimental and Therapeutic Medicine. 10.3892/etm.2015.2787
• (579) Runtuwene, Joshua; Amitani, Haruka; Amitani, Marie; Asakawa, Akihiro; Cheng, Kai-Chun; Inui, Akio. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. 2015. PeerJ. 10.7717/peerj.859
• (580) Saitoh, Yasukazu; Ikeshima, M.; Kawasaki, N.; Matsumoto, A.; Miwa, Nobuhiko. Transient generation of hydrogen peroxide is responsible for carcinostatic effects of hydrogen combined with platinum nanocolloid, together with increases intracellular ROS, DNA cleavages, and proportion of G2/M-phase. 2015. Free Radical Research. 10.3109/10715762.2015.1131823
• (610) Yuan, Lijuan; Chen, Xiaoping; Qian, Liren; Shen, Jianliang; Cai, Jianming. Administration of Hydrogen-Rich Saline in Mice with Allogeneic Hematopoietic Stem-Cell Transplantation. 2015. Medical Science Monitor. 10.12659/MSM.891338
• (641) Kikkawa, Yayoi S.; Nakagawa, Takayuki; Taniguchi, Mirei; Ito, Juichi. Hydrogen protects auditory hair cells from cisplatin-induced free radicals. 2014. Neuroscience Letters. 10.1016/j.neulet.2014.07.025
• (643) Kunos, Charles A.; Abdallah, Rita R.; Lyons, Janice A. Hydration During Breast Radiotherapy May Lower Skin Toxicity. 2014. Breast Journal. 10.1111/tbj.12348
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