Studies Referencing Hydrogen and Reproductive health in Male and Females

Database:

Primary Topic: Breast/Cervix/Ovaries/Penis/Pregnancy/Testes/Uterus

Secondary Topic: Endometriosis (EMT)/Fungal Infection/Infertility/Ovarian Injury/Preeclampsia (PE)/Premature Ovarian Failure (POF)/Preterm Birth/Testicular Injury (or Any)

Tertiary Topic: Candida Yeast/Erectile Dysfunction/Maternal Immune Activation (MIA)/Ovarian Reserve Function/Ovariectomy/Placental Stress/Sperm Motility/Spermatogenesis/Testicular Injury/Uterine Inflammation (or Any)

Female Reproductive Health

● Ovarian Injury

• Hydrogen can protect the ovaries from ischemia-reperfusion injury caused by adnexal torsion (AT) (477: Gokalp et al 2016).

● Endometriosis

• Hydrogen has been shown to ameliorate endometriosis (484: He et al 2016).

● Cancer

• Hydrogen has shown efficacy as a carcinostatic against
  • breast (208: Kou et al 2019; 229: Qi et al 2019; 256: Zhang et al 2019; 281: Frajese et al 2018; 1057: Wang et al 2020; 1074: Liu et al 2020; 1078: Zhao et al 2018),
  • endometrial (147: Yang et al 2020), cervical (208: Kou et al 2019; 353: Yang et al 2018; 417: Nakamura and Muraoka 2017; 775: Kagawa et al 2012; 1014: Shirahata et al 1998; 1028: Chu et al 2021; 1078: Zhao et al 2018; 1079: Zhou et al 2019),
  • and ovarian (115: Qiao et al 2020; 332: Shang et al 2018) cancers.
• Hydrogen protects against reproductive toxicity caused by both radiotherapy (479: Guo et al 2016) and chemotherapy (specifically Cisplatin treatment (570: Meng et al 2015)).

● Infertility

• Hydrogen can help to maintain fertility by protecting against premature ovarian failure (POF) (483: He et al 2016).

● Pregnancy

• Hydrogen protects against herbicide-induced fetal injury, specifically Nitrofen-induced Congenital Diaphragmatic Hernia (1087: Miura et al 2021).
• Hydrogen has been shown to reduce maternal inflammation, leading to protection from
  • preterm birth (550: Hattori et al 2015; 319: Nakano et al 2018; 571: Nakano et al 2015)
  • and fetal respiratory impairment (550: Hattori et al 2015).
• Hydrogen has been shown to protect against fetal brain injury resulting from
  • maternal hypoxia (854: Liu et al 2011; 654: Mano et al 2014),
  • uterine inflammation (488: Imai et al 2016; 571: Nakano et al 2015),
  • and material immune activation (296: Imai et al 2018; 1170: Usui et al 2022).
• Hydrogen has been shown to alleviate pregnancy-induced gingivitis (333: Shi et al 2018).
• Hydrogen protects against hypertensive disorders complicating pregnancy (HDCP) (480: Guo et al 2016).
• Hydrogen has been shown to ameliorate preeclampsia (522: Ushida et al 2016; 545: Guan et al 2015; 687: Zou and Cheng 2014; 881: Yang et al 2011).
• Hydrogen-rich water has been shown to reduce maternal, and thus placental, dehydration better than pure water (334: Shi et al 2018).

● Candida Yeast Infection

• Hydrogen has been shown to have antifungal efficacy against yeast (Candida albicans) infection (226: Park et al 2019; 577: Pyo, Yoo, and Baek 2015; 234: Song and Lee 2019).

● Ovariectomy

• Hydrogen can protect against ovariectomy-induced osteoporosis (243: Wu et al 2019; 698: Guo et al 2013).

Male Reproductive Health

● Erectile Dysfunction

• Hydrogen can help alleviate Diabetes-induced erectile dysfunction (696: Fan et al 2013).

● Infertility

• Hydrogen can help maintain fertility (572: Nakata et al 2015; 88: Ku et al 2020) by
  • protecting against testicular injury caused by cigarette smoke exposure (539: Chen and Jiang et al 2015; 646: Li et al 2014),
  • ionizing radiation (707: Jiang et al 2013: 760: Chuai et al 2012; 828: Chuai et al 2011),
  • torsion injury (773: Jiang et al 2012; 783: Lee et al 2012),
  • and spinal cord injury (384: Ge et al 2017).

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (570: Meng et al 2015; 477: Gokalp et al 2016; 696: Fan et al 2013; 550: Hattori et al 2015; 488: Imai et al 2016; 654: Mano et al 2014; 522: Ushida et al 2016; 687: Zou and Cheng 2014; 881: Yang et al 2011; 334: Shi et al 2018; 571: Nakano et al 2015; 539: Chen and Jiang et al 2015; 646: Li et al 2014; 707: Jiang et al 2013; 828: Chuai et al 2011; 773: Jiang et al 2012; 783: Lee et al 2012; 698: Guo et al 2013),

increasing the activity of endogenous antioxidant enzymes (570: Meng et al 2015; 477: Gokalp et al 2016; 687: Zou and Cheng 2014; 334: Shi et al 2018; 539: Chen and Jiang et al 2015; 707: Jiang et al 2013; 773: Jiang et al 2012; 484: He et al 2016),

upregulating cellular protection mechanisms (480: Guo et al 2016; 88: Ku et al 2020; 384: Ge et al 2017),

counteracting inflammation and apoptosis (570: Meng et al 2015; 550: Hattori et al 2015; 333: Shi et al 2018; 488: Imai et al 2016; 881: Yang et al 2011; 334: Shi et al 2018; 319: Nakano et al 2018; 571: Nakano et al 2015; 707: Jiang et al 2013; 773: Jiang et al 2012; 783: Lee et al 2012; 384: Ge et al 2017; 243: Wu et al 2019; 698: Guo et al 2013; 1170: Usui et al 2022),

improving immune function (296: Imai et al 2018),

and restoring mitochondrial function (572: Nakata et al 2015).

Literature Cited (numbered as per database):

● (88) Ku, Ja Yoon; Park, Min Jung; Park, Hyun Jun; Park, Nam Cheol; Joo, Bo Sun. Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice. 2020. Chinese Journal of Integrative Medicine. 10.1007/s11655-019-3047-1

● (115) Qiao, Shuang; Wang, Yongjie; Zan, Rui; Wu, Hongliu; Sun, Yu; Peng, Hongzhou; Zhang, Rui; Song, Yang; Ni, Jiahua; Zhang, Shaoxiang; Zhang, Xiaonong. Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor. 2020. ACS Biomaterials Science and Engineering. 10.1021/acsbiomaterials.9b01703

● (147) Yang, Ye; Liu, Ping Yin; Bao, Wei; Chen, Song Jun; Wu, Fang Su; Zhu, Ping Ya. Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. 2020. BMC Cancer. 10.1186/s12885-019-6491-6

● (208) Kou, Zhu; Zhao, Penghe; Wang, Zhihao; Jin, Zhaokui; Chen, Lihua; Su, Bao-Lian; He, Qianjun. Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy. 2019. Journal of Materials Chemistry B. 10.1039/C9TB00338J

● (226) Park, Mi-Jung; Choi, Youn-Hee; Song, Keun-Bae; Kim, Eun-Kyong. Antifungal effects of hydrogen water on the growth of Candida albicans. 2019. Journal of Korean Academy of Oral Health. 10.11149/jkaoh.2019.43.4.173

● (229) Qi, Guohua; Wang, Bo; Song, Xiangfu; Li, Haijuan; Jin, Yongdong. A green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry. 2019. National Science Review. 10.1093/nsr/nwz199

● (234) Song, Young-Gyun; Lee, Sung-Hoon. Efficacy of newly developed denture cleaning device on physical properties of denture material and Candida biofilm. 2019. Journal of Dental Sciences. 10.1016/j.jds.2019.01.011

● (243) Wu, Gang; Pan, Lei; Sun, Jing; Chen, Guimin; Wang, Shaohai. Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation. 2019. Menopause. 10.1097/GME.0000000000001310

● (256) Zhang, Cheng; Zheng, Di-Wei; Li, Chu-Xin; Zou, Mei-Zhen; Yu, Wu-Yang; Liu, Miao-Deng; Peng, Si-Yuan; Zhong, Zhen-Lin; Zhang, Xian-Zheng. Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant tumor. 2019. Biomaterials. 10.1016/j.biomaterials.2019.119472

● (281) Frajese, Giovanni Vanni; Benvenuto, Monica; Mattera, Rosanna; Giampaoli, Saverio; Ambrosin, Elena; Bernardini, Roberta; Giganti, Maria Gabriella; Albonici, Loredana; Dus, Ivan; Manzari, Vittorio; Modesti, Andrea; Mattei, Maurizio; Bei, Roberto. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. 2018. Evidence-Based Complementary and Alternative Medicine. 10.1155/2018/4753507

● (296) Imai, Kenji; Kotani, Tomomi; Tsuda, Hiroyuki; Nakano, Tomoko; Ushida, Takafumi; Iwase, Akira; Nagai, Taku; Toyokuni, Shinya; Suzumura, Akio; Kikkawa, Fumitaka. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model. 2018. Nature Scientific Reports. 10.1038/s41598-018-27626-4

● (319) Nakano, Tomoko; Kotani, Tomomi; Imai, Kenji; Itani, Yukako; Ushida, Takafumi; Tsuda, Hiroyuki; Li, Hua; Iwase, Akira; Toyokuni, Shinya; Kikkawa, Fumitaka. Effect of molecular hydrogen on uterine inflammation during preterm labour. 2018. Biomedical Reports. 10.3892/br.2018.1082

● (332) Shang, Lei; Xie, Fei; Li, Jiala; Zhang, Yating; Liu, Mengyu; Zhao, Pengxiang; Ma, Xuemei; Lebaron, Tyler W. Therapeutic potential of molecular hydrogen in ovarian cancer. 2018. Translational Cancer Research. 10.21037/tcr.2018.07.09

● (333) Shi, Yun-Zhi; Jin, Song; Zheng, Hui-Hu; Qin, Han; Qin, Shu-Cun. Hydrogen rich water attenuates pregnancy gingivitis induced by ligation in SD rats. 2018. Shanghai Journal of Stomatology. 30411118

● (334) Shi, Yun-Zhi; Jin, Song; Qin, Han; Jiang, Heng-Bo; Song, Guo-Hua; Qin, Shu-Cun. Hydrogen-rich water ameliorates rat placental stress induced by water restriction. 2018. Medical Gas Research. 10.4103/2045-9912.241064

● (353) Yang, Tian; Jin, Zhaokui; Wang, Zhihao; Zhao, Penghe; Zhao, Bin; Fan, Mingjian; Chen, Lihua; Wang, Tianfu; Su, Bao-Lian; He, Qianjun. Intratumoral high-payload delivery and acid-responsive release of H 2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine. 2018. Applied Materials Today. 10.1016/j.apmt.2018.01.008

● (384) Ge, Li; Wei, Li-Hua; Du, Chang-Qing; Song, Guo-Hua; Xue, Ya-Zhou; Shi, Hao-Shen; Yang, Ming; Yin, Xin-Xin; Li, Run-Ting; Wang, Xue-Er; Wang, Zhen; Song, Wen-Gang. Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. 2017. Oncotarget. 10.18632/oncotarget.15876

● (417) Nakamura, Kyoko; Muraoka, Osamu. Effect of electrolyzed water produced using carbon electrodes on HeLa cell proliferation. 2017. Bioscience Trends. 10.5582/bst.2017.01193

● (477) Gokalp, Nurcan; Can Basaklar, Abdullah; Sonmez, Kaan; Turkyilmaz, Zafer; Karabulut, Ramazan; Poyraz, Aylar; Gulbahar, Ozlem. Protective Effect of Hydrogen Rich Saline Solution on Experimental Ovarian Ischemia Reperfusion Model in Rats. 2016. Journal of Pediatric Surgery. 10.1016/j.jpedsurg.2016.10.006

● (479) Guo, Jiaming; Zhao, Deyun; Lei, Xiao; Zhao, Hainan; Yang, Yanyong; Zhang, Pei; Liu, Pengfei; Xu, Yang; Zhu, Meizhou; Liu, Hu; Chen, Yuanyuan; Chuai, Yunhai; Li, Bailong; Gao, Fu; Cai, Jianming. Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. 2016. Oxidative Medicine and Cellular Longevity. 10.1155/2016/1947819

● (480) Guo, Li-Li; Guan, Z.; Li, H.; Yang, Xiang. Hydrogen inhibits cytotrophoblast cells apoptosis in hypertensive disorders complicating pregnancy. 2016. Cellular and Molecular Biology. 10.14715/cmb/2016.62.6.11

● (483) He, Xin; Wang, Shu-Yu; Yin, Cheng-Hong; Wang, Tong; Jia, Chan-Wei; Ma, Yan-Min. Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida 3. 2016. Chinese Medical Journal. 10.4103/0366-6999.190668

● (484) He, Y.; Shi, J.Z.; Zhang, R.J.; Zhai, D.X.; Zhang, D.; Yu, C.Q.; Liu, Y.H. Effects of Hydrogen Gas Inhalation on Endometriosis in Rats. 2016. Reproductive Sciences. 10.1177/1933719116655622

● (488) Imai, Kenji; Kotani, Tomomi; Tsuda, Hiroyuki; Mano, Yukio; Nakano, Tomoko; Ushida, Takafumi; Li, Hua; Miki, Rika; Sumigama, Seiji; Iwase, Akira; Hirakawa, Akihiro; Ohno, Kinji; Toyokuni, Shinya; Takeuchi, Hideyuki; Mizuno, Tatsuya; Suzumara, Akio; Kikkawa, Fumitaka. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. 2016. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2015.12.015

● (522) Ushida, Takafumi; Kotani, Tomomi; Tsuda, Hiroyuki; Imai, Kenji; Nakano, Tomoko; Hirako, Shima; Ito, Yumiko; Li, Hua; Mano, Yukio; Wang, Jingwen; Miki, Rika; Yamamoto, Eiko; Iwase, Akira; Bando, Yasuko K.; Hirayama, Masaaki; Ohno, Kinji; Toyokuni, Shinya; Kikkawa, Fumitaka. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. 2016. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2016.10.491

● (539) Chen, Song; Jiang, Wei. Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke. 2015. International Journal of Clinical and Experimental Medicine. 10.7727/wimj.2015.332

● (545) Guan, Zhong; Li, Huai-Fang; Guo, Li-Li; Yang, Xiang. Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. 2015. Archives of Gynecology and Obstetrics. 10.1007/s00404-015-3647-8

● (550) Hattori, Y.; Kotani, T.; Tsuda, H.; Mano, Y.; Tu, L.; Li, H.; Hirako, S.; Ushida, T.; Imai, K.; Nakano, T.; Sato, Y.; Miki, R.; Sumigama, S.; Iwase, A.; Toyokuni, S.; Kikkawa, Fumitaka. Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury. 2015. Free Radical Research. 10.3109/10715762

● (570) Meng, Xiaoyin; Chen, Hongguang; Wang, Guolin; Yu, Yonghao; Xie, Ke-Liang. Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress. 2015. Experimental and Therapeutic Medicine. 10.3892/etm.2015.2787

● (571) Nakano, Tomoko;Kotani, Tomomi; Mano, Yukio; Tsuda, Hiroyuki; Imai, Kenji; Ushida, Takafumi; Li, Hua; Miki, Rika; Sumigama, Seiji; Sato, Yoshiaki; Iwase, Akira; Hirakawa, Akihiro; Asai, Masako; Toyokuni, Shinya; Kikkawa, Fumitaka. Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. 2015. Journal of Clinical Biochemistry and Nutrition. 10.3164/jcbn.15-90

● (572) Nakata, Kumiko; Yamashita, Naoki; Noda, Yoshihiro; Ohsawa, Ikuroh. Stimulation of human damaged sperm motility with hydrogen molecule. 2015. Medical Gas Research. 10.1186/s13618-014-0023-x

● (577) Pyo, Kyung-Ryul; Yoo, Yun Seung; Baek, Dong-Heon. Antifungal effect of electrolyzed hydrogen water on Candida albicans biofilm. 2015. Journal of Dental Rehabilitation and Applied Science. 10.14368/jdras.2015.31.3.212

● (646) Li, Shu; Lu, DanDan; Zhang, Yaling; Zhang, Yi. Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. 2014. Journal of Assisted Reproduction and Genetics. 10.1007/s10815-013-0102-2

● (654) Mano, Yukio; Kotani, Tomomi; Ito, Mikako; Nagai, Taku; Ichinohashi, Yuko; Yamada, Kiyofumi; Ohno, Kinji; Kikkawa, Fumitaka; Toyokuni, Shinya. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. 2014. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2014.01.037

● (687) Zou, Y.F.; Cheng, W.W. Regulative effect of hydrogen on oxidative stress level of placental ischemia-reperfusion cell model of preeclampsia. 2014. Journal of Shanghai Jiaotong University. 10.3969/j.issn.1674-8115.2014.07.007

● (696) Fan, Min; Xu, Xianlin; He, Xiaozhou; Chen, Lujun; Qian, Liren; Liu, Jipu; Qing, Jiandi; Chao, Zhifu; Sun, Xue-Jun. Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. 2013. Journal of Urology. 10.1016/j.juro.2012.12.001

● (698) Guo, Ji-Dong; Li, Li; Shi, Ya-Min; Wang, Hua-Dong; Hou, Shu-Xun. Hydrogen water consumption prevents osteopenia in ovariectomized rats. 2013. British Journal of Pharmacology. 10.1111/bph.12036

● (707) Jiang, Zhitao; Xu, Bo; Yang, Mowen; Li, Zhaozhu; Zhang, Yubo; Jiang, Da-Peng. Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats. 2013. Basic and Clinical Pharmacology and Toxicology. 10.1111/bcpt.12016

● (760) Chuai, Yunhai; Shen, Jianliang; Qian, Liren; Wang, Yicun; Huang, Yuecheng; Gao, Fu; Cui, Jianguo; Ni, Jin; Zhao, Luqian; Liu, Shulin; Sun, Xuejun; Li, Bailong; Cai, Jianming. Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. 2012. Medical Science Monitor. 10.12659/msm.882513

● (773) Jiang, Dapeng; Wu, Dongzhen; Zhang, Yubo; Xu, Bo; Sun, Xuejun; Li, Zhaozhu. Protective Effects of Hydrogen Rich Saline Solution on Experimental Testicular Ischemia-Reperfusion Injury in Rats. 2012. Journal of Urology. 10.1016/j.juro.2012.01.029

● (775) Kagawa, Akio; Katsura, Keishi; Mizumoto, Masayuki; Tagawa, Yutaka; Masiko, Yoichi. Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. 2012. Materials Science Forum. 10.4028/www.scientific.net/MSF.706-709.520

● (783) Lee, Jae-Won; Kim, Jong-In; Lee, Young-Ah; Lee, Dong-Hun; Song, Chang-Seon; Cho, Yoon Ju; Han, Jin Soo. Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. 2012. Journal of Pediatric Surgery. 10.1016/j.jpedsurg.2011.09.035

● (828) Chuai, Yunhai; Gao, Fu; Li, Bailong; Zhao, Luqian; Qian, Liren; Cao, Fei; Wang, Lei; Sun, Xuejun; Cui, Jianguo; Cai, Jianming. Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. 2011. Biochemical Journal. 10.1042/BJ20111786

● (854) Liu, Wenwu; Chen, O.; Chen, C.; Wu, B.; Tang, J.; Zhang, J.H. Protective Effects of Hydrogen on Fetal Brain Injury During Maternal Hypoxia. 2011. Intracerebral Hemorrhage Research. 10.1007/978-3-7091-0693-8_51

● (881) Yang, X.; Guo, L.; Sun, X.; Chen, X.; Tong, X. Protective effects of hydrogen-rich saline in preeclampsia rat model. 2011. Placenta. 10.1016/j.placenta.2011.06.020

● (1014) Shirahata, Sanetaka; Kabayama, S.; Kusumoto, K.; Gotoh, M.; Teruya, K.; Otsubo, K.; Morisawa, J.S.; Hayashi, H.; Katakura, Yoshinori. Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and Regulates Gene Expression of Animal Cells. 1998. New Developments and New Applications in Animal Cell Technology. 10.1007/0-306-46860-3_15

● (1028) Chu, Jing; Gao, Jinghai; Wang, Jing; Li, Lingling; Chen, Guoqiang; Dang, Jianhong; Wang, Zhifeng; Jin, Zhijun; Liu, Xiaojun. Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing. 2021. Oncology Reports. 10.3892/or.2021.8092

● (1057) Wang, Qi; Ji, Yishun; Shi, Jinsheng; Wang, Lili. NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic Cancer Therapy. 2020. ACS Applied Materials & Interfaces. 10.1021/acsami.0c03852

● (1074) Liu, Kun; Ou, Juanfeng; Wang, Shuanghu; Gao, Junbin; Liu, Lu; Ye, Yicheng; Wilson, Daniela A.; Hu, Yunrui; Peng, Fei; Tu, Yingfeng. Magnesium-based micromotors for enhanced active and synergistic hydrogen chemotherapy. 2020. Applied Materials Today. 10.1016/j.apmt.2020.100694

● (1078) Zhao, Penghe; Jin, Zhaokui; Chen, Qian; Yang, Tian; Chen, Danyang; Meng, Jin; Lu, Xifeng; Gu, Zhen; He, Qianjun. Local generation of hydrogen for enhanced photothermal therapy. 2018. Nature Communications. 10.1038/s41467-018-06630-2

● (1079) Zhou, Gaoxin; Wang, Ying Shuai; Jin, Zhaokui; Zhao, Penghe; Zhang, Han; Wen, Yanyuan; He, Qianjun. Porphyrin-Palladium Hydride MOF Nanoparticles for Tumor-Targeted Photoacoustic Imaging-Guided Hydrogenothermal Therapy of Cancer. 2019. Nanoscale Horizons. 10.1039/C9NH00021F

● (1087) Miura, Mayo; Imai, Kenji; Tsuda, Hiroyuki; Miki, Rika; Tano, Sho; Ito, Yumiko; Hirako-Takamura, Shima; Moriyama, Yoshinori; Ushida, Takafumi; Iitani, Yukako; Nakano-Kobayashi, Tomoko; Toyokuni, Shinya; Kajiyama, Hiroaki; Kotani, Tomomi. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia. 2021. International Journal of Molecular Sciences. 10.3390/ijms22179500

● (1170) Usui, Noriyoshi; Matsumoto-Miyai, Kazumasa; Koyama, Yoshihisa; Kobayashi, Yuki; Nakamura, Yukiko; Kobayashi, Hikaru; Shimada, Shoichi. Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent. 2022. Frontiers in Psychiatry. 10.3389/fpsyt.2022.872302