Studies Referencing Hydrogen and Lungs and Nose

Database:

Primary Topic: Lung/Nose

Secondary Topic: Lung Injury/Airway Disease/Asthma/Chronic Lung Disease/Chronic Obstructive Pulmonary Disease (COPD)/ “SARS/COVID”/Tracheal Stenosis/Upper Respiratory Tract Infection/Rhinitis/Rhinosinusitis (or Any)

Tertiary Topic: Acute Lung Injury/Lung Microbiome/Bronchopulmonary Dysplasia/Hypercapnia/Hyperoxia/Drowning/Cigarette Smoke Exposure/Smog Exposure/Wood Smoke Exposure/Interstitial Lung Disease/Dyspnea/Extravascular Lung Water/Ventilator-Induced Lung Injury (or Any)

 

Lung Issues

● Hydrogen has been shown to improve lung issues including

• asthma (37: Zhang et al 2021; 932: Itoh et al 2009; 109: Niu et al 2020; 358: Zhang et al 2018; 117: Qiu et al 2020; 227: Permadani, Mardiyono, and Santjaka 2019; 741: Xiao et al 2013; 194: Huang et al 2019),
• tracheal stenosis (364: Zhou et al 2018),
• bronchopulmonary dysplasia (507: Muramatsu et al 2016),
• chronic obstructive pulmonary disease (COPD) (1055: Su et al 2021; 41: Zheng et al 2021; 269: Chen et al 2018; 105: Ma et al 2020; 136: Wang et al 2020),
• diving-induced hyperoxia (927: Zheng et al 2020),
• fibrosis (379: Dong et al 2017),
• burn-induced (830: Fang et al 2011; 1150: Qin et al 2017)
• and hemorrhagic (220: Meng et al 2019; 223: Moon et al 2019; 558: Kohama et al 2015; 626: Du et al 2014) shock,
• drowning-induced lung injury (473: Diao et al 2016),
• head-injury-induced lung injury (1121: Li et al 2021), endotoxemia-induced lung injury (16: Li et al 2021),
• ischemia-reperfusion injury (939: Mao et al 2009; 1031: Liu et al 2021; 366: Zou et al 2018; 433: Takahashi et al 2017; 784: Li et al 2012; 799: Shi et al 2012; 1091: Zheng et al 2021),
• rheumatoid arthritis-associated interstitial lung disease (238: Terasaki et al 2019),
• viral infection-associated lung injury (i.e. COVID-19) (62: Guan et al 2020; 58: Delgado-Enciso et al 2020; 1107: Singh et al 2021; 1145: Luo et al 2022; 1148: Botek et al 2022),
• airway disease (1105: You et al 2021),
• and sepsis (867: Qiu et al 2011; 240: Wang et al 2019; 368: Audi et al 2017; 565: Liu et al 2015; 786: Liang et al 2012; 249: Yang et al 2019; 521: Tao et al 2016; 1054: Qiu et al 2021; 255: Yu et al 2019; 276: Dong et al 2018; 500: Liu et al 2016; 530: Yu et al 2016; 612: Zhai et al 2015; 618: Zhang, Liu, and Zhang 2015; 716: Liu et al 2013; 811: Xie et al 2012; 561: Li et al 2015; 1035: Chen et al 2021; 1041: Bian et al 2016; 1096: Sun et al 2021; 1108: Du et al 2021; 1151: Li et al 2020; 1154: Fu et al 2020; 1155: Bian et al 2018; 1141: Fan et al 2022; 1167: Shi et al 2022; 1177: Mu et al 2022).

● Hydrogen shows multiple modes of action against environmental pollutants including inhalation of

• wood smoke (540: Chen et al 2015),
• PM 2.5 (181: Feng et al 2019),
• carbon nano/microparticles (1104: Choi et al 2017),
• urban smog (478: Gong et al 2016),
• and cigarette smoke (314: Lu et al 2018; 405: Liu et al 2017; 408: Liu et al 2017; 432: Suzuki et al 2017; 723: Ning et al 2013; 1055: Su et al 2021),
• as well as exposure to pesticides (i.e. Paraquat (96: Li et al 2020; 563: Liu et al 2015; 582: Sato et al 2015; 853: Liu et al 2011; 885: Zhang et al 2011)).

 

Nasal Issues

● Hydrogen has been shown to improve rhinitis (278: Fang et al 2018; 300: Jin et al 2018; 447: Xu et al 2017; 80: Jin et al 2020; 446: Xu et al 2017; 465: Zhao et al 2017; 458: Yu et al 2017).

 

Cancer

● Hydrogen has shown efficacy as a carcinostatic against lung cancer (100: Liu et al 2020; 106: Meng et al 2020; 171: Chen et al 2019; 299: Jiang et al 2018; 343: Wang et al 2018; 961: Ye et al 2008; 996: Shirahata et al 2002; 999: Komatsu et al 2001; 1014: Shirahata et al 1998; 93: Chen et al 2020; 43: Akagi and Baba 2020; 52: Chen et al 2020).

● Hydrogen alleviates chemotherapy-induced tissue damage, including lung fibrosis (specifically Bleomycin treatment (182: Gao et al 2019; 1113: Aokage et al 2021)) and interstitial pneumonia (specifically Gefitinib treatment (237: Terasaki et al 2019)).

● Hydrogen protects against radiation therapy-induced lung damage (875: Terasaki et al 2011).

 

Surgery and Transplantation

● Hydrogen has been shown to effectively prevent morbidities resulting from the transplantation of lung tissue (113: Ozeki et al 2020; 83: Kayawake et al 2020; 230: Saito et al 2019; 357: Zhang et al 2018; 504: Meng et al 2016; 566: Liu et al 2015; 754: Zhou et al 2013; 805: Tanaka et al 2012; 900: Kawamura et al 2010; 288: Haam et al 2018; 548: Haam et al 2015; 657: Noda et al 2014; 846: Kawamura et al 2011; 1091: Zheng et al 2021; 1131: Zhang et al 2019; 1132: Saito et al 2018).

● Hydrogen has been shown to relieve lung tissue injuries resulting from ventilator use (600: Wu et al 2015; 835: Huang et al 2011; 896: Huang et al 2010; 1042: Huang et al 2010).

● Hydrogen has been shown to alleviate tissue injuries resulting from hyperoxia (347: Wu et al 2018; 430: Sun et al 2017; 746: Yao et al 2013; 872: Sun et al 2011; 927: Zheng et al 2010; 315: Lu et al 2018; 709: Kawamura et al 2013).

 

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (358: Zhang et al 2018; 194: Huang et al 2019; 182: Gao et al 2019; 237: Terasaki et al 2019; 875: Terasaki et al 2011; 269: Chen et al 2018; 540: Chen et al 2015; 181: Feng et al 2019; 408: Liu et al 2017; 432: Suzuki et al 2017; 563: Liu et al 2015; 885: Zhang et al 2011; 379: Dong et al 2017; 830: Fang et al 2011; 473: Diao et al 2016; 453: Ying et al 2017; 939: Mao et al 2009; 1031: Liu et al 2021; 249: Yang et al 2019; 255: Yu et al 2019; 530: Yu et al 2016; 612: Zhai et al 2015; 618: Zhang, Liu, and Zhang 2015; 716: Liu et al 2013; 220: Meng et al 2019; 558: Kohama et al 2015; 626: Du et al 2014; 746: Yao et al 2013; 872: Sun et al 2011; 366: Zou et al 2018; 784: Li et al 2012; 799: Shi et al 2012; 230: Saito et al 2019; 504: Meng et al 2016; 566: Liu et al 2015; 754: Zhou et al 2013; 600: Wu et al 2015; 458: Yu et al 2017; 1104: Choi et al 2017; 1105: You et al 2021; 1108: Du et al 2021; 1131: Zhang et al 2019),

increasing the activity of endogenous antioxidant enzymes (358: Zhang et al 2018; 194: Huang et al 2019; 237: Terasaki et al 2019; 540: Chen et al 2015; 96: Li et al 2020; 563: Liu et al 2015; 379: Dong et al 2017; 1031: Liu et al 2021; 249: Yang et al 2019; 255: Yu et al 2019; 530: Yu et al 2016; 612: Zhai et al 2015; 716: Liu et al 2013; 220: Meng et al 2019; 626: Du et al 2014; 746: Yao et al 2013; 366: Zou et al 2018; 784: Li et al 2012; 566: Liu et al 2015; 754: Zhou et al 2013; 846: Kawamura et al 2011; 458: Yu et al 2017; 1105: You et al 2021; 1108: Du et al 2021; 1150: Qin et al 2017),

upregulating cellular protection mechanisms (507: Muramatsu et al 2016; 1055: Su et al 2021; 105: Ma et al 2020; 96: Li et al 2020; 473: Diao et al 2016; 1031: Liu et al 2021; 255: Yu et al 2019; 561: Li et al 2015; 315: Lu et al 2018; 347: Wu et al 2018; 430: Sun et al 2017; 709: Kawamura et al 2013; 288: Haam et al 2018; 357: Zhang et al 2018; 805: Tanaka et al 2012; 835: Huang et al 2011; 1105: You et al 2021; 1108: Du et al 2021; 1151: Li et al 2020; 1155: Bian et al 2018; 1167: Shi et al 2022; 1177: Mu et al 2022),

counteracting inflammation and apoptosis (37: Zhang et al 2021; 358: Zhang et al 2018; 741: Xiao et al 2013; 194: Huang et al 2019; 182: Gao et al 2019; 875: Terasaki et al 2011; 1055: Su et al 2021; 105: Ma et al 2020; 136: Wang et al 2020; 540: Chen et al 2015; 181: Feng et al 2019; 478: Gong et al 2016; 405: Liu et al 2017; 408: Liu et al 2017; 473: Diao et al 2016; 16: Li et al 2021; 453: Ying et al 2017; 939: Mao et al 2009; 238: Terasaki et al 2019; 867: Qiu et al 2011; 240: Wang et al 2019; 565: Liu et al 2015; 786: Liang et al 2012; 255: Yu et al 2019; 530: Yu et al 2016; 612: Zhai et al 2015; 618: Zhang, Liu, and Zhang 2015; 811: Xie et al 2012; 561: Li et al 2015; 220: Meng et al 2019; 223: Moon et al 2019; 558: Kohama et al 2015; 626: Du et al 2014; 347: Wu et al 2018;872: Sun et al 2011; 366: Zou et al 2018; 433: Takahashi et al 2017; 784: Li et al 2012; 799: Shi et al 2012; 1091: Zheng et al 2021; 113: Ozeki et al 2020; 230: Saito et al 2019; 357: Zhang et al 2018; 504: Meng et al 2016; 548: Haam et al 2015; 566: Liu et al 2015; 657: Noda et al 2014; 754: Zhou et al 2013; 900: Kawamura et al 2010; 600: Wu et al 2015; ; 896: Huang et al 2010; 278: Fang et al 2018; 465: Zhao et al 2017; 1096: Sun et al 2021; 1108: Du et al 2021; 1121: Li et al 2021; 1131: Zhang et al 2019; 1151: Li et al 2020; 1154: Fu et al 2020; 1167: Shi et al 2022),

improving immune function (932: Itoh et al 2009; 194: Huang et al 2019; 52: Chen et al 2020; 507: Muramatsu et al 2016; 269: Chen et al 2018; 1054: Qiu et al 2021; 113: Ozeki et al 2020; 447: Xu et al 2017; 446: Xu et al 2017; 1113: Aokage et al 2021),

restoring mitochondrial function (43: Akagi and Baba 2020; 276: Dong et al 2018; 1035: Chen et al 2021; 746: Yao et al 2013; 657: Noda et al 2014),

and regulating the lung microbiome (117: Qiu et al 2020).

 

Literature Cited (numbered as per database):

● (16) Li, Qian; Hu, Liang; Li, Juan; Yu, Pan; Hu, Fan; Wan, Bing; Xu, Miaomiao; Cheng, Huixian; Yu, Wanyou; Jiang, Liping; Shi, Yadan; Li, Jincan; Duan, Manlin; Long, Yun; Liu, Wen-Tao. Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression. 2021. Frontiers in Immunology. 10.3389/fimmu.2021.625957

● (37) Zhang, Jingxi; Feng, Xiumin; Fan, Yunxin; Zhu, Guanglin; Bai, Chong. Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis. 2021. Inflammation Research. 10.1007/s00011-021-01459-w

● (41) Zheng, Ze-Guang; Sun, Wu-Zhuang; Hu, Jie-Ying; Jie, Zhi-Jun; Xu, Jin-Fu; Cao, Jie; Song, Yuan-Lin; Wang, Chang-Hui; Wang, Jing; Zhao, Hui; Guo, Zhong-Liang; Zhong, Nan-Shan. Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial. 2021. Respiratory Research. 10.1186/s12931-021-01740-w

● (43) Akagi, Junji; Baba, Hideo. Hydrogen gas activates coenzyme Q10 to restore exhausted CD8 + T cells, especially PD-1 + Tim3 + terminal CD8 + T cells, leading to better nivolumab outcomes in patients with lung cancer. 2020. Oncology Letters. 10.3892/ol.2020.12121

● (52) Chen, Ji-Bing; Kong, Xiao-Feng; Qian, Wei; Mu, Feng; Lu, Tian-Yu; Lu, You-Yong; Xu, Ke-Cheng. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. 2020. Medical Gas Research. 10.4103/2045-9912.304221

● (58) Delgado-Enciso, Ivan; Paz-Garzia, Juan; Barajas-Saucedo, Carlos E.; Mokay-Ramirez, Karen A.; Meza-Robles, Carmen; Lopez-Flores, Rodrigo; Delgado-Machuca, Marina; Murillo-Zamora, Efren; Toscano-Velazquez, Jose A.; Delgado-Enciso, Josuel; Melnikov, Valery; Walle-Guillen, Mireya; Galvan-Salazar, Hector R.; Dalgado-Enciso, Osiris G.; Cabrera-Licona, Ariana; Guzman-Esquivel, Jose; Montes-Galindo, Daniel A.; Hernandez-Rangel, Alejandra E.; Montes-Diaz, Patricia; Rodriguez-Sanchez, Iram P.; Martinez-Fierro, Margarita L.; Garza-Veloz, Idalia; Tiburcio-Jimenez, Daniel; Zaizar-Fregoso, Sergio A.; Ramirez-Flores, Mario; Gaytan-Sandoval, Gustavo; Martinez-Perez, Carlos R.; Espinoza-Gomez, Francisco; Rojas-Larios, Fabian; Hirsch-Meillon, Michael J.; Barrios-Navarro, Enrique; Oviedo-Rodriguez, Vladimir; Baltazar Rodriguez, Luz M.; Paz-Michel, Brenda A. Patient-Reported Health Outcomes After Treatment of COVID-19 with Nebulized and/or Intravenous Neutral Electrolyzed Saline Combined with Usual Medical Care Versus Usual Medical care alone: A Randomized, Open-Label, Controlled Trial. 2020. Research Square. 10.21203/rs.3.rs-68403/v1

● (62) Guan, Wei-Jie; Wei, Chun-Hua; Chen, Ai-Lan; Sun, Xiao-Cong; Guo, Gaung-Yun; Zou, Xu; Shi, Jin-Dong; Lai, Pei-Zhen; Zheng, Ze-Guang; Zhong, Nan-Shan. Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial. 2020. Journal of Thoracic Disease. 10.21037/jtd-2020-057

● (80) Jin, Ling; Fan, Kai; Zhang, Xi; Zhao, Yihua; Ge, Qin; Wang, Yang; Yu, Shaoqing. Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity. 2020. Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery. 10.13201/j.issn.2096-7993.2020.03.014

● (83) Kayawake, Hidenao; Chen-Yoshikawa, Toyofumi F.; Saito, Masao; Yamagishi, Hiroya; Yoshizawa, Akihiko; Hirano, Shin-Ich; Kurokawa, Ryosuke; Date, Hiroshi. Protective effects of a hydrogen-rich preservation solution in a canine lung transplantation model. 2020. Annals of Thoracic Surgery. 10.1016/j.athoracsur.2020.05.076

● (93) Chen, Ji-Bing; Kong, Xiao-Feng; Mu, Feng; Lu, Tian-Yu; Lu, You-Yong; Xu, Ke-Cheng. Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer. 2020. Medical Gas Research. 10.4103/2045-9912.285560

● (96) Li, Ting; Deng, Shuhao; Lei, Wei; Li, Zhengkun; Wu, Wenjuan; Zhang, Tao; Dong, Zhaoxing. Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression. 2020. Journal of Southern Medical University. 10.12122/j.issn.1673-4254.2020.02.15

● (100) Liu, Leyuan; Yan, Zhenfeng; Wang, Yuanyuan; Meng, Jinghong; Chen, Gang. Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis. 2020. Oncology Letters. 10.3892/ol.2020.11973

● 10.1002/jbt.22467

● (105) Ma, Yiping; Li, Zhu; Zhao, Yalei; Sun, Mo; Sun, Wuzhang; Wang, Jiechao. Effect of hydrogen inhalation on IL-40 and SIgA in a Rat Model of Pulmonary Mucosal Immunity. 2020. bioRxiv. 10.1101/2020.06.29.177345

● (106) Meng, Jinghong; Liu, Leyuan; Wang, Dongchang; Yan, Zhenfeng; Chen, Gang. Hydrogen gas represses the progression of lung cancer via downregulating CD47. 2020. Bioscience Reports. 10.1042/BSR20192761

● (109) Niu, Yinghao; Nie, Qingrong; Dong, Liping; Zhang, Jihua; Liu, Shu Fang; Song, Wei; Wang, Xiaopei; Wu, Guangli; Song, Dongmei. Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch. 2020. Nature Scientific Reports. 10.1038/s41598-020-58999-0

● (113) Ozeki, Naoki; Yamawaki-Ogata, Aika; Narita, Yuji; Mii, Shinji; Ushida, Kaori; Ito, Mikako; Hirano, Shin-Ichi; Kurokawa, Ryosuke; Ohno, Kinji; Usui, Akihiko. Hydrogen water alleviates obliterative airway disease in mice. 2020. General Thoracic and Cardiovascular Surgery. 10.1007/s11748-019-01195-3

● (117) Qiu, Xiangjie; Bajinka, Ousman; Wang, Lili; Wu, Guojin; Tan, Yurong. Effects of high-fat diet on the epithelial-mesenchymal transition of respiratory tract through the glyoxylic acid cycle of pulmonary microbes and the intervention of saturated hydrogen. 2020. Research Square. 10.21203/rs.3.rs-17519/v1

● (136) Wang, Shao-Ting; Bao, Cheng; He, Yudi; Tian, Xinlun; Yang, Yanli; Zhang, Tengyue; Xu, Kai-Feng. Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients. 2020. QJM. 10.1093/qjmed/hcaa164

● (171) Chen, Ji-Bing; Kong, Xiao-Feng; Lv, You-Yong; Qin, Shu-Qun; Sun, Xue-Jun; Mu, Feng; Lu, Tian-Yu; Xu, Ke-Cheng. Real world survey' of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients. 2019. Medical Gas Research. 10.4103/2045-9912.266985

● (181) Feng, Shan; Duan, Erhong; Shi, Xiaojuan; Zhang, Huiran; Li, Haitao; Zhao, Yunxia; Chao, Lingshan; Zhong, Xiaoqian; Zhang, Weiwei; Li, Rongqin; Yan, Xixin. Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor. 2019. International Immunopharmacology. 10.1016/j.intimp.2019.105939

● (182) Gao, Li; Jiang, Dingyuan; Geng, Jing; Dong, Run; Dai, Huaping. Hydrogen inhalation attenuated bleomycin‐induced pulmonary fibrosis by inhibiting TGF‐β1 and relevant oxidative stress and EMT. 2019. Experimental Physiology. 10.1113/EP088028

● (194) Huang, Peikai; Wei, Shushan; Huang, Weihua; Wu, Penghui; Chen, Shuyu; Tao, Ailin; Wang, Hongyu; Liang, Zhenyu; Chen, Rongchang; Yan, Jie; Zhang, Qingling. Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model. 2019. International Immunopharmacology. 10.1016/j.intimp.2019.05.031

● (220) Meng, Xiangzhong; Xu, Hao; Dang, Yangjie; Fan, Yingying; Lv, Miaomiao; Sang, Hanfei; Xu, Lixian. Hyperoxygenated Hydrogen-Rich Solution Suppresses Lung Injury Induced by Hemorrhagic Shock in Rats. 2019. Journal of Surgical Research. 10.1016/j.jss.2019.01.050

● (223) Moon, Duk Hwan; Kang, Du-Young; Haam, Seok Jin; Yumoto, Tetsuya; Tsukahara, Kohei; Yamada, Taihei; Nakao, Atsunori; Lee, Sungsoo. Hydrogen gas inhalation ameliorates lung injury after hemorrhagic shock and resuscitation. 2019. Journal of Thoracic Disease. 10.21037/jtd.2019.03.23

● (227) Permadani, Agista Delima; Mardiyono, Mardiyono; Santjaka, Aris. The combination of alkaline water provision and asthma-induced gymnastics towards peak expiratory flow rate of asthma patients at Surakarta Lung Clinic, Indonesia. 2019. Global Health Management Journal. 10.35898/ghmj-31266

● (230) Saito, Masao; Chen-Yoshikawa, Toyofumi F.; Takahashi, Mamoru; Kayawake, Hidenao; Yokoyama, Yuhei; Kurokawa, Ryosuke; Hirano, Shin-Ichi; Date, Hiroshi. Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation. 2019. Journal of Thoracic and Cardiovascular Surgery. 10.1016/j.jtcvs.2019.09.175

● (237) Terasaki, Yasuhiro; Suzuki, Tetsuya; Tonaki, Kozue; Terasaki, Mika; Kuwahara, Naomi; Ohsiro, Jumi; Iketani, Masumi; Takahashi, Mayumi; Hamanoue, Makoto; Kajimoto, Yusuke; Hattori, Seisuke; Kawaguchi, Hideo; Shimizu, Akira; Ohsawa, Ikuroh. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. 2019. Laboratory Investigation. 10.1038/s41374-019-0187-z

● (238) Terasaki, Yasuhiro; Terasaki, Mika; Kanazawa, Satoshi; Kokuho, Nariaki; Urushiyama, Hirokazu; Kajimoto, Yusuke; Kunugi, Shinobu; Maruyama, Motoyo; Akimoto, Toshio; Miura, Yoko; Igarashi, Tsutomu; Ohsawa, Ikuroh; Shimizu, Akira. Effect of H 2 treatment in a mouse model of rheumatoid arthritis-associated interstitial lung disease. 2019. Journal of Cellular and Molecular Medicine. 10.1111/jcmm.14603

● (240) Wang, Yong; Zhang, Jinghua; Bo, Jinsong; Wang, Xuefen; Zhu, Jingnan. Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice. 2019. Experimental Biology and Medicine. 10.1177/1535370219847941

● (249) Yang, Man; Yu, Yang; Xie, Keliang; Yu, Yong-Hao. Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with Nrf2/HO-1/HMGB1 pathway. 2019. Chinese Critical Care Medicine. 10.3760/cma.j.issn.2095-4352.2019.07.013

● (255) Yu, Yang; Yang, Yongyan; Yang, Man; Wang, Chunyan; Xie, Keliang; Yu, Yong-Hao. Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway. 2019. International Immunopharmacology. 10.1016/j.intimp.2019.01.022

● (269) Chen, Meihong; Zhang, Jie; Chen, Yun; Qiu, Yan; Luo, Zi; Zhao, Sixia; Du, Lei; Tian, Dongbo. Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses. 2018. Nature Scientific Reports. 10.1038/s41598-018-26335-2

● (276) Dong, Aili; Yu, Yang; Wang, Yanyan; Li, Can; Chen, Hongguang; Bian, Yingxue; Zhang, Peng; Zhao, Yungang; Yu, Yonghao; Xie, Ke-Liang. Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics. 2018. International Immunopharmacology. 10.1016/j.intimp.2018.10.012

● (278) Fang, Shengjian; Li, Xinqian; Wei, Xian; Zhang, Yu; Ma, Zhaoxin; Wei, Youzhen; Wang, Weihua. Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis. 2018. Experimental and Therapeutic Medicine. 10.3892/etm.2018.6880

● (288) Haam, Seokjin; Lee, Jin Gu; Paik, Hyo Chae; Suk, Park Moo; Lim, Beom Jin. Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death. 2018. Journal of Heart and Lung Transplantation. 10.1016/j.healun.2018.06.007

● (299) Jiang, Yu; Liu, Gang; Zhang, Li; Cheng, Sheng; Luo, Chun; Liao, Yang; Guo, Shuliang. Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. 2018. Molecular Medicine Reports. 10.3892/mmr.2018.9168

● (300) Jin, J.; Yu, S.Q.; Zhang, X.; Ge, Q.; Zhang, X.L.; Wang, Y.; Qin, M.L. Clinical study of hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis. 2018. Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery. 10.13201/j.issn.1001-1781.2018.07.004

● (314) Lu, Wenju; Li, Defu; Hu, Jieying; Mei, Huijun; Shu, Jiaze; Long, Zhen; Yuan, Liang; Li, Difei; Guan, Ruijuan; Li, Yuanyuan; Xu, Jingyi; Wang, Tao; Yao, Hongwei; Zhong, Nanshan; Zheng, Zeguang. Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice. 2018. Journal of Thoracic Disease. 10.21037/jtd.2018.05.93

● (315) Lu, Xue; Wang, Chao; Wu, Dan; Zhang, Chao; Xiao, Changxue; Xu, Feng. Quantitative proteomics reveals the mechanisms of hydrogen-conferred protection against hyperoxia-induced injury in type II alveolar epithelial cells. 2018. Experimental Lung Research. 10.1080/01902148.2019.1601296

● (343) Wang, Dongchang; Wang, Lifei; Zhang, Yu; Zhao, Yunxia; Chen, Gang. Hydrogen gas inhibits lung cancer progression through targeting SMC3. 2018. Biomedicine and Pharmacotherapy. 10.1016/j.biopha.2018.05.055

● (347) Wu, Dan; Liang, Mulin; Dang, Hongxing; Fang, Fang; Xu, Feng; Liu, Chengjun. Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. 2018. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2017.11.193

● (357) Zhang, Guangchao; Li, Zhe; Meng, Chao; Kang, Jiyu; Zhang, Mengdi; Ma, Liangjuan; Zhou, Huacheng. The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period. 2018. Transplantation. 10.1097/TP.0000000000002276

● (358) Zhang, Ning; Deng, Changwen; Zhang, Xingxing; Zhang, Jingxi; Bai, Chong. Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice. 2018. Asthma Research and Practice. 10.1186/s40733-018-0040-y

● (364) Zhou, Zi-Qing; Zhong, Chang-Hao; Su, Zhu-Quan; Li, Ziao-Ying; Chen, Yu; Chen, Xiao-Bo; Tang, Chun-Li; Zhou, Lu-Qian; Li, Shi-Yue. Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis. 2018. Respiration. 10.1159/000492031

● (366) Zou, Run; Wang, Mao-Hua; Chen, Ye; Fan, xin; Yang, Bo; Du, Juan; Wang, Xiao-Bin; Liu, Ke-Xian; Zhou, Jun. Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 In Rats. 2018. Shock. 10.1097/SHK.0000000000001194

● (368) Audi, Said H.; Jacobs, Elizabeth R.; Zhang, Xiao; Camara, Amadou K.S.; Zhao, Ming; Medhora, Meetha M.; Rizzo, Benjamin; Clough, Anne V. Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury Can be Tracked in vivo Using Molecular Imaging. 2017. Shock. 10.1097/SHK.0000000000000872

● (379) Dong, Wen-Wen; Zhang, Yun-Qian; Zhu, Xiao-Yan; Mao, Yan-Fei; Sun, Xue-Jun; Liu, Yu-Jian; Jiang, Lai. Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis. 2017. Medican Science Monitor. 10.12659/MSM.900452

● (405) Liu, Xiaoyu; Ma, Cuiqing; Wang, Xiaoyu; Wang, Wenjing; Li, Zhu; Wang, Xiansheng; Wang, Pengyu; Sun, Wuzhuang; Xue, Baojian. Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. 2017. International Journal of Chronic Obstructive Pulmonary Disease. 10.2147/COPD.S124547

● (408) Liu, Zibing; Geng, Wenye; Jiang, Chuanwei; Zhao, Shujun; Liu, Yong; Zhang, Ying; Qin, Shucun; Li, Chenxu; Zhang, Xinfang; Si, Yanhong. Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats. 2017. Experimental Biology and Medicine. 10.1177/1535370217725249

● (430) Sun, Qiang; Han, Wenjie; Hu, Huijun; Fan, Danfeng; Li, Yanbo; Zhang, Yu; Lv, Yan; Li, Mingxin; Pan, Shu-Yi. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. 2017. Free Radical Research. 10.1080/10715762.2017.1351027

● (432) Suzuki, Yohei; Sato, Tadashi; Sugimoto, Masataka; Baskoro, Hario; Karasutani, Keiko; Mitsui, Aki; Nurwidya, Fariz; Arano, Naoko; Kodama, Yuzo; Hirano, Shin-Ichi; Ishigami, Akihito; Seyama, Kuniaki; Takahashi, Kazuhisa. Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. 2017. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2017.08.035

● (433) Takahashi, Mamoru; Chen-Yoshikawa, Toyofumi F.; Saito, Masao; Tanaka, Satona; Miyamoto, Ei; Ohata, Keiji; Kondo, Takeshi; Motoyama, Hideki; hijiya, Kyoko; Aoyama, Akihiro; Date, Hiroshi. Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury. 2017. European Journal of Cardio-Thoracic Surgery. 10.1093/ejcts/ezw342

● (446) Xu, Feifei; Yu, S.Q.; Zhao, C.L.; Che, N.; Jin, L.; Wang, Q.L.; Ge, Rongming. Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model. 2017. Chinese Journal of Otorhinolaryngology Head and Neck Surgery. 10.3760/cma.j.issn.1673-0860.2017.07.006

● (447) Xu, Feifei; Yu, Shaoqing; Qin, Mali; Mao, Yong; Jin, Ling; Che, Na; Liu, Shuangxi; Ge, Rongming. Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs. 2017. Inflammation. 10.1007/s10753-017-0666-6

● (453) Ying, Youguo; Xu, Haizhou; Yao, Min; Qin, Zonghe. Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. 2017. Journal of Orthopaedic Surgery and Research. 10.1186/s13018-017-0633-9

● (458) Yu, Shaoqing; Zhao, Chuanliang; Che, Na; Jing, Lin; Ge, Rongming. Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress. 2017. Journal of Inflammation. 10.1186/s12950-016-0148-x

● (465) Zhao, C.; Yu, S.; Li, J.; Xu, W.; Ge, R. Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model. 2017. Allergologia et Immunopathologia. 10.1016/j.aller.2016.10.007

● (473) Diao, Mengyuan; Zhang, Sheng; Wu, Lifeng; Huan, Le; Huang, Fenglou; Cui, Yunliang; Lin, Zhaofen. Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits. 2016. Inflammation. 10.1007/s10753-016-0440-1

● (478) Gong, Z.J.; Guan, J.T.; Ren, X.Z.; Meng, D.Y.; Zhang, H.R.; Wang, B.L.; Yan, X.X. Protective effect of hydrogen on the lung of sanitation workers exposed to haze. 2016. Chinese Journal of Tuberculosis and Respiratory Diseases. 10.3760/cma.j.issn.1001-0939.2016.12.003

● (500) Liu, L.D.; Wu, X.Y.; Tao, B.D.; Wang, N.; Zhang, J. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. 2016. Genetics and Molecular Research. 10.4238/gmr.15016050

● (504) Meng, Chao; Ma, Liangjuan; Niu, Li; Cui, Xiaoguang; Liu, Jinfeng; Kang, Jiyu; Liu, Rongfang; Xing, Jingchun; Jiang, Changlin; Zhou, Huacheng. Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. 2016. Life Sciences. 10.1016/j.lfs.2016.03.015

● (507) Muramatsu, Yukako; Ito, Mikako; Oshima, Takahiro; Kojima, Seiji; Ohno, Kinji. Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats. 2016. Pediatric Pulmonology. 10.1002/ppul.23386

● (521) Tao, Bingdong; Liu, Lidan; Wang, Ni; Wang, Wei; Jiang, Jingjing; Zhang, Jin. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. 2016. Journal of Surgical Research. 10.1016/j.jss.2016.01.009

● (530) Yu, Yang; Zhang, Hongtao; Liu, Liagling; Sun, Zhe; Liang, Yu. Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice. 2016. Chinese Critical Care Medicine. 10.3760/cma.j.issn.2095-4352.2016.05.005

● (540) Chen, Xing; Liu, Qi; Wang, Dawei; Feng, Shihai; Zhao, Yongjian; Shi, Yun; Liu, Qun. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. 2015. Oxidative Medicine and Cellular Longevity. 10.1155/2015/106836

● (548) Haam, Seokjin; Lee, Sungsoo; Paik, Hyo Chae; Park, Moo Suk; Song, Joo Han; Lim, Beom Jin; Nakao, Atsunori. The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death. 2015. European Journal of Cardio-Thoracic Surgery. 10.1093/ejcts/ezv057

● (558) Kohama, Keisuke; Yamashita, Hayato; Aoyama-Ishikawa, Michiko; Takahashi, Toru; Billiar, Timothy R.; Nishimura, Takeshi; Kotani, Joji; Nakao, Atsunori. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. 2015. Surgery. 10.1016/j.surg.2015.03.038

● (561) Li, Yuan; Xie, Keliang; Chen, Hongguang; Wang, Guolin; Yu, Yong-Hao. Hydrogen gas inhibits high mobility group box 1 release in septic mice by up-regulation of heme oxygenase-1. 2015. Journal of Surgical Research. 10.1016/j.jss.2015.02.042

● (563) Liu, Gang; Song, Dongmei; Jiang, Yu; Ge, Yun. Effect of hydrogen-saline on lung injury and heme oxygenase-1 expression in the lung tissue of acute paraquat-intoxicated mice. 2015. Chinese Journal of Industrial Hygiene and Occupational Diseases. 26653223

● (565) Liu, Huiying; Liang, Xiaojun; Wang, Dadong; Zhang, Hongquan; Liu, Lingling; Chen, Hongguang; Li, Yuan; Duan, Qing; Xie, Ke-Liang. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. 2015. Shock. 10.1097/SHK.0000000000000316

● (566) Liu, Rongfang; Fang, Xianhai; Meng, Chao; Xing, Jingchun; Liu, Jinfeng; Yang, Wanchao; Li, Wenzhi; Zhou, Huacheng. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. 2015. Experimental Biology and Medicine. 10.1177/1535370214563895

● (582) Sato, Chie; Kamijo, Yoshito; Yoshimura, Kuniko; Inagaki, Taito; Yamaya, Tatsuhiro; Asakuma, Sadataka; Majima, Masataka; Asari, Yasushi. Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. 2015. Kitasato Medical Journal. https://www.kitasato-u.ac.jp/ktms/kaishi/pdf/KMJ45-1/KMJ45-1p009-016.pdf

● (600) Wu, Qifei; Zhang, Jingyao; Wan, Yong; Song, Sidong; Zhang, Yong; Zhang, Guangjian; Liu, Chang; Fu, Junke. Hydrogen water alleviates lung injury induced by one-lung ventilation. 2015. Journal of Surgical Research. 10.1016/j.jss.2015.06.017

● (612) Zhai, Yu; Zhou, Xiaohong; Dai, Qingchun; Fan, Yamin; Huang, Xinli. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. 2015. Experimental and Molecular Pathology. 10.1016/j.yexmp.2015.03.005

● (618) Zhang, Yan; Liu, Yiming; Zhang, Jin. Saturated hydrogen saline attenuates lps-induced lung disfuction. 2015. Journal of Surgical Research. 10.1016/j.jss.2015.04.055

● (626) Du, Zunmin; Jia, Haipeng; Liu, Jing; Zhao, Xiaomin; Xu, Wei. Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. 2014. Journal of Surgical Research. 10.1016/j.jss.2014.06.051

● (657) Noda, Kentaro; Shigemura, Norihisa; Tanaka, Yugo; Bhama, Jay; D'Cunha, Jonathan; Kobayashi, Hirosuke; Luketich, James; Bermudez, Christian. Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats. 2014. Transplantation. 10.1097/TP.0000000000000254

● (709) Kawamura, Tomohiro; Wakabayashi, Nobunao; Shigemura, Norihisa; Huang, Chien-Sheng; Masutani, Kosuke; Tanaka, Yugo; Noda, Kentaro; Peng, Ximei; Takahashi, Toru; Billiar, Timothy R.; Okumura, Meinoshin; Toyoda, Yoshiya; Kensler, Thomas W.; Nakao, Atsunori. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway. 2013. AJP Lung Cellular and Molecular Physiology. 10.1152/ajplung.00164.2012

● (716) Liu, Wei; Shan, Li-Ping; Dong, Xue-Song; Liu, Xiao-Wei; Ma, Tao; Liu, Zhi. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. 2013. World Journal of Gastroenterology. 10.3748/wjg.v19.i4.492

● (723) Ning, Yunye; Shang, Yan; Huang, Haidong; Zhang, Jingxi; Dong, Yuchao; Xu, Wujian; Li, Qian. Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats. 2013. PLoS One. 10.1371/journal.pone.0083429

● (741) Xiao, M.; Zhu, T.; Wang, T.; Wen, F.Q. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. 2013. European Review for Medical and Pharmacological Sciences. 23661516

● (746) Yao, Lan; Xu, Feng; Luo, Chong; Yu, Pan; Dong, Xinxin; Sun, Xuejun; Liu, Chengjun. Protective effect of hydrogen against hyperoxia-induced type II alveolar epithelial cell injury. 2013. Journal of Southern Medical University. 23443770

● (754) Zhou, Huacheng; Fu, Zhijie; Wei, Yuting; Liu, Jinfeng; Cui, Xiaoguang; Yang, Wanchao; Ding, Wengang; Pan, Peng; Li, Wenzhi. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. 2013. Journal of Heart and Lung Transplantation. 10.1016/j.healun.2012.11.007

● (784) Li, Hui; Zhou, Ronghua; Liu, Jin; Li, Qian; Zhang, Jingyu; Mu, Jinglan; Sun, Xue-Jun. Hydrogen-Rich Saline Attenuates Lung Ischemia-Reperfusion Injury in Rabbits. 2012. Journal of Surgical Research. 10.1016/j.jss.2011.10.001

● (786) Liang, Canxin; Liu, Xinwei; Liu, Ling; He, Dongwei. Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury. 2012. Journal of Southern Medical University. 22931625

● (799) Shi, Jianxin; Yao, Feng; Zhong, Chenxi; Pan, Xufeng; Yang, Yu; Lin, Qiang. Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. 2012. Heart, Lung, and Circulation. 10.1016/j.hlc.2012.05.782

● (805) Tanaka, Yugo; Shigemura, Norihida; Kawamura, Tomohiro; Noda, Kentaro; Isse, Kumiko; Stolz, Donna Beer; Billiar, Timothy R.; Toyoda, Yoshita; Bermudez, Christian A.; Lyons-Weiler, James; Nakao, Atsunori. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. 2012. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2012.08.005

● (811) Xie, Ke-Liang; Yu, Yonghao; Huang, Yi; Zheng, Lina; Li, Lipeng; Chen, Hongguang; Han, Huanzhi; Hou, Lichao; Gong, Gu; Wang, Guo-Lin. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. 2012. Shock. 10.1097/SHK.0b013e31824ddc81

● (830) Fang, Yong; Fu, Xiu-Jun; Gu, Chuan; Xu, Peng; Wang, Ying; Yu, Wei-Rong; Sun, Qiang; Sun, Xue-Jun; Yao, Min. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. 2011. Journal of Burn Care and Research. 10.1097/BCR.0b013e318217f84f

● (835) Huang, Chien-Sheng; Kawamura, Tomohiro; Peng, Ximei; Tochigi, Naobumi; Shigemura, Norhisa; Billiar, Timothy R.; Nakao, Atsunori; Toyoda, Yoshiya. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. 2011. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2011.04.008

● (846) Kawamura, Tomohiro; Huang, Chien Sheng; Peng, Ximei; Masutani, Kosuke; Shigemura, Norihisa; Billiar, Timothy R.; Okumura, Meinoshin; Toyoda, Yoshiya; Nakao, Atsunori. The effect of donor treatment with hydrogen on lung allograft function in rats. 2011. Surgery. 10.1016/j.surg.2011.05.019

● (853) Liu, Shulin; Liu, Kan; Sun, Qiang; Liu, Wenwu; Xu, Weigang; Denoble, Petar; Tao, Hengyi; Sun, Xue-Jun. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. 2011. Journal of Biomedicine and Biotechnology. 10.1155/2011/305086

● (867) Qiu, Xiaochen; Li, Hengyu; Tang, Hongtai; Jin, Yichao; Li, Wuquan; Sun, Yu; Feng, Ping; Sun, Xuejun; Xia, Zhao-Fan. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. 2011. International Immunopharmacology. 10.1016/j.intimp.2011.09.007

● (872) Sun, Qiang; Cai, Jianmei; Liu, Shulin; Liu, Yun; Xu, Weigang; Tao, Hengyi; Sun, Xue-Jun. Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. 2011. Journal of Surgical Research. 10.1016/j.jss.2010.09.024

● (875) Terasaki, Yasuhiro; Ohsawa, Ikuroh; Terasaki, Mika; Takahashi, Mikiko; Kunugi, Shinobu; Dedong, Kang; Urushiyama, Hirokazu; Amenomori, Shunsuke; Kaneko-Togashi, Mayuko; Kuwahara, Naomi; Ishikawa, Arimi; Kamimura, Naomi; Ohta, Shigeo; Fukuda, Yuh. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. 2011. American Journal of Physiology: Lung, Cellular, and Molecular Physiology. 10.1152/ajplung.00008.2011

● (885) Zhang, Hui-Li; Liu, Yuan-Fei; Luo, Xu-Rui; Tan, Wei-Hua; Huang, Liang. Saturated hydrogen saline protects rats from acute lung injury induced by paraquat. 2011. World Journal of Emergency Medicine. 10.5847/wjem.j.1920-8642.2011.02.013

● (896) Huang, Chien-Sheng; Kawamura, Tomohiro; Lee, Sungsoo; Tochigi, Naobumi; Shigemura, Norihisa; Buchholz, Bettina M.; Kloke, John D.; Billiar, Timothy R.; Toyoda, Yoshiya; Nakao, Atsunori. Hydrogen inhalation ameliorates ventilator-induced lung injury. 2010. Critical Care. 10.1186/cc9389

● (900) Kawamura, Tomohiro; Huang, Chien-Sheng; Tochigi, Naobumi; Lee, Sungsoo; Shigemura, Norihisa; Billiar, Timothy R.; Okumura, Meinoshin; Nakao, Atsunori; Toyoda, Yoshiya. Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. 2010. Transplantation. 10.1097/TP.0b013e3181fe1357

● (927) Zheng, Juan; Liu, Kan; Kang, Zhimin; Cai, Jianmei; Liu, Wenwu; Xu, Weigang; Li, Runping; Tao, Hengyi; Zhang, John H.; Sun, Xue-Jun. Saturated hydrogen saline protects the lung against oxygen toxicity. 2010. Undersea and Hyperbaric Medicine. 20568549

● (932) Itoh, Tomohiro; Fujita, Yasunori; Ito, Mikako; Masuda, Akio; Ohno, Kinji; Ichihara, Masatoshi; Kojima, Toshio; Nozawa, Yoshinori; Ito, Masafumi. Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast cells. 2009. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2009.09.047

● (939) Mao, Yan-Fei; Zheng, Xing-Feng; Cai, Jian-Mei; You, Xin-Min; Deng, Xiao-Meng; Zhang, John H.l Jiang, Lei; Sun, Xue-Jun. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. 2009. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2009.02.105

● (961) Ye, Jun; Li, Yuping; Hamasaki, Takeki; Nakamichi, Noboru; Komatsu, Takaaki; Kashiwagi, Taichi; Teruya, Kiichiro; Nishikawa, Ryuhei; Kawahara, Takeshi; Osada, Kazuhiro; Toh, Kazuko; Abe, Masumi; Tian, Huaize; Kabayama, Shigeru; Otsubo, Kazumichi; Morisawa, Shinkatsu; Katakura, Yoshinori; Shirahata, Sanetaka. Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. 2008. Biological and Pharmaceutical Bulletin. 10.1248/bpb.31.19

● (996) Shirahata, Sanetaka; Murakami, En; Kusumoto, Ken-Ichi; Yamashita, Makiko; Oda, Masaaki; Temya, Kiichiro; Kabayama, Shigeru; Otsubo, Kazumichi; Morisawa, Shinkatsu; Hayashi, Hidemitsu; Katakura, Yoshinori. Telomere Shortening in Cancer Cells by Electrolyzed-Reduced Water. 2002. Animal Cell Technology: Challenges for the 21st Century. 10.1007/0-306-46869-7_62

● (999) Komatsu, Takaaki; Kabayama, Shigeru; Hayashida, Akira; Nogami, Hirofuma; Teruya, Kiichiro; Katakura, Yoshinori; Otsubo, Kazumiti; Morisawa, Shinkatsu; Shirahata, Sanetaka. Suppressive Effect of Electrolyzed-Reduced Water on the Growth of Cancer Cells and Microorganisms. 2001. Animal Cell Technology: From Target to Market. 10.1007/978-94-010-0369-8_50

● (1014) Shirahata, Sanetaka; Kabayama, S.; Kusumoto, K.; Gotoh, M.; Teruya, K.; Otsubo, K.; Morisawa, J.S.; Hayashi, H.; Katakura, Yoshinori. Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and Regulates Gene Expression of Animal Cells. 1998. New Developments and New Applications in Animal Cell Technology. 10.1007/0-306-46860-3_15

● (1031) Liu, Ling; Yang, Chao; Qiu, Tingting; Shen, Xin; Liu, Boyan; Qi, Xufeng; Song, Guohua. Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice. 2021. Life Sciences. 10.1016/j.lfs.2021.119659

● (1035) Chen, Hongguang; Lin, Huaying; Dong, Beibei; Wang, Yaoqi; Yu, Yonghao; Xie, Keliang. Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy. 2021. Inflammation Research. 10.1007/s00011-021-01481-y

● (1041) Bian, Y.; Qin, C.; Xie, K.; Yu, Y.; Yu, Y. Abstract PR087: Quantitative Itraq-Coupled Lc-Ms/Ms Proteomics Reveals the Mechanism of Hydrogen Gas Protecting Mice Against Acute Lung Injury Caused By Sepsis. 2016. Anesthesia and Analgesia. 10.1213/01.ane.0000492493.42566.1e

● (1042) Huang, Chien-Sheng; Nakao, Atsunori; Lee, Songsoo; Wang, Zhiliang; Shigemura, Norohisa; Billiar, Timothy R.; Luketich, James; Toyoda, Yoshiya. Abstract B95: Hydrogen Gas Inhalation Attenuates Ventilator-Induced Lung Injury In Mice. 2010. American Thoracic Society International Conference. 10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A3751

● (1054) Qiu, Peng; Liu, Yang; Chen, Keyan; Dong, Youjing; Liu, Shiqing; Zhang, Jin. Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats. 2021. Annals of Translational Medicine. 10.21037/atm-21-2489

● (1055) Su, Jing-Chao; Zhang, Yi; Cheng, Chen; Zhu, Yi-Nan; Ye, Yu-Meng; Sun, Yong-Kang; Xiang, Shui-Ying; Wang, Yuan; Liu, Zi-Bing; Zhang, Xin-Fang. Hydrogen regulates the M1/M2 polarization of alveolar macrophages in a rat model of chronic obstructive pulmonary disease. 2021. Experimental Lung Research. 10.1080/01902148.2021.1919788

● (1091) Zheng, Panpan; Kang, Jiyu; Xing, Entong; Zheng, Bin; Wang, Xueyao; Zhou, Huacheng. Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats. 2021. Frontiers in Physiology. 10.3389/fphys.2021.699344

● (1096) Sun, Ruiqiang; Zhao, Nan; Wang, Yuzun; Su, Yanchao; Zhang, Jiayan; Wang, Yaoqi; Yu, Yonghao; Wang, Guolin; Wang, Zhen; Xie, Keliang. High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice. 2021. International Immunopharmacology. 10.1016/j.intimp.2021.108198

● (1104) Choi, J.; Suk, An E.; Ban, Y.H.; Woom, Seo D.; Kim, T.S.; Lee, S.P.; Lin, Y.; Choi, E.K.; Kim, Y.B. Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity. 2017. Journal of Biomedical Research. 10.7555/jbr.32.20170066

Thuy Trinh; Rahman, Md Habibur; Sung, Jaeyong; Kwon, Huang-Un; Lee, So-Yeon; Kim, Cheol-Su; Lee, Kyu-Jae. Antioxidant Properties of Hydrogen Gas Attenuates Oxidative Stress in Airway Epithelial Cells. 2021. Molecules. 10.3390/molecules26216375

● (1107) Singh, Ram B.; Halabi, Ghazi; Fatima, Ghizal; Rai, Richa H.; Tarnava, Alexander T.; LeBaron, Tyler W. Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID-19 patient. 2021. Clinical Case Reports. 10.1002/ccr3.5039

● (1108) Du, Junfeng; Li, Jingwen; Li, Rongqin; Yan, Xixin. High concentration of hydrogen ameliorates lipopolysaccharide-induced acute lung injury in a sirt1-dependent manner. 2021. Respiratory Physiology & Neurobiology. 10.1016/j.resp.2021.103808

● (1113) Aokage, Toshiyuki; Seya, Mizuki; Hirayama, Takahiro; Nojima, Tsuyoshi; Iketani, Masumi; Ishikawa, Michiko; Terasaki, Yasuhiro; Taniguchi, Akihiko; Miyahara, Nobuaki; Nakao, Atsunori; Ohsawa, Ikuroh; Naito, Hiromichi. The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury. 2021. BMC Pulmonary Medicine. 10.1186/s12890-021-01712-2

● (1121) Li, Ting-Ting; Sun, Tian; Wang, Yue-Zhen; Wan, Qiang; Li, Wen-Zhi; Yang, Wan-Chao. Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis. 2021. European Journal of Pharmacology. 10.1016/j.ejphar.2021.174664

● (1131) Zhang, Jiahang; Zhou, Huacheng; Liu, Jinfeng; Meng, Chao; Deng, Lin; Li, Wenzhi. Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death. 2019. Microvascular Research. 10.1016/j.mvr.2019.103885

● (1132) Saito, M.; Chen-Yoshikawa, T.; Hirano, S.; Kayawake, H.; Ueda, S.; Tokuno, J.; Yamagishi, H.; Gochi, F.; Okabe, R.; Takahagi, A.; Motoyama, H.; Hamaji, M.; Aoyama, A.; Date, H. Abstract 556: Protective Effect of a Hydrogen-Rich Preservation Solution During Cold Ischemia in Rat Lung Transplantation. 2018. Journal of Heart and Lung Transplantation. 10.1016/j.healun.2018.01.559

● (1141) Fan, Yingying; Wang, Jian; Feng, Zhihui; Cao, Ke; Liu, Jiankang; Xu, Hao. Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through mediating NF-κB/NLRP3 signaling pathway in C57BL/6 mice. 2022. Environmental Toxicology. 10.1002/tox.23507

● (1145) Luo, Peng; Ding, Yuanfang; He, Yuan; Chen, Dafeng; He, Qing; Huang, Zufeng; Huang, Shian; Lei, Wei. Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: A retrospective study of medical records. 2022. Medicine. 10.1097/MD.0000000000027759

● (1148) Botek, Michal; Krejci, Jakub; Valenta, Michal; McKune, Andrew; Sladeckova, Barbora; Konecny, Petr; Klimesova, Iva; Pastucha, Dalibor. Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation. 2022. International Journal of Environmental Research and Public Health. 10.3390/ijerph19041992

● (1150) Qin, C.; Bian, Y.X.; Feng, T.T.; Zhang, J.H.; Yu, Y.H. Effects of hydrogen on the lung damage of mice at early stage of severe burn. 2017. Chinese Journal of Burns. 10.3760/cma.j.issn.1009-2587.2017.11.005

● (1151) Li,Yuan; Chen, Hongguang; Shu, Ruichen; Zhang, Xiaobei; Yu, Yonghao; Liu, Xiaofeng; Xu, Kuibin. Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition. 2020. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2019.11.101

● (1154) Fu, Zhiling; Zhang, Ze; Wu, Xiuying; Zhang, Jin. Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway. 2020. BioMed Research International. 10.1155/2020/9121894

● (1155) Bian, Yingxue; Qin, Chao; Xin, Yuchang; Yu, Yang; Chen, Hongguang; Wang, Guolin; Xie, Keliang; Yu, Yonghao. Itraq-Based Quantitative Proteomic Analysis of Lungs in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment. 2018. Shock. 10.1097/SHK.0000000000000927

● (1167) Shi, Xuan; Zhu, Lina; Wang, Sheng; Zhu, Wanli; Li, Quanfu; Wei, Juan; Feng, Di; Liu, Meiyun; Chen, Yuanli; Sun, Xuejun; Lu, Hongtao; Lv, Xin. Magnesium Hydride Ameliorates Endotoxin-Induced Acute Respiratory Distress Syndrome by Inhibiting Inflammation, Oxidative Stress, and Cell Apoptosis. 2022. Oxidative Medicine and Cellular Longevity. 10.1155/2022/5918954

● (1177) Mu, Qingjie; Lv, Kaixuan; Yu, Jielun; Chu, Shangmin; Zhang, Lichun; Kong, Lingyu; Zhang, Linlin; Tian, Yan; Jia, Xiaopeng; Liu, Benhong; Wei, Youzhen; Yang, Nana. Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway. 2022. Frontiers in Pharmacology. 10.3389/fphar.2022.894812