Studies Referencing Hydrogen and Digestive System/Microbiome

Database:

Primary Topic: Gallbladder/Intestine/Pancreas/Stomach

Secondary Topic: Food Poisoning/Gastric Mucosal Injury/Gastric Ulcer/Gastroenteritis/Gastroesophageal Reflux Disease (GERD)/ Indigestion/Inflammatory Bowel Disease (IBD)/Intestinal Injury/Irritable Bowel Syndrome (IBS)/Pancreatitis (or Any)

Tertiary Topic: Constipation/Gut Microbiome/Mycotoxicosis/Necrotizing Enterocolitis/Necrotizing Pancreatitis/Pancreatitis/Postoperative Ileus (or Any)

Stomach Issues

● Hydrogen has been shown to improve stomach issues including

• gastritis (51: Chaves et al 2020),
• Aspirin toxicity (682: Zhang et al 2014; 995: Naito et al 2002; 675: Xue et al 2014),
• stress ulcer (787: Liu et al 2012),
• viral infection (415: Moorman, Montazeri, and Jaykus 2017),
• and gastroesophageal reflux disease (GERD) (282: Franceschelli et al 2018).

Intestinal Issues

● Hydrogen has been shown to improve intestinal issues including

• constipation (1037: Tanaka et al 2021; 236: Tanaka et al 2019; 841: Jahng et al 2011),
• diarrhea (335: Shin et al 2018),
• food poisoning/mycotoxicosis (200: Ji et al 2019; 201: Ji et al 2019; 361: Zheng et al 2018; 362: Zheng et al 2018; 386: Gomez-Espinosa et al 2017),
• inflammatory bowel disease (IBD) (933: Kajiya et al 2009; 426: Shen et al 2017),
• ulcerative colitis (694: Chen et al 2013; 700: He et al 2013; 1052: LeBaron et al 2021; 1128: Song et al 2021; 1133: Ge et al 2022; 1176: Koyama et al 2022),
• irritable bowel syndrome (IBS) (335: Shin et al 2018),
• parasitic worm infestation (938: Lee et al 2009; 957: Kim et al 2008),
• necrotizing enterocolitis (728: Sheng et al 2013; 1122: Yu et al 2021),
• sepsis (294: Ikeda et al 2018; 148: Yin et al 2020; 459: Yu et al 2017; 616: Zhang et al 2015; 1043: Ma et al 2016; 77: Jiang et al 2020; 528: Yang et al 2016; 560: Li et al 2015),
• and ischemia/reperfusion injury (75: Jiang et al 2020; 179: Eryilmaz et al 2019; 252: Yao et al 2019; 442: Wu et al 2017; 826: Chen et al 2011; 949: Zheng et al 2009; 146: Yang et al 2020; 1161: Oral et al 2022).

Pancreatic Issues

● Hydrogen has been shown to improve pancreatic issues including

• pancreatitis (375: Chen et al 2017; 536: Zhou et al 2016; 661: Ren et al 2014; 15: Li et al 2021; 481: Han et al 2016; 751: Zhang, Feng, and Chen 2013; 796: Ren et al 2012; 893: Chen et al 2010; 515: Shi et al 2016)
• and Diabetes-associated inflammation (972: Kim and Kim 2006; 850: Li et al 2011; 851: Li et al 2011; 978: Li et al 2005; 993: Li et al 2002; 963: Kim et al 2007).

Gut Microbiome

● Hydrogen, either exogenous or produced by gut microbes (1061: Christl et al 1992; 1063: Levitt 1969; 1152: Li et al 2019),

• can help to reinvigorate and regulate the gut microbiome (232: Sha et al 2019; 1037: Tanaka et al 2021; 1082: Guo et al 2020; 289: Higashimura et al 2018; 413: Matsumoto et al 2017; 420: Nishimura, Tanabe, and Yamamoto 2017; 133: Zhang et al 2021; 1169: Xie et al 2022),
• resulting in alleviation of morbidities caused by
  • mycotoxicosis (361: Zheng et al 2018),
  • obesity/metabolic syndrome (116: Qiu et al 2020; 259: Zhao et al 2019),
  • ulcerative colitis (1128: Song et al 2021; 1133: Ge et al 2022),
  • Parkinson’s Disease (160: Bordoni et al 2019; 338: Suzuki et al 2018), sepsis (294: Ikeda et al 2018), chemotherapy (19: Lian et al 2021)
  • and radiotherapy (350: Xiao et al 2018) toxicity,
  • Alzheimer’s Disease (1047: Lin et al 2022),
  • decompression sickness (1002: Fahlman 2000),
  • Helicobacter pylori infection (133: Zhang et al 2021),
  • and liver fibrosis (1088: Li et al 2021).

Cancer

● Hydrogen has shown efficacy as a carcinostatic in

• gastric (27: Saitoh et al 2021; 42: Zhu, Cui, and Xu 2021; 51: Chaves et al 2020; 180: Fan et al 2019; 171: Chen et al 2019; 210: Kurokawa et al 2019),
• colorectal (157: Akagi and Baba 2019; 579: Runtuwene et al 2015; 781: Kim, Fischer, and Hung 2012; 1097: Zan et al 2021; 1126: Zan et al 2021; 1168: Zhang et al 2022),
• and gallbladder (169: Chen et al 2019; 170: Chen et al 2019) cancers.

● Hydrogen protects against

• radiotherapy- (350: Xiao et al 2018; 118: Qiu et al 2020)
• and chemotherapy-induced (specifically Gefitinib treatment (237: Terasaki et al 2019))
• gastrointestinal toxicity.

Surgery and Transplantation

● Hydrogen has been shown to effectively prevent and treat morbidities resulting from the transplantation of intestinal (145: Yamamoto et al 2020; 663: Shigeta et al 2014; 823: Buchholz et al 2011; 950: Buchholz et al 2008) and pancreatic tissues (568: Luo et al 2015; 1009: Miyamoto et al 1999).

● Hydrogen protects the intestine from inflammation and morbidity associated with surgery (510: Okamoto et al 2016; 179: Eryilmaz et al 2019; 1097: Zan et al 2021; 1161: Oral et al 2022).

● Hydrogen has been shown to protect the intestine from inflammation and morbidity caused by hemorrhagic (543: Du et al 2015) and burn-induced (774: Jin et al 2012) shock.

● One of the earliest known uses of hydrogen gas is as an intestinal insufflant used in the diagnosis of gastrointestinal pathologies (1026: Pilcher 1888).

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (118: Qiu et al 2020; 663: Shigeta et al 2014; 823: Buchholz et al 2011; 950: Buchholz et al 2008; 568: Luo et al 2015; 543: Du et al 2015; 774: Jin et al 2012; 232: Sha et al 2019; 201: Ji et al 2019; 426: Shen et al 2017; 694: Chen et al 2013; 728: Sheng et al 2013; 294: Ikeda et al 2018; 459: Yu et al 2017; 442: Wu et al 2017; 826: Chen et al 2011; 978: Li et al 2005; 536: Zhou et al 2016; 15: Li et al 2021; 751: Zhang, Feng, and Chen 2013; 796: Ren et al 2012; 893: Chen et al 2010; 682: Zhang et al 2014; 787: Liu et al 2012; 19: Lian et al 2021; 1161: Oral et al 2022),

increasing the activity of endogenous antioxidant enzymes (543: Du et al 2015; 774: Jin et al 2012; 232: Sha et al 2019; 201: Ji et al 2019; 1052: LeBaron et al 2021; 728: Sheng et al 2013; 442: Wu et al 2017; 751: Zhang, Feng, and Chen 2013; 796: Ren et al 2012; 682: Zhang et al 2014; 787: Liu et al 2012; 515: Shi et al 2016; 1128: Song et al 2021),

upregulating cellular protection mechanisms (145: Yamamoto et al 2020; 823: Buchholz et al 2011; 543: Du et al 2015; 201: Ji et al 2019; 426: Shen et al 2017; 148: Yin et al 2020; 459: Yu et al 2017; 1133: Ge et al 2022),

counteracting inflammation and apoptosis (118: Qiu et al 2020; 663: Shigeta et al 2014; 823: Buchholz et al 2011; 950: Buchholz et al 2008; 568: Luo et al 2015; 510: Okamoto et al 2016; 543: Du et al 2015; 774: Jin et al 2012; 232: Sha et al 2019; 200: Ji et al 2019; 201: Ji et al 2019; 933: Kajiya et al 2009; 426: Shen et al 2017; 694: Chen et al 2013; 1052: LeBaron et al 2021; 75: Jiang et al 2020; 160: Bordoni et al 2019; 728: Sheng et al 2013; 294: Ikeda et al 2018; 616: Zhang et al 2015; 77: Jiang et al 2020; 528: Yang et al 2016; 179: Eryilmaz et al 2019; 252: Yao et al 2019; 442: Wu et al 2017; 826: Chen et al 2011; 949: Zheng et al 2009; 146: Yang et al 2020; 661: Ren et al 2014; 15: Li et al 2021; 481: Han et al 2016; 751: Zhang, Feng, and Chen 2013; 796: Ren et al 2012; 893: Chen et al 2010; 682: Zhang et

al 2014; 995: Naito et al 2002; 787: Liu et al 2012; 19: Lian et al 2021; 515: Shi et al 2016; 133: Zhang et al 2021; 1128: Song et al 2021),

improving immune function (157: Akagi and Baba 2019; 938: Lee et al 2009; 957: Kim et al 2008; 375: Chen et al 2017; 1122: Yu et al 2021),

and restoring mitochondrial (118: Qiu et al 2020)

and endoplasmic reticulum (426: Shen et al 2017) function.

Literature Cited (numbered as per database):

● (15) Li, Kun; Yin, Hongling; Duan, Yi; Lai, Peizhen; Cai, Yancheng; Wei, Youzhen. Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression. 2021. BMC Gastroenterology. 10.1186/s12876-021-01640-9

● (19) Lian, Naqi; Shen, Mengxi; Zhang, Kai; Pan, Jiacheng; Jiang, Yi; Yu, Yang; Yu, Yonghao. Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. 2021. Journal of Pain Research. 10.2147/JPR.S288289

● (27) Saitoh, Yasukazu; Kawasaki, Naho; Eguchi, Natsumi; Ikeshima, Minoru. Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4. 2021. Free Radical Research. 10.1080/10715762.2021.1902514

● (42) Zhu, Baocheng; Cui, Hengguan; Xu, Weiqiang. Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis. 2021. Cancer Cell International. 10.1186/s12935-020-01743-5

● (51) Chaves, Juliana R.; de Souza, Carolina R.T.; Modesto, Antonio A.C.; Moreira, Fabiano C.; Teixeira, Eliel B.; Sarraf, Jonathan S.; Allen, Thais S.R.; Araujo, Taissa M.T.; Khayat, Andre S. Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c). 2020. American Journal of Translational Research. 32774757

● (75) Jiang, Shuai; Fan, Qizhong; Xu, Ming; Cheng, Fengchun; Li, Zhihui; Ding, Guojian; Geng, Lei; Fu, Tingliang. Hydrogen-rich saline protects intestinal epithelial tight junction barrier in rats with intestinal ischemia–reperfusion injury by inhibiting endoplasmic reticulum stress induced-apoptosis pathway. 2020. Journal of Pediatric Surgery. 10.1016/j.jpedsurg.2020.01.061

● (77) Jiang, Yi; Bian, Yingxue; Lian, Naqi; Wang, Yaoqi; Xie, Keliang; Qin, Chao; Yu, Yonghao. iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment. 2020. Drug Design, Development and Therapy. 10.2147/DDDT.S271191

● (116) Qiu, Xiangjie; Ye, Qiaona; Sun, Mengxing; Wang, Lili; Tan, Yurong; Wu, Guojun. Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet. 2020. Experimental Biology and Medicine. 10.1177/1535370219898407

● (118) Qiu, Xiaochen; Dong, Kaisheng; Guan, Jingzhi; He, JianMiao. Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and inflammatory response. 2020. International Immunopharmacology. 10.1016/j.intimp.2020.106517

● (133) Zhang, Wei; Zhou, Yanan; Fan, Yating; Cao, Rui; Xu, Yingying; Weng, Zhenzhen; Ye, Jing; He, Cong; Zhu, Yin; Wang, Xiaolei. Metal-Organic Framework Based Hydrogen Release Platform for Multi-Effective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities. 2021. Advanced Materials. 10.1002/adma.202105738

● (145) Yamamoto, Hirotsugu; Aokage, Toshiyuki; Igawa, Takuro; Hirayama, Takahiro; Seya, Mizuki; Ishikawa-Aoyama, Michiko; Nojima, Tsuyoshi; Nakao, Atsunori; Naito, Hiromichi. Luminal preloading with hydrogen-rich saline ameliorates ischemia-reperfusion injury following intestinal transplantation in rats. 2020. Pediatric Transplantation. 10.1111/petr.13848

● (146) Yang, Ling; Guo, Yan; Fan, Xin; Chen, Ye; Yang, Bo; Liu, Ke-Xuan; Zhou, Jun. Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF- κ B/NLRP3 Pathway. 2020. Mediators of Inflammation. 10.1155/2020/4359305

● (148) Yin, Ling; Yang, Man; Yu, Yang; Xie, Keliang; Yu, Yonghao. Hydrogen plays a protective role in intestinal injury of mice with severe sepsis by regulating the release of heme oxygenase-1 and high mobility group protein B1. 2020. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 10.3760/cma.j.cn121430-20200717-00533

● (157) Akagi, Junji; Baba, Hideo. Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. 2019. Oncology Reports. 10.3892/or.2018.6841

● (160) Bordoni, Laura; Gabbianelli, Rosita; Fedeli, Donatella; Fiorini, Dennis; Bergheim, Ina; Jin, Cheng Jun; Marinelli, Lisa; Di Stefano, Antonio; Nasuti, Cinzia. Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease. 2019. PLoS One. 10.1371/journal.pone.0223238

● (169) Chen, Ji-Bing; Mu, Feng; Lu, Tianyu; Ma, Yangyang; Du, Duanming; Xu, Ke-Cheng. A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation. 2019. OncoTargets and Therapy. 10.2147/OTT.S227217

● (170) Chen, Ji-Bing; Pan, Zhong-Bao; Du, Duan-Ming; Qian, Wei; Ma, Yang-Yang; Mu, Feng; Xu, Ke-Cheng. Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. 2019. World Journal of Clinical Cases. 10.12998/wjcc.v7.i15.2065

● (171) Chen, Ji-Bing; Kong, Xiao-Feng; Lv, You-Yong; Qin, Shu-Qun; Sun, Xue-Jun; Mu, Feng; Lu, Tian-Yu; Xu, Ke-Cheng. Real world survey' of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients. 2019. Medical Gas Research. 10.4103/2045-9912.266985

● (179) Eryilmaz, Sibel; Turkyilmaz, Zafer; Karabulut, Ramazan; Gulburun, Merve Altin; Poyraz, Aylar; Gulbahar, Ozlem; Arslan, Burak; Sonmez, Kaan. The effects of hydrogen-rich saline solution on intestinal anastomosis performed after intestinal ischemia reperfusion injury. 2019. Journal of Pediatric Surgery. 10.1016/j.jpedsurg.2019.07.018

● (180) Fan, Mingjian; Wen, Yanyuan; Ye, Dien; Jin, Zhaokui; Zhao, Penghe; Chen, Danyang; Lu, Xifeng; He, Qianjun. Acid‐Responsive H2‐Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy. 2019. Advanced Healthcare Materials. 10.1002/adhm.201900157

● (200) Ji, Xu; Zhang, Qing; Zheng, Weijiang; Yao, Wen. Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in female piglets fed Fusarium mycotoxins contaminated diet. 2019. Journal of Animal Science and Biotechnology. 10.1186/s40104-019-0320-2

● (201) Ji, Xu; Zheng, Weijiang; Yao, Wen. Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial Cells (IPEC-J2) Induced by Deoxynivalenol: A Preliminary Study. 2019. Toxins. 10.3390/toxins12010005

● (210) Kurokawa, Hiromi; Matsui, Hirofumi; Ito, Hiromu; Taninaka, Atsushi; Shigekawa, Hidemi; Dodbiba, Gjergj; Wei, Yuezhou; Fujita, Toyohisa. Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth. 2019. Biomedical Journal of Scientific and Technical Research. 10.26717/BJSTR.2019.19.003361

● (232) Sha, Ji-Bin; Zhang, Shuang-Shuang; Lu, Yi-Ming; Gong, Wen-Jing; Jiang, Xiao-Ping; Wang, Jian-Jun; Qiao, Tong-Ling; Zhang, Hong-Hong; Zhao, Min-Qian; Wang, Da-Peng; Xia, Hua; Li, Zhong-Wei; Chen, Jian-Liang; Zhang, Lin; Zhang, Cheng-Gang. Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China. 2019. Medical Gas Research. 10.4103/2045-9912.248263

● (236) Tanaka, Yoshiharu; Saihara, Yasuhiro; Izumotani, Kyoko; Nakamura, Hajime. Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms. 2019. Medical Gas Research. 10.4103/2045-9912.248267

● (237) Terasaki, Yasuhiro; Suzuki, Tetsuya; Tonaki, Kozue; Terasaki, Mika; Kuwahara, Naomi; Ohsiro, Jumi; Iketani, Masumi; Takahashi, Mayumi; Hamanoue, Makoto; Kajimoto, Yusuke; Hattori, Seisuke; Kawaguchi, Hideo; Shimizu, Akira; Ohsawa, Ikuroh. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. 2019. Laboratory Investigation. 10.1038/s41374-019-0187-z

● (252) Yao, Weifeng; Lin, Xiaoyu; Han, Xue; Zeng, Lanfen; Guo, Anshun; Guan, Yu; Hei, Ziqing; Liu, Jianpei; Huang, Pinjie. MicroRNA Files in the Prevention of Intestinal Ischemia/Reperfusion Injury by Hydrogen Rich Saline. 2019. Bioscience Reports. 10.1042/BSR20191043

● (259) Zhao, Lin; Wang, Yan; Zhang, Guanfei; Zhang, Tiantian; Lou, Jing; Liu, Jiankang. L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet. 2019. Nutrients. 10.3390/nu11123054

● (282) Franceschelli, Sara; Pia Gatta, Daniela Maria; Pesce, Mirko; Ferrone, Alessio; Di Martino, Giuseppe; Di Nicola, Marta; De Lutiis, Maria Anna; Vitacolonna, Ester; Patruno, Antonia; Grilli, Alfredo; Felaco, Mario; Speranza, Lorenza. Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision. 2018. Journal of Cellular and Molecular Medicine. 10.1111/jcmm.13569

● (289) Higashimura, Yasuki; Baba, Yasunori; Inoue, Ryo; Takagi, Tomohisa; Uchiyama, Kazuhiko; Mizushima, Katsura; Hirai, Yasuko; Ushiroda, Chihiro; Tanaka, Yoshinori; Naito, Yuji. Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice. 2018. Medical Gas Research. 10.4103/2045-9912.229597

● (294) Ikeda, Mitsunori; Shimizu, Kentaro; Ogura, Hiroshi; Kurakawa, Takashi; Umemoto, Eiji; Motooka, Daisuke; Nakamura, Shota; Ichimaru, Naotsugu; Takeda, Kiyoshi; Takahara, Shiro; Hirano, Shin-Ichi; Shimazu, Takeshi. Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis. 2018. Shock. 10.1097/SHK.0000000000001098

● (335) Shin, Dong Woo; Yoon, Hyuk; Kim, Hyun Soo; Choi, Yoon Jin; Shin, Cheol Min; Park, Young Soo; Kim, Nayoung; Lee, Dong Ho. Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study. 2018. Evidence-Based Complementary and Alternative Medicine. 10.1155/2018/9147914

● (338) Suzuki, Anzu; Ito, Mikako; Hamaguchi, Tomonori; Mori, Miroshi; Takeda, Yuka; Baba, Ryuko; Watanabe, Takeshi; Kurokawa, Ken; Asakawa, Susuma; Hirayama, Masaaki; Ohno, Kinji. Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease. 2018. PLoS One. 10.1371/journal.pone.0208313

● (350) Xiao, Hui-Wen; Li, Yuan; Luo, Dan; Dong, Jia-Li; Zhou, Li-Xin; Zhao, Shu-Yi; Zheng, Qi-Sheng; Wang, Hai-Chao; Cui, Ming; Fan, Sai-Jun.Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota. 2018. Experimental and Molecular Medicine. 10.1038/emm.2017.246

● (361) Zheng, Weijiang; Ji, Xu; Zhang, Qing; Yao, Wen. Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Fusarium Toxin-Contaminated Diet. 2018. Toxins. 10.3390/toxins10060246

● (362) Zheng, Weijiang; Ji, Xu; Zhang, Qing; Du, Wenchao; Wei, Quanwei; Yao, Wen. Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female Piglets Fed Fusarium Toxins Contaminated Diets. 2018. Toxins. 10.3390/toxins10060228

● (375) Chen, Luguang; Ma, Chao; Bian, Yun; Li, Jing; Wang, Tiegong; Su, Li; Lu, Jianping. Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss. 2017. Cellular Physiology and Biochemistry. 10.1159/000485906

● (386) Gomez-Espinosa, Denise; Cervantes-Aguilar, Francisco Javier; Del Rio-Garcia, Juan Carlos; Villarreal-Barajas, Tania; Vazquez-Duran, Alma; Mendez-Albores, Abraham. Ameliorative Effects of Neutral Electrolyzed Water on Growth Performance, Biochemical Constituents, and Histopathological Changes in Turkey Poults during Aflatoxicosis. 2017. Toxins. 10.3390/toxins9030104

● (413) Matsumoto, Mitsuharu; Fujita, Ayoka; Yamashita, Ayano; Kameoka, Shoichiro; Shimomura, Yumi; Kitada, Yusuke; Tamada, Kazuki; Nakamura, Shigeru; Tsubota, Kazuo. Effects of functional milk containing galactooligosaccharide, maltitol, and glucomannan on the production of hydrogen gas in the human intestine. 2017. Journal of Functional Foods. 10.1016/j.jff.2017.05.013

● (415) Moorman, Eric; Montazeri, Naim; Jaykus, Lee-Ann. Efficacy of Neutral Electrolyzed Water for Inactivation of Human Norovirus. 2017. Applied and Environmental Microbiology. 10.1128/AEM.00653-17

● (420) Nishimura, Naomichi; Tanabe, Hiroki; Yamamoto, Tatsuro Sufficient intake of high amylose cornstarch maintains high colonic hydrogen production for 24 h in rats. 2017. Bioscience, Biotechnology and Biochemistry. 10.1080/09168451.2016.1234929

● (426) Shen, Nai-Ying; Bi, Jian-Bin; Zhang, Jing-Yao; Zhang, Si-Min; Gu, Jing-Xian; Liu, Chang. Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression. 2017. World Journal of Gastroenterology. 10.3748/wjg.v23.i8.1375

● (442) Wu, Mao-Jun; Chen, Min; Sang, Sang; Hou, Long-Long; Tian, Mao-Lang; Li, Kuang; Lv, Fang-Qi. Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to intestinal intussusception in a rat model. 2017. Medical Gas Research. 10.4103/2045-9912.208515

● (459) Yu, Yang; Yang, Yongyan; Bian, Yingxue; Li, Yuan; Liu, Lingling; Zhang, Hongtao; Xie, Keliang; Wang, Guolin; Yu, Yong-Hao. Hydrogen Gas Protects Against Intestinal Injury in Wild Type but Not NRF2 Knockout Mice with Severe Sepsis by Regulating HO-1 and HMGB1 Release. 2017. Shock. 10.1097/SHK.0000000000000856

● (481) Han, Bing; Zhou, Haoxin; Jia, Guang; Wang, Yongwei; Song, Zengfu; Wang, Gang; Pan, Shangha; Bai, Xuewei; Lv, Jianchen; Sun, Bei. MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis. 2016. FEBS Journal. 10.1111/febs.13629

● (510) Okamoto, Ayana; Kohama, Keisuke; Aoyama-Ishikawa, Michiko; Yamashita, Hayato; Fujisaki, Noritomo; Yamada, Taihei; Yumoto, Tetsuya; Nosaka, Nobuyuki; Naito, Hiromichi; Tsukahara, Kohei; Iida, Atsuyoshi; Sato, Keiji; Kotani, Koji; Nakao, Atsunori. Intraperitoneally administered, hydrogen-rich physiologic solution protects against postoperative ileus and is associated with reduced nitric oxide production. 2016. Surgery. 10.1016/j.surg.2016.05.026

● (515) Shi, Qiao; Chen, Chen; Deng, Wen-Hong; Wang, Peng; Zuo, Teng; Zhao, Liang; Yu, Jia; Zhao, Kai-Liang; Mei, Fang-Chao; Li, Chen; Wang, Gui-Rong; Wang, Wei-Xing. Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase–dependent Reactive Oxygen Species. 2016. Pancreas. 10.1097/MPA.0000000000000678

● (528) Yang, Tao; Wang, Lu; Sun, Ruiqiang; Chen, Hongguang; Zhang, Hongtao; Yu, Yang; Wang, Yanyan; Wang, Guolin; Yu, Yonghao; Xie, Ke-Liang. Hydrogen-Rich Medium Ameliorates Lipopolysaccharide-Induced Barrier Dysfunction via Rhoa-Mdia1 Signaling in CACO-2 Cells. 2016. Shock. 10.1097/SHK.0000000000000503

● (536) Zhou, Hao-Xin; Han, Bing; Hou, Li-Min; An, Ting-Ting; Jia, Guang; Cheng, Zhuo-Xin; Ma, Yong; Zhou, Yi-Nan; Rong, Rui; Wang, Shuang-Jia; Wang, Yong-Wei; Sun, Xue-Jun; Pan, Shang-Ha; Sun, Bei. Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis. 2016. PLoS One. 10.1371/journal.pone.0154483

● (543) Du, Zunmin; Liu, Jing; Jia, Haipeng; Xu, Wei; Zhao, Xiao-Min. Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock. 2015. International Journal of Clinical and Experimental Pathology. 26221308

● (560) Li, Yuan; Li, Qi; Chen, Hongguang; Wang, Tao; Liu, Lingling; Wang, Guolin; Xie, Keliang; Yu, Yong-Hao. Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1. 2015. Shock. 10.1097/SHK.0000000000000382

● (568) Luo, Zhu-Lin; Cheng, Long; Ren, Jian-Dong; Fang, Chen; Xiang, Ke; Xu, Hao-Tong; Tang, Li-Jun; Wang, Tao; Tian, Fu-Zhou. Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas Transplantations by Reducing Oxidative Stress in Rats. 2015. Mediators of Inflammation. 10.1155/2015/281985

● (579) Runtuwene, Joshua; Amitani, Haruka; Amitani, Marie; Asakawa, Akihiro; Cheng, Kai-Chun; Inui, Akio. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. 2015. PeerJ. 10.7717/peerj.859

● (616) Zhang, Hongtao; Yu, Yonghao; Ma, Xiaoye; Yang, Tao; Hu, Nan; Wang, Guo-Lin. Effects of hydrogen inhalation on serum pro-inflammatory factors and intestinal injury in mice with severe sepsis. 2015. Chinese Critical Care Medicine. 10.3760/cma.j.issn.2095-4352.2015.06.016

● (661) Ren, Jian-Dong; Ma, Jie; Hou, Jun; Xiao, Wen-Jin; Jin, Wei-Hua; Wu, Juan; Fan, Kai-Hua. Hydrogen-Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice. 2014. Mediators of Inflammation. 10.1155/2014/930894

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