Studies Referencing Hydrogen and Eye - Vision

Database:

Primary Topic: Eye

Secondary Topic: Corneal Injury/Dry Eye/Retinal Injury/Uveal Injury (or Any)

Tertiary Topic: Alkali Burn/Cataract/Corneal Dystrophy/Glaucoma/Optic Nerve Crush (ONC)/Light Damage/Macular Degeneration (or Any)

Eye Injuries

● Hydrogen can help heal and prevent corneal injuries leading to cataract (744: Yang et al 2013; 1036: Li et al 2021),

• and injuries due to alkali burn (45: Arima et al 2020; 50: Cejka et al 2020; 369: Cejka et al 2017; 848: Kubota et al 2011)
• and phacoemulsification surgery (195: Igarashi et al 2019; 487: Igarashi et al 2016; 679: You et al 2014).

● Hydrogen can help heal and prevent retinal injuries leading to glaucoma (604: Yotoka et al 2015),

• macular degeneration (1106: Liang et al 2021),
• and retinitis pigmentosa (434: Tao et al 2017; 449: Yan et al 2017; 470: Chen et al 2016),
• and injuries due to ROS senescence (1152: Li et al 2019),
• diabetic retinopathy (697: Feng et al 2013; 715: Liu et al 2013; 810: Xiao et al 2012),
• excitotoxicity (808: Wei et al 2012),
• hyperoxia (836: Huang et al 2011),
• ischemia-reperfusion (I/R) (348: Wu et al 2018; 524: Wang et al 2016; 564: Liu et al 2015; 910: Oharazawa et al 2010),
• optic nerve crush (664: Sun et al 2014; 678: you et al 2014),
• and retinal vein occlusion (217: Long et al 2019).

● Hydrogen can help heal and prevent uveal injuries due to endotoxemia (351: Yan et al 2018; 448: Yan et al 2017).

Dry Eye

• Hydrogen has been shown to both increase tear production in healthy subjects and those with dry eye (14: Kubota et al 2021).

Light Damage

• Hydrogen has been shown to offer eye protection from exposure to high-intensity white light (578: Qi et al 2015; 735: Tian et al 2013),
• high-intensity blue light (762: Feng et al 2012),
• and ultraviolet (UV) light (370: Cejka et al 2017).

Mode of Action

• Hydrogen shows multiple modes of action, including quenching cellular ROS (50: Cejka et al 2020; 369: Cejka et al 2017; 744: Yang et al 2013; 1036: Li et al 2021; 697: Feng et al 2013; 578: Qi et al 2015; 762: Feng et al 2012; 370: Cejka et al 2017; 604: Yotoka et al 2015; 836: Huang et al 2011; 564: Liu et al 2015; 910: Oharazawa et al 2010; 664: Sun et al 2014; 434: Tao et al 2017; 470: Chen et al 2016),
• increasing the activity of endogenous antioxidant enzymes (45: Arima et al 2020; 50: Cejka et al 2020; 487: Igarashi et al 2016; 744: Yang et al 2013; 697: Feng et al 2013; 578: Qi et al 2015; 434: Tao et al 2017; 470: Chen et al 2016),
• upregulating cellular protection mechanisms (715: Liu et al 2013; 578: Qi et al 2015),
• counteracting inflammation and apoptosis (45: Arima et al 2020; 369: Cejka et al 2017; 848: Kubota et al 2011;1036: Li et al 2021; 715: Liu et al 2013; 810: Xiao et al 2012; 578: Qi et al 2015; 348: Wu et al 2018; 524: Wang et al 2016; 564: Liu et al 2015; 910: Oharazawa et al 2010; 217: Long et al 2019; 434: Tao et al 2017; 1106: Liang et al 2021; 1152: Li et al 2019),
• improving immune function (351: Yan et al 2018; 449: Yan et al 2017),
• and restoring mitochondrial function (604: Yotoka et al 2015).

Literature Cited (numbered as per database):

● (14) Kubota, Miyuki; Kawashima, Motoko; Inoue, Sachiko; Imada, Toshihiro; Nakamura, Shigeru; Kubota, Shunsuke; Watanabe, Mitsuhiro; Takemura, Ryo; Tsubota, Kazuo. Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen. 2021. Nature Scientific Reports. 10.1038/s41598-021-85895-y

● (45) Arima, Takeshi; Igarashi, Tsutomu; Uchiyama, Masaaki; Kobayashi, Maika; Ohsawa, Ikuroh; Shimizu, Akira; Takahashi, Hiroshi. Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model. 2020. International Journal of Ophthalmology. 10.18240/ijo.2020.08.01

● (50) Cejka, Cestmir; Kossl, Jan; Holan, Vladimir; Zhang, John H.; Cejkova, Jitka. An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress. 2020. Oxidative Medicine and Cellular Longevity. 10.1155/2020/7435260

● (195) Igarashi, Tsutomu; Ohsawa, Ikuroh; Kobayashi, Maika; Umemoto, Yusuke; Arima, Takeshi; Suzuki, Hisaharu; Igarashi, Toru; Otsuka, Toshiaki; Takahashi, Hiroshi. Effects of Hydrogen in Prevention of Corneal Endothelial Damage During Phacoemulsification: A Prospective Randomized Clinical Trial. 2019. American Journal of Ophthalmology. 10.1016/j.ajo.2019.04.014

● (217) Long, Pan; Yan, Weiming; He, Mengshan; Zhang, Qianli; Wang, Zhe; Li, Manhong; Xue, Junhui; Chen, Tao; An, Jing; Zhang, Zuo-Ming. Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression. 2019. BMC Ophthalmology. 10.1186/s12886-019-1105-2

● (348) Wu, Jiangchun; Wang, Ruobing; Yang, Danxu; Tang, Wenbin; Chen, Zeli; Sun, Qinglei; Liu, Lin; Zang, Rongyu. Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. 2018. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2017.12.146

● (351) Yan, Wei-Ming; Chen, Tao; Long, Pan; Zhang, Zhe; Liu, Qian; Wang, Xiaocheng; An, Jing; Zhang, Zuo-Ming. Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats. 2018. Medical Science Monitor. 10.12659/MSM.907269

● (369) Cejka, Cestmir; Kossi, Jan; Hermankova, Barbora; Holan, Vladimir; Cejkova, Jitka. Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress. 2017. Oxidative Medicine and Cellular Longevity. 10.1155/2017/8906027

● (370) Cejka, Cestmir; Kossl, Jan; Hermankova, Barbora; Holan, Vladimir; Kubinova, Sarka; Zhang, John H.; Cejkova, Jitka. Retracted: Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage. 2017. Nature Scientific Reports. 10.1038/s41598-017-18334-6

● (434) Tao, Ye; Chen, Tao; Fang, Wei; Yan, Zhongjun; Yang, Qinghua; Huang, Yifei; Yu, Linjun; Fan, Lingling. The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against N-Methyl-N-Nitrosourea Induced Retinal Degeneration: A Topographic Study. 2017. Frontiers in Pharmacology. 10.3389/fphar.2017.00587

● (448) Yan, Wei-Ming; Zhang, Lei; Chen, Tao; Zhao, Guan-Hua; Long, Pan; An, Jing; Zhang, Zuo-Ming. Effects of hydrogen-rich saline on endotoxin-induced uveitis. 2017. Medical Gas Research. 10.4103/2045-9912.202905

● (449) Yan, Wei-Ming; Chen, Tao; Wang, Xiao-Cheng; Qi, Lin-Song; Zhao, Guan-Hua; Yang, Guo-Qing; Ma, Yi-Fei; Tao, Ye; Zhang, Lei; Zhang, Zuo-Ming. The reason for the amelioration of N-methyl-N-nitrosoureainduced retinitis pigmentosa in rats by hydrogen-rich saline. 2017. International Journal of Ophthalmology. 10.18240/ijo.2017.10.03

● (470) Chen, Tao; Tao, Ye; Yan, Weiming; Yang, Guoqing; Chen, Xuemin; Cao, Ruidan; Zhang, Lei; Xue, Junhui; Zhang, Zuo-Ming. Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration. 2016. Experimental Eye Research. 10.1016/j.exer.2016.05.017

● (487) Igarashi, Tsutomu; Ohsawa, Ikuroh; Kobayashi, Maika; Igarashi, Toru; Suzuki, Hisaharu; Iketani, Masumi; Takahashi, Hiroshi. Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery. 2016. Nature Scientific Reports. 10.1038/srep31190

● (524) Wang, Ruobing; Wu, Jiangchun; Chen, Zeli; Xia, Fangzhou; Sun, Qinglei; Liu, Lin. Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury. 2016. Brain Research. 10.1016/j.brainres.2015.12.015

● (564) Liu, Hongwei; Hua, Ning; Xie, Keliang; Zhao, Tingting; Yu, Yong-Hao. Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury. 2015. Molecular Medicine Reports. 10.3892/mmr.2015.3731

● (578) Qi, Lin-Song; Yao, Lu; Liu, Wei; Duan, Wei-Xun; Wang, Bin; Zhang, Lei; Zhang, Zuo-Ming. Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats. 2015. Investigative Ophthalmology and Visual Science. 10.1167/iovs.15-17034

● (604) Yokota, Takashi; Kamimura, Naomi; Igarashi, Tsutomu; Takahashi, Hiroshi; Ohta, Shigeo; Oharazawa, Hideak. Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina: Protective effect of H 2 against retinal damage. 2015. Clinical and Experimental Ophthalmology. 10.1111/ceo.12525

● (664) Sun, Jing-Chuan; Xu, Tao; Zuo, Qiao; Wang, Ruo-Bing; Qi, Ai-Qing; Cao, Wen-Luo; Sun, Ai-Jun; Sun, Xue-Jun; Xu, Jiajun. Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. 2014. PLoS One. 10.1371/journal.pone.0099299

● (678) You, Yu-Xia; Li, J.J.; Li, Y.J.; Ma, Ke. Neuroprotective effects of saturated hydrogen water on retinal ganglion cells in rat optic nerve crush model. 2014. Ophthalmology in China. 10.13281/j.cnki.issn.1004-4469.2014.02.009

● (679) You, Yu-Xia; Liang, Qing-Feng; Li, Yu-Jie; Ma, Ke. The preliminary study on the inhibiting effect of saturated hydrogen water on suture induced corneal neovascularization in rats. 2014. Ophthalmology in China. 10.13281/j.cnki.issn.1004-4469.2014.05.013

● (697) Feng, Yanqing; Wang, Ruobing; Xu, Jiajun; Sun, Jingchuan; Xu, Tao; Gu, Qing; Wu, Xingwei. Hydrogen-Rich Saline Prevents Early Neurovascular Dysfunction Resulting from Inhibition of Oxidative Stress in STZ-Diabetic Rats. 2013. Current Eye Research. 10.3109/02713683.2012.748919

● (715) Liu, Guo-Dan; Zhang, Hong; Wang, Lin; Han, Qing; Zhou, Shi-Feng; Liu, Ping. Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. 2013. International Journal of Ophthalmology. 10.3980/j.issn.2222-3959.2013.03.05

● (735) Tian, Liang; Zhang, Lei; Xia, Feng; An, Jing; Sugita, Yashino Zhang, Zuo-Ming; Hydrogen-rich saline ameliorates the retina against light-induced damage in rats. 2013. Medical Gas Research. 10.1186/2045-9912-3-19

● (744) Yang, Chun-Xiao; Yan, Hong; Ding, Tian-Bing. Hydrogen saline prevents selenite-induced cataract in rats. 2013. Molecular Vision. 23922487

● (762) Feng, Mei; Wang, Xing-Hua; Yang, Xiao-Bo; Xiao, Qing; Jiang, Fa-Gang. Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. 2012. International Journal of Ophthalmology. 10.3980/j.issn.2222-3959.2012.02.07

● (808) Wei, Lihua; Ge, Li; Qin, Shucun; Shi, Yunzhi; Du, Changqing; Du, Hui; Liu, Liwei; Yu, Yang; Sun, Xue-Jun. Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. 2012. Experimental Eye Research. 10.1016/j.exer.2011.11.016

● (810) Xiao, Xiang; Cai, Jiping; Xu, Jiajun; Wang, Ruobing; Cai, Jianmei; Liu, Yun; Xu, Weigang; Sun, Xuejun; Li, Runping. Protective Effects of Hydrogen Saline on Diabetic Retinopathy in a Streptozotocin-Induced Diabetic Rat Model. 2012. Journal of Ocular Pharmacology and Therapeutics. 10.1089/jop.2010.0129

● (836) Huang, Lina; Zhao, Shihong; Zhang, John; Sun, Xue-Jun. Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress and Reduction of VEGF Expression. 2011. Ophthalmic Research. 10.1159/000329600

● (848) Kubota, Miyuka; Shimmura, Shigeto; Kubota, Shunsuke; Miyashita, Hideyuki; Kato, Naoko; Noda, Kousuke; Ozawa, Yoko; Usui, Tomohiko; Ishida, Susumu; Umesawa, Kazuo; Kurihara, Toshihide; Tsubota, Kazuo. Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal Alkali-Burn Model. 2011. Investigative Ophthalmology and Visual Science. 10.1167/iovs.10-6167

● (910) Oharazawa, Hideaki; Igarashi, Tsutomu; Yokota, Takashi; Fujii, Hiroaki; Suzuki, Hisaharu; Machide, Mitsuru; Takahashi, Hiroshi; Ohta, Shigeo; Ohsawa, Ikuroh. Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. 2010. Investigative Ophthalmology and Visual Science. 10.1167/iovs.09-4089

● (1036) Li, Runpu; Qu, Yingxin; Li, Xiaoqi; Tao, Ye; Yang, Qinghua; Wang, Junyi; Diao, Yumei; Li, Qian; Fang, Yifan; Huang, Yifei; Wang, Liqiang. Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway. 2021. Investigative Ophthalmology and Visual Science. 10.1167/iovs.62.9.2

● (1106) Liang, I-Chia; Ko, Wen-Chin; Hsu, Yu-Jou; Lin, Yi-Ru; Chang, Yun-Hsiang; Zong, Hv-Hui; Lai, Pei-Chen; Chang, Der-Chen; Hung, Chi-Feng. The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration. 2021. International Journal of Molecular Sciences. 10.3390/ijms222112049

● (1152) Li, Ruichan; Liu, Yanli; Xie, Jing; Huang, Xudong; Zhang, Li; Liu, Hua; Li, Lihua. Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. 2019. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2019.02.005