Studies Referencing Hydrogen and Skin - Cosmetic

Database:

Primary Topic: Skin

Secondary Topic: Cosmetic Issues/Dermatitis/Erythema/Psoriasis/Shingles/Vitiligo (or Any)

Tertiary Topic: Acne/Keratin Plugs/Dermatophagoides farinae infection/Post-Herpetic Neuralgia/Plastic Surgery/Pressure Ulcer (or Any)

Aging Skin

● Hydrogen has been shown to increase skin density (90: Kwon, Han, and Park 2020) and decrease oxidation (989: Okouchi et al 2003) of aging skin.

Skin Disorders

● Hydrogen has been shown to improve skin blotchiness (158: Asada, Saitoh, and Miwa 2019, 1123: Tanaka, Xiao, and Miwa 2021),

• pemphigus (248: Yang et al 2019),
• keratin plugs (340: Tanaka, Saitoh, and Miwa 2018),
• acne (6: Chilicka, Rogowska, and Szygula 2021; 981: Desai et al 2004),
• dust mite (Dermatophagoides farinae) allergy (702: Ignacio et al 2013),
• dermatitis (395: Kajisa et al 2017; 677: Yoon et al 2014),
• Diabetes-associated skin damage (884: Yu et al 2011),
• Arsenic toxicity (749: Yu et al 2013), Paraben toxicity (926: Yu et al 2010),
• erythematous skin disease (791: Ono et al 2012),
• psoriasis (365: Zhu et al 2018; 554: Ishibashi et al 2015),
• UV-light damage (356: Zhang et al 2018; 703: Ignacio et al 2013; 729: Shin et al 2013; 766: Guo et al 2012; 778: Kato et al 2012; 882: Yoon et al 2011; 1032: Saitoh et al 2021),
• X-Ray radiation damage (671: Watanabe et al 2014),
• shingles (410: Ma et al 2017),
• dermatomyositis (1123: Tanaka, Xiao, and Miwa 2021),
• collagen disease (1123: Tanaka, Xiao, and Miwa 2021),
• and vitiligo (61: Fang et al 2020).

Surgery and Medical Care

● Hydrogen has been shown to reduce tissue injury and promote healing in plastic and cosmetic surgeries (121: Sahin et al 2020; 178: Dong et al 2019; 567: Liu et al 2015; 601: Xiao et al 2015; 752: Zhao et al 2013; 1157: Otani et al 2022; 1163: Li et al 2022).

● Hydrogen has been shown to promote wound healing by increasing collagen expression (120: Safonov et al 2020) and decreasing pathogen load (1007: Yahagi et al 2000; 764: Ge et al 2012),

• including in cases of pressure ulcer (279: Fang et al 2018; 714: Li et al 2013)
• and burn trauma (547: Guo et al 2015; 911: Okajima, Shimokawa, and Ishii 2010; 991: Xin et al 2003; 1004: Nakae and Inaba 2000).

Cancer

● Hydrogen has shown efficacy as a carcinostatic in skin cancer (208: Kou et al 2019; 353: Yang et al 2018; 1025: Dole, Wilson, and Fife 1975; 1078: Zhao et al 2018).

● Hydrogen protects against radiation therapy-induced skin injury (261: Zhou et al 2019; 643: Kunos, Abdallah, and Lyons 2014; 720: Mei et al 2013).

Mode of Action

Hydrogen shows multiple modes of action, including quenching cellular ROS (121: Sahin et al 2020; 261: Zhou et al 2019; 279: Fang et al 2018; 356: Zhang et al 2018; 677: Yoon et al 2014; 884: Yu et al 2011; 926: Yu et al 2010; 703: Ignacio et al 2013; 729: Shin et al 2013; 766: Guo et al 2012; 1032: Saitoh et al 2021; 752: Zhao et al 2013; 547: Guo et al 2015),

• increasing the activity of endogenous antioxidant enzymes (121: Sahin et al 2020; 261: Zhou et al 2019; 279: Fang et al 2018; 677: Yoon et al 2014; 884: Yu et al 2011; 703: Ignacio et al 2013; 766: Guo et al 2012; 547: Guo et al 2015; 1123: Tanaka, Xiao, and Miwa 2021),
• upregulating cellular protection mechanisms (279: Fang et al 2018; 356: Zhang et al 2018; 882: Yoon et al 2011; 410: Ma et al 2017; 567: Liu et al 2015; 61: Fang et al 2020; 547: Guo et al 2015; 1163: Li et al 2022),
• counteracting inflammation and apoptosis (178: Dong et al 2019; 261: Zhou et al 2019; 279: Fang et al 2018; 702: Ignacio et al 2013; 677: Yoon et al 2014; 554: Ishibashi et al 2015; 703: Ignacio et al 2013; 729: Shin et al 2013; 766: Guo et al 2012; 882: Yoon et al 2011; 410: Ma et al 2017; 567: Liu et al 2015; 601: Xiao et al 2015; 752: Zhao et al 2013; 547: Guo et al 2015; 1123: Tanaka, Xiao, and Miwa 2021; 1157: Otani et al 2022; 1163: Li et al 2022),
• improving immune function (395: Kajisa et al 2017),
• and restoring mitochondrial function (749: Yu et al 2013; 61: Fang et al 2020; 714: Li et al 2013).

Literature Cited (numbered as per database):

● (6) Chilicka, Karlona; Rogowska, Aleksandra M.; Szygula, Renata. Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women. 2021. Healthcare. 10.3390/healthcare9020144

● (61) Fang, Wei; Tang, Luyan; Wang, Guizhen; Lin, Jinran; Liao, Wanqing; Pan, Weihua; Xu, Jinhua. Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling. 2020. Journal of Investigative Dermatology. 10.1016/j.jid.2019.03.1165

● (90) Kwon, Hye-Jin; Han, Sang-Beom; Park, Kyung-Won. Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder. 2020. International Journal of Molecular Sciences. 10.3390/ijms21249731

● (120) Safonov, Marina; You, Ying; Lee, Jihyung; Safonov, Vladimir L.; Berman, Diana; Zhu, Donghui. Hydrogen generating patch improves skin cell viability, migration activity, and collagen expression. 2020. Engineered Regeneration. 10.1016/j.engreg.2020.05.001

● (121) Sahin, Ayva; ErganYesilada, Aysin Karasoy; Yalcin, Ozben; Guler, Eray M.; Erbek, Harun; Karabiyik, Damla. Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model. 2020. Journal of Plastic, Reconstructive, and Aesthetic Surgery. 10.1016/j.bjps.2020.12.045

● (158) Asada, Ryoko; Saitoh, Yasukazu; Miwa, Nobuhiko. Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. 2019. Medical Gas Research. 10.4103/2045-9912.260647

● (178) Dong, Xin-Hang; Liu, Hao; Zhang, Ming-Zi; Zhao, Peng-Xiang; Liu, Shu; Hao, Yan; Wang, You-Bin. Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway. 2019. American Journal of Translational Research. 30788005

● (208) Kou, Zhu; Zhao, Penghe; Wang, Zhihao; Jin, Zhaokui; Chen, Lihua; Su, Bao-Lian; He, Qianjun. Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy. 2019. Journal of Materials Chemistry B. 10.1039/C9TB00338J

● (248) Yang, Fanping; Chen, Zihua; Chen, Sheng-An; Zhu, Qinyuan; Wang, Lanting; Zhang, Wenhong; Luo, Xiaoqun. Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow-up for 2 months. 2019. Dermatologic Therapy. 10.1111/dth.13027

● (261) Zhou, Ping; Lin, Bin; Wang, Peng; Pan, Tao; Wang, Shun; Chen, Weisi; Cheng, Shaowen; Liu, Sha. The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats. 2019. Journal of Radiation Research. 10.1093/jrr/rry074

● (279) Fang, Wei; Wang, Ghizhen; Tang, Luyan; Su, Huilin; Chen, Huyan; Liao, Wanqing; Xu, Jinhua. Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer. 2018. Journal of Cellular and Molecular Medicine. 10.1111/jcmm.13704

● (340) Tanaka, Yoshiharu; Saitoh, Yasukazu; Miwa, Nobuhiko. Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. 2018. Medical Gas Research. 10.4103/2045-9912.229598

● (353) Yang, Tian; Jin, Zhaokui; Wang, Zhihao; Zhao, Penghe; Zhao, Bin; Fan, Mingjian; Chen, Lihua; Wang, Tianfu; Su, Bao-Lian; He, Qianjun. Intratumoral high-payload delivery and acid-responsive release of H 2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine. 2018. Applied Materials Today. 10.1016/j.apmt.2018.01.008

● (356) Zhang, Bingxin; Zhao, Zishen; Meng, Xiaoyin; Chen, Hongguang; Fu, Guojun; Xie, Ke-Liang. Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. 2018. International Journal of Molecular Medicine. 10.3892/ijmm.2018.3550

● (365) Zhu, Qinyuan; Wu, Yueshen; Li, Yongmei; Chen, Zihua; Wang, Lanting; Xiong, Hao; Dai, Erhong; Wu, Jianhua; Fan, Bin; Ping, Li; Luo, Xiaoqun. Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. 2018. Nature Scientific Reports. 10.1038/s41598-018-26388-3

● (395) Kajisa, Takuya; Yamaguchi, Takuji; Hu, Ailing; Suetake, Nobuhiro; Kobayashi, Hiroyuki. Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice. 2017. Saudi Medical Journal. 10.15537/smj.2017.9.20807

● (410) Ma, Hongtao; Chen, Hongguang; Dong, Aili; Wang, Yanyan; Bian, Yingxue; Xie, Ke-Liang. Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy. 2017. Chinese Journal of Cellular and Molecular Immunology. 29762002

● (547) Guo, Song-Xue; Jin, Yun Yun; Fang, Quan; You, Chuan Gang; Wang, Xin Gang; Hu, Xin Lei; Han, Chun-Mao. Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats. 2015. PLoS One. 10.1371/journal.pone.0124897

● (554) Ishibashi, Toru; Ichikawa, Miki; Sato, Bunpei; Shibata, Shinji; Hara, Yuichi; Naritomi, Yuji; Okazaki, Ken; Nakashima, Yashuaru; Iwamoto, Yukihide; Koyanagi, Samon; Hara, Hiroshi; Nagao, Tetsuhiko. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. 2015. Molecular Medicine Reports. 10.3892/mmr.2015.3707

● (567) Liu, Yun-Qi; Liu, Yi-Fang; Ma, Xue-Mei; Xiao, Yi-Ding; Wang, You-Bin; Zhang, Ming-Zhi; Cheng, Ai-Xin; Wang, Ting-Ting; Li, Jia-La; Zhao, Peng-Xiang; Xie, Fei; Zhang, Xin. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. 2015. Journal of Plastic, Reconstructive, and Aesthetic Surgery. 10.1016/j.bjps.2015.03.001

● (601) Xiao, Yi-Ding; Liu, Yun-Qi; Zhang, Ming-Zi; Wang, You-Bin; Liu, Yi-Fang; Ma, Xue-Mei. Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury. 2015. Plastic and Aesthetic Research. 10.4103/2347-9264.169499

● (643) Kunos, Charles A.; Abdallah, Rita R.; Lyons, Janice A. Hydration During Breast Radiotherapy May Lower Skin Toxicity. 2014. Breast Journal. 10.1111/tbj.12348

● (671) Watanabe, Sadahiro; Fujita, Masanori; Ishihara, Masayuki; Tachibana, Shoichi; Yamamoto, Yoritsuna; Kaji, Tatsumi; Kawauchi, Toshio; Kanatani, Yasuhiro. Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats. 2014. Journal of Radiation Research. 10.1093/jrr/rru067

● (677) Yoon, Yang-Suk; Sajo, Ma Easter Joy Villarosa; Ignacio, Rosa Mistica Coles; Kim, Soo-Ki; Kim, Ceol-Su; Lee, Kyu-Jae. Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. 2014. Biological and Pharmaceutical Bulletin. 10.1248/bpb.b14-00220

● (702) Ignacio, Rosa Mistica Coles; Kwak, Hyun-Suk; Yun, Young-Uk; Sajo, Ma Eastern Joy V.; Soon, Yang-Suk; Kim, Cheol-Su; Kim, Soo-Ki; Lee, Kyu-Jae. The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. 2013. Evidence-Based Complementary and Alternative Medicine. 10.1155/2013/538673

● (703) Ignacio, Rosa Mistica Coles; Yoon, Yang-Suk; Sajo, Ma Easter Joy; Kim, Cheol-Su; Kim, Dong-Heui; Kim, Soo-Ki; Lee, Kyu-Jae. The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. 2013. Molecular and Cellular Toxicology. 10.1007/s13273-013-0003-6

● (714) Li, Qiang; Kato, Shinya; Matsuoka, Daigo; Tanaka, Hiroshi; Miwa, Nobuhiko. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. 2013. Medical Gas Research. 10.1186/2045-9912-3-20

● (720) Mei, Ke; Zhao, Sanhu; Qian, Liren; Li, Bailong; Ni, Jin; Cai, Jianming. Hydrogen Protects Mice From Dermatitis Caused by Local Radiation. 2013. Journal of Dermatological Treatment. 10.3109/09546634.2012.762639

● (729) Shin, Mi Hee; Park, Raeeun; Nojima, Hideo; Kim, Hyung-Chel; Kim, Yeon Kyung; Chung, Jin Ho. Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. 2013. PLoS One. 10.1371/journal.pone.0061696

● (749) Yu, Wei-Tai; Chiu, Yu-Ching; Lee, Chih-Hung; Yoshioka, Tohru; Yu, Hsin-Su. Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes. 2013. Journal of Asian Earth Sciences. 10.1016/j.jseaes.2013.07.007

● (752) Zhao, Ling; Wang, You-Bin; Qin, Shi-Rui; Ma, Xue-Mei; Sun, Xue-Jun; Wang, Ming-Lian; Zhong, Ru-Gang. Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. 2013. Journal of Zhejiang University - Science B. 10.1631/jzus.B1200317

● (764) Ge, Liangpeng; Zhang, Xiaochun; Cao, Chuan; Gu, Zhaobin; Liu, Zuohua; Liu, Lubin; Lin, Baozhong. Feasibility study of the sterilization of pigskin used as wound dressings by neutral electrolyzed water. 2012. Journal of Trauma and Acute Care Surgery. 10.1097/TA.0b013e318243a1dc

● (766) Guo, Ze; Zhou, Bingrong; Li, Wei; Sun, Xuejun; Luo, Dan. Hydrogen-rich saline protects against ultraviolet B radiation injury in rats. 2012. Journal of Biomedical Research. 10.7555/JBR.26.20110037

● (778) Kato, Shinya; Saito, Yasukazu; Iwai, Keizou; Miwa, Nobuhiko. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. 2012. Journal of Photochemistry and Photobiology. 10.1016/j.jphotobiol.2011.09.006

● (791) Ono, Hirohisa; Nishijima, Yoji; Adachi, Naoto; Sakamoto, Masaki; Kudo, Yohei; Nakazawa, Jun; Kaneko; Kumi; Nakao, Atsunori. Hydrogen (H2) treatment for acute erythymatous skin disease. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. 2012. Medical Gas Research. 10.1186/2045-9912-2-14

● (882) Yoon, Kyung Su; Huang, Xue Zhu; Yoon, Yang Suk; Kim, Soo-Ki; Song, Soon bong; Chang, Byung Soo; Kim, Dong Heui; Lee, Kyu-Jae. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. 2011. Biological and Pharmaceutical Bulletin. 10.1248/bpb.34.1671

● (884) Yu, Pan; Wang, Zhenxiang; Sun, Xuejun; Chen, Xiaohua; Zeng, Suyun; Chen, Liang; Li, Shirong. Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. 2011. Biochemical and Biophysical Research Communications. 10.1016/j.bbrc.2011.05.024

● (911) Okajima, Masahiro; Shimokawa, Ken-Ichi; Ishii, Fumiyoshi. The healing effect of electrolytic-reduction ion water on burn wounds. 2010. Bioscience Trends. 20305342

● (926) Yu, A-Reum; Ryoo, Kun-Kul; Lee, Mi-Young. Suppressive effect of electrolyzed reduced water on the paraben-induced DNA damage in human dermal fibroblast cells. 2010. Journal of the Korea Academia-Industrial Cooperation Society. 10.5762/KAIS.2010.11.11.4427

● (981) Desai, Alpesh; Tam, Cynthia J.; Bhakta, Kinnari; Desai, Tejas; Sarkar, Rashmi; Desai, Neil B. The Efficacy and Tolerability of Electrolyzed Oxidized Water in Treating Mild to Moderate Acne. 2004. Cosmetic Dermatology. https://www.researchgate.net/publication/237566858_The_Efficacy_and_Tolerability_of_Electrolyzed_Oxidized_Water_in_Treating_Mild_to_Moderate_Acne

● (989) Okouchi, Shoichi; Takezaki, Daisuke; Ohnami, Hideyuki; Agishi, Yuhkoh; Kanroji, Yasuo; Ikeda, Shigeo. Electrolyzed-Reduced Water as Artificial Hot Spring Water. 2003. Journal of the Balneological Society of Japan. https://www.researchgate.net/publication/242555470_Electrolyzed-Reduced_Water_as_Artificial_Hot_Spring_Water

● (991) Xin, Hua; Zheng, Ya-Juan; Hajime, Nakae; Han, Zhen-Guo. Effect of electrolyzed oxidizing water and hydrocolloid occlusive dressings on excised burn-wounds in rats. 2003. Chinese Journal of Traumatology. 12857518

● (1004) Nakae, Hajime; Inaba, Hideo. Effectiveness of Electrolyzed Oxidized Water Irrigation in a Burn-Wound Infection Model. 2000. Journal of Trauma. 10.1097/00005373-200009000-00020

● (1007) Yahagi, N.; Kono, M.; Kitahara, M.; Ohmura, A.; Sumita, O.; Hashimoto, T.; Hori, K.; Ning-Juan, C.; Woodson, P.; Kubota, S.; Murakami, A.; Takamoto, S. Effect of electrolyzed water on wound healing. 2000. Artificial Organs. 10.1046/j.1525-1594.2000.06557-3.x

● (1025) Dole, M.; Wilson, F.R.; Fife, W.P. Hyperbaric hydrogen therapy: A possible treatment for cancer. 1975. Science. 10.1126/science.1166304

● (1032) Saitoh, Yasukazu; Yamaguchi, Yuuki; Okada, Yuhei. Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes. 2021. Molecular and Cellular Biochemistry. 10.1007/s11010-021-04189-z

● (1078) Zhao, Penghe; Jin, Zhaokui; Chen, Qian; Yang, Tian; Chen, Danyang; Meng, Jin; Lu, Xifeng; Gu, Zhen; He, Qianjun. Local generation of hydrogen for enhanced photothermal therapy. 2018. Nature Communications. 10.1038/s41467-018-06630-2

● (1123) Tanaka, Yoshiharu; Xiao, Li; Miwa, Nobuhiko. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum. 2021. Medical Gas Research. 10.4103/2045-9912.330692

● (1157) Otani, Naoya; Tomita, Koichi; Kobayashi, Yuki; Kuroda, Kazuya; Koyama, Yoshihisa; Kobayashi, Hikaru; Kubo, Tateki. Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats. 2022. Nature Scientific Reports. 10.1038/s41598-022-10228-6

● (1163) Li, Yujie; Shen, Chengcheng; Zhou, Xin; Zhang, Jianghe; Lai, Xiaoyue; Zhang, Yiming. Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway. 2022. Oxidative Medicine and Cellular Longevity. 10.1155/2022/2949824