Studies Referencing Hydrogen and Ear - Hearing

Database:

Primary Topic: Ear

Secondary Topic: Hearing Loss (or Any)

Tertiary Topic: Auditory Neuropathy (AN)/Noise Pollution (or Any)

Hydrogen can help prevent ototoxicity and hearing loss due to

• radiotherapy (1173: Kong et al 2022),
• chemotherapy (specifically Cisplatin (380: Fransson et al 2017; 641: Kikkawa et al 2014; 868: Qu et al 2011)),
• carbon monoxide (CO) exposure (265: Bagheri et al 2018),
• Auditory Neuropathy (AN) (795: Qu et al 2012),
• ischemia-reperfusion injury (421: Ogawa et al 2017),
• oxidative stress (935: Kikkawa et al 2009; 919: Taura et al 2010),
• and noise pollution (265: Bagheri et al 2018; 228: Pirttila et al 2019; 374: Chen et al 2017; 623: Chen et al 2014; 644: Kurioka et al 2014; 820: Zhou et al 2012; 852: Lin et al 2011; 856: Lu et al 2011; 1039: Fransson et al 2021).

Mode of Action

Hydrogen shows multiple modes of action, including

• quenching cellular ROS (641: Kikkawa et al 2014; 868: Qu et al 2011; 623: Chen et al 2014; 644: Kurioka et al 2014; 935: Kikkawa et al 2009; 919: Taura et al 2010),
• upregulating cellular protection mechanisms (374: Chen et al 2017),
• and counteracting inflammation and apoptosis (374: Chen et al 2017).

Literature Cited (numbered as per database):

● (228) Pirttila, Kristian; Pierre, Pernilla Videhult; Haglof, Jakob; Engskog, Mikael; Hedeland, Mikael; Laurell, Goran; Arvidsson, Torbjorn; Pettersson, Curt. An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs. 2019. Metabolomics. 10.1007/s11306-019-1595-1

● (265) Bagheri, Fereshte; Pourbakht, Akram; Raisi, Ahmadreza; Kamali, Mohammad; Faridan, Mohammad. The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs. 2018. Health Scope. 10.5812/jhealthscope.55353

● (374) Chen, Liwei; Han, Mingkun; Lu, Yan; Chen, Daishi; Sun, Xuejun; Yang, Shiming; Sun, Wei; Yu, Ning; Zhai, Suoqiang. Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss. 2017. Acta Oto-Laryngologica. 10.1080/00016489.2017.1328743

● (380) Fransson, Anette E.; Kisiel, Marta; Pirttila, Kristian; Pettersson, Curt; Pierre, Pernilla Videhult; Laurell, Goran F.E. Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig. 2017. Frontiers in Cellular Neuroscience. 10.3389/fncel.2017.00280

● (421) Ogawa, Hideo; Okada, Masahiro; Shudou, Masachika; Gyo, Kiyofumi; Hato, Naohito. Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil. 2017. Neuroscience Letters. 10.1016/j.neulet.2017.12.013

● (623) Chen, Liwei; Yu, Ning; Lu, Yan; Wu, Longjun; Chen, Daishi; Guo, Weiwei; Zhao, Lidong; Liu, Mingbo; Yang, Shiming; Sun, Xuejun; Zhai, Suoqiang. Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect. 2014. PLoS One. 10.1371/journal.pone.0100774

● (641) Kikkawa, Yayoi S.; Nakagawa, Takayuki; Taniguchi, Mirei; Ito, Juichi. Hydrogen protects auditory hair cells from cisplatin-induced free radicals. 2014. Neuroscience Letters. 10.1016/j.neulet.2014.07.025

● (644) Kurioka, Takaomi; Matsunobu, Takeshi; Satoh, Yasushi; Niwa, Katsuki; Shiotani, Akihiro. Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. 2014. Neuroscience Research. 10.1016/j.neures.2014.08.009

● (795) Qu, Juan; Gan, Yun-Na; Xie, Ke-Liang; Liu, Wen-Bo; Wang, Ya-Fei; Hei, Ren-Yi; Mi, Wen-Juan; Qiu, Jian-Hua. Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. 2012. Acta Pharmacologica Sinica. 10.1038/aps.2011.190

● (820) Zhou, Y.; Zheng, H.; Ruan, F.; Chen, X.; Zheng, G.; Kang, M.; Zhang, Q.; Sun, Xue-Jun. Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. 2012. Neuroscience. 10.1016/j.neuroscience.2012.02.028

● (852) Lin, Ying; Kashio, Akinori; Sakamoto, Takashi; Suzukawa, Keigo; Kakigi, Akinobu; Yamasoba, Tatsuya. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. 2011. Neuroscience Letters. 10.1016/j.neulet.2010.09.064

● (856) Lu, Yan; Yu, Ning; Li, Xing-Qi; Sun, Xue-Jun; Wang, Qiu-Ju; Yang, Shi-Ming; Zhai, Suo-Qiang. Saturated hydrogen saline protects against noise–induced hearing loss. 2011. Journal of Otology. 10.1016/S1672-2930(11)50006-6

● (868) Qu, Juan; Li, Xu; Wang, Juan; Mi, Wenjuan; Xie, Keliang; Qiu, Jian-Hua. Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. 2011. International Journal of Pediatric Otorhinolaryngology. 10.1016/j.ijporl.2011.10.014

● (919) Taura, Akiko; Kikkawa, Yayoi; Nakagawa, Takayuki; Ito, Juichi. Hydrogen protects vestibular hair cells from free radicals. 2010. Acta Oto-Laryngologica. 10.3109/00016489.2010.486799

● (935) Kikkawa, Yayoi S.; Nakagawa, Takayuki; Horie, Rie T.; Ito, Juichi. Hydrogen protects auditory hair cells from free radicals. 2009. Neuroreport. 10.1097/WNR.0b013e32832a5c68

● (1039) Fransson, Anette Elisabeth; Pierre, Pernilla Videhult; Risling, Marten; Laurell, Goran Frans Emanuel. Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss. 2021. Frontiers in Cellular Neuroscience. 10.3389/fncel.2021.658662

● (1173) Kong, Xiaofeng; Lu, Tianyu; Lu, You-Yong; Yin, Zhinan; Xu, Kecheng. Effect of Hydrogen Inhalation Therapy on Hearing Loss of Patients With Nasopharyngeal Carcinoma After Radiotherapy. 2022. Frontiers in Medicine. 10.3389/fmed.2022.828370